Regulation of blood oxygen transport in hibernating mammals

TY - JOUR

T1 - Regulation of blood oxygen transport in hibernating mammals

AU - Revsbech, Inge G.

AU - Fago, Angela

PY - 2017/7

Y1 - 2017/7

N2 - Along with the periodic reductions in O-2 requirements of mammalian hibernators during winter, the O-2 affinity of the blood of mammalian hibernators is seasonally regulated to help match O-2 supply to consumption, contributing to limit tissue oxidative stress, particularly at arousals. Specifically, mammalian hibernators consistently show an overall increase in the blood-O-2 affinity, which causes a decreased O-2 unloading to tissues, while having similar or lower tissue O-2 tensions during hibernation. This overview explores how the decreased body temperature and concentration of red blood cell 2,3-diphosphoglycerate (DPG) that occur in hibernation contribute separately or in combination to the concurrent increase in the O-2 affinity of the hemoglobin, the O-2 carrier protein of the blood. Most mammalian hemoglobins are responsive to changes in DPG concentrations, including that of the hibernating brown bear, although the smaller hibernators, such as golden-mantled ground squirrel, chipmunks, and dormice, have hemoglobins with low sensitivity to DPG. While the effect of DPG on oxygenation may vary, the decrease in body temperature invariably increases hemoglobin's O-2 affinity in all hibernating species. However, the temperature sensitivity of hemoglobin oxygenation is low in hibernators compared to human, apparently due in part to endothermic allosteric quaternary transition in ground squirrels and dissociation of chloride ions in brown bears. A low heat of blood oxygenation in temporal heterotherms, like hibernators, may thus contribute to reduce heat loss, as found in regional heterotherms, like polar mammals, although the significance would be low in winter hibernation.

AB - Along with the periodic reductions in O-2 requirements of mammalian hibernators during winter, the O-2 affinity of the blood of mammalian hibernators is seasonally regulated to help match O-2 supply to consumption, contributing to limit tissue oxidative stress, particularly at arousals. Specifically, mammalian hibernators consistently show an overall increase in the blood-O-2 affinity, which causes a decreased O-2 unloading to tissues, while having similar or lower tissue O-2 tensions during hibernation. This overview explores how the decreased body temperature and concentration of red blood cell 2,3-diphosphoglycerate (DPG) that occur in hibernation contribute separately or in combination to the concurrent increase in the O-2 affinity of the hemoglobin, the O-2 carrier protein of the blood. Most mammalian hemoglobins are responsive to changes in DPG concentrations, including that of the hibernating brown bear, although the smaller hibernators, such as golden-mantled ground squirrel, chipmunks, and dormice, have hemoglobins with low sensitivity to DPG. While the effect of DPG on oxygenation may vary, the decrease in body temperature invariably increases hemoglobin's O-2 affinity in all hibernating species. However, the temperature sensitivity of hemoglobin oxygenation is low in hibernators compared to human, apparently due in part to endothermic allosteric quaternary transition in ground squirrels and dissociation of chloride ions in brown bears. A low heat of blood oxygenation in temporal heterotherms, like hibernators, may thus contribute to reduce heat loss, as found in regional heterotherms, like polar mammals, although the significance would be low in winter hibernation.

KW - 2,3-Diphosphoglycerate

KW - Allosteric effects

KW - Enthalpy of oxygenation

KW - Metabolic depression

KW - Hemoglobin-oxygen affinity

KW - Hibernation

KW - BEAR URSUS-ARCTOS

KW - LOWLAND DEER MICE

KW - GROUND-SQUIRRELS

KW - ORGANIC-PHOSPHATES

KW - HEMOGLOBIN-FUNCTION

KW - BODY-TEMPERATURE

KW - BROWN BEARS

KW - RESPIRATORY PROPERTIES

KW - METABOLIC SUPPRESSION

KW - ALLOSTERIC REGULATION

U2 - 10.1007/s00360-017-1085-6

DO - 10.1007/s00360-017-1085-6

M3 - Journal article

C2 - 28324160

SN - 0174-1578

VL - 187

SP - 847

EP - 856

JO - Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology

JF - Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology

IS - 5-6

T2 - 15th International Hibernation Symposium

Y2 - 31 July 2016 through 4 August 2016

ER -