Region-Specific Effects of Trigeminal Capsaicin Stimulation

Catharina Egholm Poulsen; Karina Haugaard Bendixen; Astrid Juhl Terkelsen; Arne May; John Hansen; Peter Svensson

doi:10.11607/ofph.2303

Region-Specific Effects of Trigeminal Capsaicin Stimulation

Catharina Egholm Poulsen, Karina Haugaard Bendixen, Astrid Juhl Terkelsen, Arne May, John Hansen, Peter Svensson

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

10 Citations (Scopus)

Abstract

AIMS: To investigate the region-specific effects of painful trigeminal capsaicin stimulation in healthy participants.

METHODS: Twenty healthy participants (10 men and 10 women) participated in four sessions in which they received application of 0.05 mL Vaseline (placebo) or capsaicin cream (0.1%) to a different area innervated by the three branches of the trigeminal nerve: the supraorbital area (V1), the nasal mucosa (V1/V2), and the maxillary (V2) and mandibular (V3) oral mucosa. The participants rated their perceived sensations on a 0-50-100 numeric rating scale (NRS). Thermal (5°C, 23°C, and 50°C) and mechanical (32 mN and 256 mN) sensitivities were assessed. The Schirmer tearing test was used to monitor the lacrimation level as a local measure of autonomic activity, and the Task Force Monitor was used to record systemic autonomic activity. Data were analyzed using repeated measures analysis of variance.

RESULTS: Capsaicin application evoked significantly higher overall NRS scores (P < .001) and induced significantly higher ratings to the heat stimuli (P < .009) in all sessions compared to control. For lacrimation level, capsaicin stimulation resulted in a significant increase compared to control (P < .0002) only in the nasal mucosa session.

CONCLUSION: Topical application of capsaicin cream to the different branches of the trigeminal nerve caused higher NRS scores along with an altered somatosensory sensitivity. Furthermore, in the nasal mucosa session, a robust local and generalized parasympathetic activation appeared following capsaicin application.

Original language	English
Journal	Journal of Oral & Facial Pain and Headache
Volume	33
Issue	3
Pages (from-to)	318–330
Number of pages	13
ISSN	1064-6655
DOIs	https://doi.org/10.11607/ofph.2303
Publication status	Published - 2019

Keywords

CLUSTER HEADACHE
EXPERIMENTAL PAIN MODEL
HEART-RATE-VARIABILITY
INTRADERMAL INJECTION
MENTHOL
OROFACIAL PAIN
SCHIRMER TEST
SENSITIZATION
SOMATOSENSORY SENSITIVITY
TRIGEMINOCARDIAC REFLEX
autonomic nervous system
capsaicin
experimental pain model
trigeminal nociception
trigeminal parasympathetic reflex

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10.11607/ofph.2303

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@article{530e70a3ad0e40cabcb6a2f545b1b801,

title = "Region-Specific Effects of Trigeminal Capsaicin Stimulation",

abstract = "AIMS: To investigate the region-specific effects of painful trigeminal capsaicin stimulation in healthy participants.METHODS: Twenty healthy participants (10 men and 10 women) participated in four sessions in which they received application of 0.05 mL Vaseline (placebo) or capsaicin cream (0.1%) to a different area innervated by the three branches of the trigeminal nerve: the supraorbital area (V1), the nasal mucosa (V1/V2), and the maxillary (V2) and mandibular (V3) oral mucosa. The participants rated their perceived sensations on a 0-50-100 numeric rating scale (NRS). Thermal (5°C, 23°C, and 50°C) and mechanical (32 mN and 256 mN) sensitivities were assessed. The Schirmer tearing test was used to monitor the lacrimation level as a local measure of autonomic activity, and the Task Force Monitor was used to record systemic autonomic activity. Data were analyzed using repeated measures analysis of variance.RESULTS: Capsaicin application evoked significantly higher overall NRS scores (P < .001) and induced significantly higher ratings to the heat stimuli (P < .009) in all sessions compared to control. For lacrimation level, capsaicin stimulation resulted in a significant increase compared to control (P < .0002) only in the nasal mucosa session.CONCLUSION: Topical application of capsaicin cream to the different branches of the trigeminal nerve caused higher NRS scores along with an altered somatosensory sensitivity. Furthermore, in the nasal mucosa session, a robust local and generalized parasympathetic activation appeared following capsaicin application.",

keywords = "CLUSTER HEADACHE, EXPERIMENTAL PAIN MODEL, HEART-RATE-VARIABILITY, INTRADERMAL INJECTION, MENTHOL, OROFACIAL PAIN, SCHIRMER TEST, SENSITIZATION, SOMATOSENSORY SENSITIVITY, TRIGEMINOCARDIAC REFLEX, autonomic nervous system, capsaicin, experimental pain model, trigeminal nociception, trigeminal parasympathetic reflex",

author = "Poulsen, {Catharina Egholm} and Bendixen, {Karina Haugaard} and Terkelsen, {Astrid Juhl} and Arne May and John Hansen and Peter Svensson",

year = "2019",

doi = "10.11607/ofph.2303",

language = "English",

volume = "33",

pages = "318–330",

journal = "Journal of Oral & Facial Pain and Headache",

issn = "1064-6655",

publisher = "Quintessence Publishing Company",

number = "3",

}

Region-Specific Effects of Trigeminal Capsaicin Stimulation. / Poulsen, Catharina Egholm; Bendixen, Karina Haugaard ; Terkelsen, Astrid Juhl et al.
In: Journal of Oral & Facial Pain and Headache, Vol. 33, No. 3, 2019, p. 318–330.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Region-Specific Effects of Trigeminal Capsaicin Stimulation

AU - Poulsen, Catharina Egholm

AU - Bendixen, Karina Haugaard

AU - Terkelsen, Astrid Juhl

AU - May, Arne

AU - Hansen, John

AU - Svensson, Peter

PY - 2019

Y1 - 2019

N2 - AIMS: To investigate the region-specific effects of painful trigeminal capsaicin stimulation in healthy participants.METHODS: Twenty healthy participants (10 men and 10 women) participated in four sessions in which they received application of 0.05 mL Vaseline (placebo) or capsaicin cream (0.1%) to a different area innervated by the three branches of the trigeminal nerve: the supraorbital area (V1), the nasal mucosa (V1/V2), and the maxillary (V2) and mandibular (V3) oral mucosa. The participants rated their perceived sensations on a 0-50-100 numeric rating scale (NRS). Thermal (5°C, 23°C, and 50°C) and mechanical (32 mN and 256 mN) sensitivities were assessed. The Schirmer tearing test was used to monitor the lacrimation level as a local measure of autonomic activity, and the Task Force Monitor was used to record systemic autonomic activity. Data were analyzed using repeated measures analysis of variance.RESULTS: Capsaicin application evoked significantly higher overall NRS scores (P < .001) and induced significantly higher ratings to the heat stimuli (P < .009) in all sessions compared to control. For lacrimation level, capsaicin stimulation resulted in a significant increase compared to control (P < .0002) only in the nasal mucosa session.CONCLUSION: Topical application of capsaicin cream to the different branches of the trigeminal nerve caused higher NRS scores along with an altered somatosensory sensitivity. Furthermore, in the nasal mucosa session, a robust local and generalized parasympathetic activation appeared following capsaicin application.

AB - AIMS: To investigate the region-specific effects of painful trigeminal capsaicin stimulation in healthy participants.METHODS: Twenty healthy participants (10 men and 10 women) participated in four sessions in which they received application of 0.05 mL Vaseline (placebo) or capsaicin cream (0.1%) to a different area innervated by the three branches of the trigeminal nerve: the supraorbital area (V1), the nasal mucosa (V1/V2), and the maxillary (V2) and mandibular (V3) oral mucosa. The participants rated their perceived sensations on a 0-50-100 numeric rating scale (NRS). Thermal (5°C, 23°C, and 50°C) and mechanical (32 mN and 256 mN) sensitivities were assessed. The Schirmer tearing test was used to monitor the lacrimation level as a local measure of autonomic activity, and the Task Force Monitor was used to record systemic autonomic activity. Data were analyzed using repeated measures analysis of variance.RESULTS: Capsaicin application evoked significantly higher overall NRS scores (P < .001) and induced significantly higher ratings to the heat stimuli (P < .009) in all sessions compared to control. For lacrimation level, capsaicin stimulation resulted in a significant increase compared to control (P < .0002) only in the nasal mucosa session.CONCLUSION: Topical application of capsaicin cream to the different branches of the trigeminal nerve caused higher NRS scores along with an altered somatosensory sensitivity. Furthermore, in the nasal mucosa session, a robust local and generalized parasympathetic activation appeared following capsaicin application.

KW - CLUSTER HEADACHE

KW - EXPERIMENTAL PAIN MODEL

KW - HEART-RATE-VARIABILITY

KW - INTRADERMAL INJECTION

KW - MENTHOL

KW - OROFACIAL PAIN

KW - SCHIRMER TEST

KW - SENSITIZATION

KW - SOMATOSENSORY SENSITIVITY

KW - TRIGEMINOCARDIAC REFLEX

KW - autonomic nervous system

KW - capsaicin

KW - experimental pain model

KW - trigeminal nociception

KW - trigeminal parasympathetic reflex

UR - http://www.scopus.com/inward/record.url?scp=85070184838&partnerID=8YFLogxK

U2 - 10.11607/ofph.2303

DO - 10.11607/ofph.2303

M3 - Journal article

C2 - 30978271

SN - 1064-6655

VL - 33

SP - 318

EP - 330

JO - Journal of Oral & Facial Pain and Headache

JF - Journal of Oral & Facial Pain and Headache

IS - 3

ER -

Region-Specific Effects of Trigeminal Capsaicin Stimulation

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Keywords

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