Reference Cap of Poly Vinyl Alcohol for Quantitative Elastography of the Human Uterine Cervix

Anne Katrine Leonhard, Puk Sandager, Christina Kjærgaard Rasmussen, Lene Hee, Niels Uldbjerg

Research output: Contribution to conferencePosterResearchpeer-review

Abstract

CONTROL ID: 2522419
ABSTRACT FINAL ID: EP22.04
TITLE: Reference Cap of Poly Vinyl Alcohol for Quantitative Elastography of the Human Uterine Cervix
AUTHORS (FIRST NAME, LAST NAME): Anne Katrine Leonhard1, Puk Sandager1, Christina K. Rasmussen1, Hee Lene1, Niels Uldbjerg1
INSTITUTIONS (ALL): 1. Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus N, Denmark.
ABSTRACT BODY:
Objectives: To develop a reference cap for the ultrasound probe that allows for quantitative elastography of the cervical uterine tissue with preservation of a good ultrasonic image. Further to perform inter-intra observer evaluations.

Methods: Two types of reference caps were developed. Cap 1 made of Poly Vinyl Alcohol [PVA] with the Young’s modulus [E] of 0.09 N/mm2. Cap 2 made of silicone and oil with the Young’s modulus of 0.4 N/mm2. Elastography was conducted with the caps applied to a 2D transvaginal ultrasound transducer on seven non-pregnant and six full-term pregnant women. Strain ratio between selected Region of Interest was calculated by the software. The approximated E of the anterior cervical lip was calculated by multiplying strain ratio by the E of the reference cap. To assess the inter-intra observer variability, two observers performed elastography on four phantoms with different E using both reference caps.

Results: Reference Cap 1 had an improved fit for the ultrasound probe and imaging of optimal quality compared to reference Cap 2. The results obtained with the two different caps were consistent. The approximated E of the cervical tissue in non-pregnant women was 0.25 N/mm2 (0.09-0.72) using Cap 1 vs. 0.18 (0.8-0.38) using Cap 2, p= 0.74 (Wilcoxon signed-rank test). The approximated E in the full-term pregnant women was 0.02 (0.01-0.04) using Cap 1 vs 0.02 (0.01-0.03) using Cap 2, p= 0.45 (Wilcoxon signed-rank test). The stiffness of the tissue was significantly different between non-pregnant and full-term pregnant women, p= 0.003 (Wilcoxon rank-sum test). Inter-observer and intra-observer limits-of-agreements were 55% and 23% respectively.

Conclusions: The reference cap of PVA constitutes a promising tool for quantitative elastography of the anterior cervical lip, with an ultrasonic image of good quality and ability to significantly distinguish between cervical mechanical properties.
Original languageEnglish
Publication date6 Sept 2016
Publication statusPublished - 6 Sept 2016
Event26th World Congress on Ultrasound in Obstetrics and Gynecology - Rome, Italy
Duration: 25 Sept 201628 Sept 2016
http://www.isuog.org/WorldCongress/2016

Conference

Conference26th World Congress on Ultrasound in Obstetrics and Gynecology
Country/TerritoryItaly
CityRome
Period25/09/201628/09/2016
Internet address

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