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Reevaluation of the Reactivity of Superoxide Radicals with a Sulfonamide Antibiotic, Sulfacetamide: An Experimental and Theoretical Study

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  • Zonghao Luo, Central South University
  • ,
  • Richard Spinney, Ohio State Univ, Ohio State University, Dept Chem & Biochem
  • ,
  • Zongsu Wei
  • Wei-Ping Hu, Natl Chung Cheng Univ, National Chung Cheng University, Dept Chem & Biochem
  • ,
  • Frederick A. Villamena, Ohio State Univ, Ohio State University, Davis Heart & Lung Res Inst
  • ,
  • Weihua Song, Fudan Univ, Fudan University, Dept Environm Sci & Engn
  • ,
  • Dionysios D. Dionysiou, Univ Cincinnati, University of Cincinnati, Dept Chem & Environm Engn ChEE, Environm Engn & Sci Program
  • ,
  • Ruiyang Xiao, Central South University

Superoxide radical (O-2(center dot-)) is a ubiquitous reactive oxygen species in sunlit natural waters. Here, we selected sulfacetamide (SCT) as a representative sulfonamide antibiotic to investigate its reactivity with O-2(center dot-), as this reaction was reported to be fast with the rate constant k of 7.0 x 10(7) M-1 s(-1). The degradation kinetics of SCT were first studied in the classic McDowell systems (i.e., ultraviolet, acetone, and alcohols) for optimal O-2(center dot-) productivity. Comparison of the apparent first-order degradation rates (k(app)) revealed that 70 mM acetone and 1 M isopropanol were optimal for k(app), but it was only similar to 10% faster than the control. The small degree of enhancement of k(app) led us to suspect its high reported reactivity with O-2(center dot-). Therefore, we reevaluated this reaction in organic and aqueous solutions by a suite of spectroscopic techniques, and all evidence indicated that the measured k values were 6 orders of magnitude smaller than the reported one. The low reactivity was also confirmed by theoretical calculations at the M06-2X level of theory. Our results are of practical and scientific importance for the holistic assessment of the role of O-2(center dot-) in remediation and attenuation of organic contaminants in natural and engineered waters.

Original languageEnglish
JournalACS EST Water
Volume1
Issue11
Pages (from-to)2339-2347
Number of pages9
DOIs
Publication statusPublished - Nov 2021

    Research areas

  • superoxide radicals, sulfonamide antibiotic, reactivity, in situ long-path spectroscopic technique, DFT, NITRO BLUE TETRAZOLIUM, CARBON-TETRACHLORIDE, HYDROGEN-PEROXIDE, PHOTOCHEMICAL GENERATION, RATE CONSTANTS, DEGRADATION, OXYGEN, REDUCTION, OXIDATION, KINETICS

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