Reduced 3-year risk of hospital admission and mortality after 12-week resistance training of cirrhosis patients: A follow-up of a randomized clinical trial

Luise Aamann; Gitte Dam; Peter Jepsen; Mette Borre; Aska Drljevic-Nielsen; Kristian Overgaard; Henning Andersen; Hendrik Vilstrup; Niels Kristian Aagaard

doi:10.1111/jgh.16141

Reduced 3-year risk of hospital admission and mortality after 12-week resistance training of cirrhosis patients: A follow-up of a randomized clinical trial

Luise Aamann^*, Gitte Dam, Peter Jepsen, Mette Borre, Aska Drljevic-Nielsen, Kristian Overgaard, Henning Andersen, Hendrik Vilstrup, Niels Kristian Aagaard

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Abstract

Background and Aim: Physical activity confers health benefits in many diseases but remains almost unstudied for cirrhosis. We investigated whether a period of resistance training affects the subsequent long-term risk of hospitalization or mortality among patients with cirrhosis. Methods: The study includes 39 participants with cirrhosis Child–Pugh class A/B who participated in a prior clinical trial randomized to either resistance training three times per week for 12 weeks or a control group. We gathered data through medical records from trial entry and the following 3 years. The outcomes were time to first hospitalization and all-cause mortality. We used regression models to examine the associations between trial groups and outcomes, adjusting for Child–Pugh class, age, gender, and comorbidity. Results: Nine patients who trained and 15 controls were hospitalized, resulting in a lower risk of first hospitalization in the training group (adjusted subdistribution hazard ratio of 0.40, 95% confidence interval [CI] [0.17, 0.92]; P = 0.03). One patient who trained and six controls died, resulting in a lower all-cause mortality in the training group (adjusted hazard ratio of 0.06, 95% CI [0.01, 0.66]; P = 0.02). Conclusion: Twelve weeks of resistance training was associated with a reduced risk of first hospitalization and mortality among patients with cirrhosis Child–Pugh class A/B 3 years after trial entry. The mechanisms of this effect are not identified, and larger studies are warranted.

Original language	English
Journal	Journal of Gastroenterology and Hepatology
Volume	38
Issue	8
Pages (from-to)	1365-1371
Number of pages	7
ISSN	0815-9319
DOIs	https://doi.org/10.1111/jgh.16141
Publication status	Published - Aug 2023

Keywords

Chronic liver disease
Cirrhosis
Exercise
Morbidity
Physical activity
Sarcopenia
Survival
Training
Liver Cirrhosis/complications
Follow-Up Studies
Humans
Hospitalization
Resistance Training
Hospitals
Fibrosis

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J of Gastro and Hepatol - 2023 - Aamann - Reduced 3‐year risk of hospital admission and mortality after 12‐week resistanceFinal published version, 271 KBLicence: CC BY-NC-ND

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Aamann, L., Dam, G., Jepsen, P., Borre, M., Drljevic-Nielsen, A., Overgaard, K., Andersen, H., Vilstrup, H., & Aagaard, N. K. (2023). Reduced 3-year risk of hospital admission and mortality after 12-week resistance training of cirrhosis patients: A follow-up of a randomized clinical trial. Journal of Gastroenterology and Hepatology, 38(8), 1365-1371. https://doi.org/10.1111/jgh.16141

@article{a07e9f9757e540678d747b763a186532,

title = "Reduced 3-year risk of hospital admission and mortality after 12-week resistance training of cirrhosis patients: A follow-up of a randomized clinical trial",

abstract = "Background and Aim: Physical activity confers health benefits in many diseases but remains almost unstudied for cirrhosis. We investigated whether a period of resistance training affects the subsequent long-term risk of hospitalization or mortality among patients with cirrhosis. Methods: The study includes 39 participants with cirrhosis Child–Pugh class A/B who participated in a prior clinical trial randomized to either resistance training three times per week for 12 weeks or a control group. We gathered data through medical records from trial entry and the following 3 years. The outcomes were time to first hospitalization and all-cause mortality. We used regression models to examine the associations between trial groups and outcomes, adjusting for Child–Pugh class, age, gender, and comorbidity. Results: Nine patients who trained and 15 controls were hospitalized, resulting in a lower risk of first hospitalization in the training group (adjusted subdistribution hazard ratio of 0.40, 95% confidence interval [CI] [0.17, 0.92]; P = 0.03). One patient who trained and six controls died, resulting in a lower all-cause mortality in the training group (adjusted hazard ratio of 0.06, 95% CI [0.01, 0.66]; P = 0.02). Conclusion: Twelve weeks of resistance training was associated with a reduced risk of first hospitalization and mortality among patients with cirrhosis Child–Pugh class A/B 3 years after trial entry. The mechanisms of this effect are not identified, and larger studies are warranted.",

keywords = "Chronic liver disease, Cirrhosis, Exercise, Morbidity, Physical activity, Sarcopenia, Survival, Training, Liver Cirrhosis/complications, Follow-Up Studies, Humans, Hospitalization, Resistance Training, Hospitals, Fibrosis",

author = "Luise Aamann and Gitte Dam and Peter Jepsen and Mette Borre and Aska Drljevic-Nielsen and Kristian Overgaard and Henning Andersen and Hendrik Vilstrup and Aagaard, {Niels Kristian}",

year = "2023",

month = aug,

doi = "10.1111/jgh.16141",

language = "English",

volume = "38",

pages = "1365--1371",

journal = "Journal of Gastroenterology and Hepatology",

issn = "0815-9319",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "8",

}

Aamann, L , Dam, G , Jepsen, P , Borre, M, Drljevic-Nielsen, A, Overgaard, K , Andersen, H , Vilstrup, H & Aagaard, NK 2023, 'Reduced 3-year risk of hospital admission and mortality after 12-week resistance training of cirrhosis patients: A follow-up of a randomized clinical trial', Journal of Gastroenterology and Hepatology, vol. 38, no. 8, pp. 1365-1371. https://doi.org/10.1111/jgh.16141

Reduced 3-year risk of hospital admission and mortality after 12-week resistance training of cirrhosis patients: A follow-up of a randomized clinical trial. / Aamann, Luise ; Dam, Gitte ; Jepsen, Peter et al.
In: Journal of Gastroenterology and Hepatology, Vol. 38, No. 8, 08.2023, p. 1365-1371.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Reduced 3-year risk of hospital admission and mortality after 12-week resistance training of cirrhosis patients

T2 - A follow-up of a randomized clinical trial

AU - Aamann, Luise

AU - Dam, Gitte

AU - Jepsen, Peter

AU - Borre, Mette

AU - Drljevic-Nielsen, Aska

AU - Overgaard, Kristian

AU - Andersen, Henning

AU - Vilstrup, Hendrik

AU - Aagaard, Niels Kristian

PY - 2023/8

Y1 - 2023/8

N2 - Background and Aim: Physical activity confers health benefits in many diseases but remains almost unstudied for cirrhosis. We investigated whether a period of resistance training affects the subsequent long-term risk of hospitalization or mortality among patients with cirrhosis. Methods: The study includes 39 participants with cirrhosis Child–Pugh class A/B who participated in a prior clinical trial randomized to either resistance training three times per week for 12 weeks or a control group. We gathered data through medical records from trial entry and the following 3 years. The outcomes were time to first hospitalization and all-cause mortality. We used regression models to examine the associations between trial groups and outcomes, adjusting for Child–Pugh class, age, gender, and comorbidity. Results: Nine patients who trained and 15 controls were hospitalized, resulting in a lower risk of first hospitalization in the training group (adjusted subdistribution hazard ratio of 0.40, 95% confidence interval [CI] [0.17, 0.92]; P = 0.03). One patient who trained and six controls died, resulting in a lower all-cause mortality in the training group (adjusted hazard ratio of 0.06, 95% CI [0.01, 0.66]; P = 0.02). Conclusion: Twelve weeks of resistance training was associated with a reduced risk of first hospitalization and mortality among patients with cirrhosis Child–Pugh class A/B 3 years after trial entry. The mechanisms of this effect are not identified, and larger studies are warranted.

AB - Background and Aim: Physical activity confers health benefits in many diseases but remains almost unstudied for cirrhosis. We investigated whether a period of resistance training affects the subsequent long-term risk of hospitalization or mortality among patients with cirrhosis. Methods: The study includes 39 participants with cirrhosis Child–Pugh class A/B who participated in a prior clinical trial randomized to either resistance training three times per week for 12 weeks or a control group. We gathered data through medical records from trial entry and the following 3 years. The outcomes were time to first hospitalization and all-cause mortality. We used regression models to examine the associations between trial groups and outcomes, adjusting for Child–Pugh class, age, gender, and comorbidity. Results: Nine patients who trained and 15 controls were hospitalized, resulting in a lower risk of first hospitalization in the training group (adjusted subdistribution hazard ratio of 0.40, 95% confidence interval [CI] [0.17, 0.92]; P = 0.03). One patient who trained and six controls died, resulting in a lower all-cause mortality in the training group (adjusted hazard ratio of 0.06, 95% CI [0.01, 0.66]; P = 0.02). Conclusion: Twelve weeks of resistance training was associated with a reduced risk of first hospitalization and mortality among patients with cirrhosis Child–Pugh class A/B 3 years after trial entry. The mechanisms of this effect are not identified, and larger studies are warranted.

KW - Chronic liver disease

KW - Cirrhosis

KW - Exercise

KW - Morbidity

KW - Physical activity

KW - Sarcopenia

KW - Survival

KW - Training

KW - Liver Cirrhosis/complications

KW - Follow-Up Studies

KW - Humans

KW - Hospitalization

KW - Resistance Training

KW - Hospitals

KW - Fibrosis

U2 - 10.1111/jgh.16141

DO - 10.1111/jgh.16141

M3 - Journal article

C2 - 36740964

SN - 0815-9319

VL - 38

SP - 1365

EP - 1371

JO - Journal of Gastroenterology and Hepatology

JF - Journal of Gastroenterology and Hepatology

IS - 8

ER -

Reduced 3-year risk of hospital admission and mortality after 12-week resistance training of cirrhosis patients: A follow-up of a randomized clinical trial

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