Reduced 3-year risk of hospital admission and mortality after 12-week resistance training of cirrhosis patients: A follow-up of a randomized clinical trial

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Abstract

Background and Aim: Physical activity confers health benefits in many diseases but remains almost unstudied for cirrhosis. We investigated whether a period of resistance training affects the subsequent long-term risk of hospitalization or mortality among patients with cirrhosis. Methods: The study includes 39 participants with cirrhosis Child–Pugh class A/B who participated in a prior clinical trial randomized to either resistance training three times per week for 12 weeks or a control group. We gathered data through medical records from trial entry and the following 3 years. The outcomes were time to first hospitalization and all-cause mortality. We used regression models to examine the associations between trial groups and outcomes, adjusting for Child–Pugh class, age, gender, and comorbidity. Results: Nine patients who trained and 15 controls were hospitalized, resulting in a lower risk of first hospitalization in the training group (adjusted subdistribution hazard ratio of 0.40, 95% confidence interval [CI] [0.17, 0.92]; P = 0.03). One patient who trained and six controls died, resulting in a lower all-cause mortality in the training group (adjusted hazard ratio of 0.06, 95% CI [0.01, 0.66]; P = 0.02). Conclusion: Twelve weeks of resistance training was associated with a reduced risk of first hospitalization and mortality among patients with cirrhosis Child–Pugh class A/B 3 years after trial entry. The mechanisms of this effect are not identified, and larger studies are warranted.

Original languageEnglish
JournalJournal of Gastroenterology and Hepatology
Volume38
Issue8
Pages (from-to)1365-1371
Number of pages7
ISSN0815-9319
DOIs
Publication statusPublished - Aug 2023

Keywords

  • Chronic liver disease
  • Cirrhosis
  • Exercise
  • Morbidity
  • Physical activity
  • Sarcopenia
  • Survival
  • Training
  • Liver Cirrhosis/complications
  • Follow-Up Studies
  • Humans
  • Hospitalization
  • Resistance Training
  • Hospitals
  • Fibrosis

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