Recycling and Imaging of Nuclear Singlet Hyperpolarization

Giuseppe Pileio, Sean Bowen, Christoffer Laustsen, Michael C D Tayler, Joseph T Hill-Cousins, Lynda Jane Brown, Richard Charles Downie Brown, Jan Henrik Ardenkjær-Larsen, Malcolm H Levitt

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The strong enhancement of NMR signals achieved by hyperpolarization, decays, at best, with a time constant of a few minutes. Here we show that a combination of long-lived singlet states, molecular design, magnetic field cycling, and specific radiofrequency pulse sequences, allows repeated observation of the same batch of polarized nuclei over a period of 30 minutes and more. We report a recycling protocol in which the enhanced nuclear polarization achieved by dissolution-DNP is observed with full intensity and then returned to singlet order. E.g. MRI experiments may be run on a portion of the available spin polarization while the remaining is preserved and made available for a later use. An analogy is drawn with a "spin bank" or "resealable container" in which highly polarized spin order may be deposited and retrieved.
Original languageEnglish
Article number135/13
JournalJournal of the American Chemical Society
Pages (from-to)5084–5088
Number of pages5
Publication statusPublished - 15 Mar 2013


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