Recurrence risk of congenital anomalies - the impact of paternal, social, and environmental factors: A population-based study in Denmark

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  • Olga Basso, Denmark
  • Jørn Olsen
  • Kaare Christensen, Denmark
  • Institute of Epidemiology and Social Medicine
  • The Danish Epidemiology Science Centre
The authors investigated the recurrence risk of congenital anomalies as a function of changes in genetic and environmental factors in single births following the birth of a child with an anomaly. The study is a population-based historical follow-up using the Danish Medical Birth registry, hospital discharge diagnoses, and Statistic Denmark's Fertility Database. The investigators identified 8,671 women who gave birth to a child with a diagnosed malformation between 1980 and 1992 and had a subsequent birth. Following the birth of an affected infant, 474 (5.5%) women gave birth to another child with a malformation, 155 of which (1.8%) were similar to the malformation of the older sib or half sib. When the father changed between the two births, the risk of a similar anomaly was significantly reduced (odds ratio (OR) = 0.26, 95% confidence interval (CI) 0.11, 0.65). Higher social status at enrollment was associated with a lower recurrence risk (OR = 0.67, 95% CI 0.45, 0.99, for the middle status group and OR = 0.49, 95% CI 0.30, 0.81, for the highest status group), independently of partner change. A rise in social status between the two births was marginally associated with a decline in the recurrence risk. No variation in the recurrence risk associated with change of municipality or occupation was seen.
Original languageEnglish
JournalAmerican Journal of Epidemiology
Volume150
Issue6
Pages (from-to)598-604
Number of pages7
ISSN0002-9262
Publication statusPublished - 15 Sep 1999

    Research areas

  • abnormalities, cohort studies, environmental exposure, follow-up studies, paternal exposure, risk, social class, socioeconomic factors

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