Recurrence Risk of Autism in Siblings and Cousins: A Multinational, Population-Based Study

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Recurrence Risk of Autism in Siblings and Cousins : A Multinational, Population-Based Study. / Hansen, Stefan N; Schendel, Diana E; Francis, Richard W; Windham, Gayle C; Bresnahan, Michaeline; Levine, Stephen Z; Reichenberg, Abraham; Gissler, Mika; Kodesh, Arad; Bai, Dan; Yip, Benjamin Hon Kei; Leonard, Helen; Sandin, Sven; Buxbaum, Joseph D; Hultman, Christina; Sourander, Andre; Glasson, Emma J; Wong, Kingsley; Öberg, Rikard; Parner, Erik T.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 58, No. 9, 09.2019, p. 866-875.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Hansen, SN, Schendel, DE, Francis, RW, Windham, GC, Bresnahan, M, Levine, SZ, Reichenberg, A, Gissler, M, Kodesh, A, Bai, D, Yip, BHK, Leonard, H, Sandin, S, Buxbaum, JD, Hultman, C, Sourander, A, Glasson, EJ, Wong, K, Öberg, R & Parner, ET 2019, 'Recurrence Risk of Autism in Siblings and Cousins: A Multinational, Population-Based Study', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 58, no. 9, pp. 866-875. https://doi.org/10.1016/j.jaac.2018.11.017

APA

Hansen, S. N., Schendel, D. E., Francis, R. W., Windham, G. C., Bresnahan, M., Levine, S. Z., Reichenberg, A., Gissler, M., Kodesh, A., Bai, D., Yip, B. H. K., Leonard, H., Sandin, S., Buxbaum, J. D., Hultman, C., Sourander, A., Glasson, E. J., Wong, K., Öberg, R., & Parner, E. T. (2019). Recurrence Risk of Autism in Siblings and Cousins: A Multinational, Population-Based Study. Journal of the American Academy of Child and Adolescent Psychiatry, 58(9), 866-875. https://doi.org/10.1016/j.jaac.2018.11.017

CBE

Hansen SN, Schendel DE, Francis RW, Windham GC, Bresnahan M, Levine SZ, Reichenberg A, Gissler M, Kodesh A, Bai D, Yip BHK, Leonard H, Sandin S, Buxbaum JD, Hultman C, Sourander A, Glasson EJ, Wong K, Öberg R, Parner ET. 2019. Recurrence Risk of Autism in Siblings and Cousins: A Multinational, Population-Based Study. Journal of the American Academy of Child and Adolescent Psychiatry. 58(9):866-875. https://doi.org/10.1016/j.jaac.2018.11.017

MLA

Hansen, Stefan N et al. "Recurrence Risk of Autism in Siblings and Cousins: A Multinational, Population-Based Study". Journal of the American Academy of Child and Adolescent Psychiatry. 2019, 58(9). 866-875. https://doi.org/10.1016/j.jaac.2018.11.017

Vancouver

Hansen SN, Schendel DE, Francis RW, Windham GC, Bresnahan M, Levine SZ et al. Recurrence Risk of Autism in Siblings and Cousins: A Multinational, Population-Based Study. Journal of the American Academy of Child and Adolescent Psychiatry. 2019 Sep;58(9):866-875. https://doi.org/10.1016/j.jaac.2018.11.017

Author

Hansen, Stefan N ; Schendel, Diana E ; Francis, Richard W ; Windham, Gayle C ; Bresnahan, Michaeline ; Levine, Stephen Z ; Reichenberg, Abraham ; Gissler, Mika ; Kodesh, Arad ; Bai, Dan ; Yip, Benjamin Hon Kei ; Leonard, Helen ; Sandin, Sven ; Buxbaum, Joseph D ; Hultman, Christina ; Sourander, Andre ; Glasson, Emma J ; Wong, Kingsley ; Öberg, Rikard ; Parner, Erik T. / Recurrence Risk of Autism in Siblings and Cousins : A Multinational, Population-Based Study. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2019 ; Vol. 58, No. 9. pp. 866-875.

Bibtex

@article{7f87483287d44148ae1f3dad7d433caa,
title = "Recurrence Risk of Autism in Siblings and Cousins: A Multinational, Population-Based Study",
abstract = "OBJECTIVE: Familial recurrence risk is an important population-level measure of the combined genetic and shared familial liability of autism spectrum disorder (ASD). Objectives were to estimate ASD recurrence risk among siblings and cousins by varying degree of relatedness and by sex.METHOD: Population-based cohort study of 1998-2007 livebirths from California, Denmark, Finland, Israel, Sweden and Western Australia followed through 2011-2015. Subjects were monitored for an ASD diagnosis in their older siblings or cousins (exposure) and for their own ASD diagnosis (outcome). The relative recurrence risk was estimated for different sibling- and cousin-pairs, for each site separately and combined, and by sex.RESULTS: During follow-up, 29,998 cases of ASD were observed among the 2,551,918 births used to estimate recurrence in ASD and 33,769 cases of childhood autism (CA) were observed among the 6,110,942 births used to estimate CA recurrence. Compared to the risk in unaffected families, we observed an 8.4-fold increase in the risk of ASD following an older sibling with ASD and an 17.4-fold increase in the risk of CA following an older sibling with CA. A 2-fold increase in the risk for cousin recurrence was observed for both disorders. We also found a significant difference in sibling ASD recurrence risk by sex.CONCLUSION: Our estimates of relative recurrence risks for ASD and CA will assist clinicians and families in understanding autism risk in the context of other families in their population. The observed variation by sex underlines the need to deepen our understanding of factors influencing ASD familial risk.",
keywords = "autism, familial risk, longitudinal, multinational, recurrence",
author = "Hansen, {Stefan N} and Schendel, {Diana E} and Francis, {Richard W} and Windham, {Gayle C} and Michaeline Bresnahan and Levine, {Stephen Z} and Abraham Reichenberg and Mika Gissler and Arad Kodesh and Dan Bai and Yip, {Benjamin Hon Kei} and Helen Leonard and Sven Sandin and Buxbaum, {Joseph D} and Christina Hultman and Andre Sourander and Glasson, {Emma J} and Kingsley Wong and Rikard {\"O}berg and Parner, {Erik T}",
note = "Copyright {\textcopyright} 2019 American Academy of Child and Adolescent Psychiatry. All rights reserved.",
year = "2019",
month = sep,
doi = "10.1016/j.jaac.2018.11.017",
language = "English",
volume = "58",
pages = "866--875",
journal = "American Academy of Child and Adolescent Psychiatry. Journal",
issn = "0890-8567",
publisher = "Elsevier BV",
number = "9",

}

RIS

TY - JOUR

T1 - Recurrence Risk of Autism in Siblings and Cousins

T2 - A Multinational, Population-Based Study

AU - Hansen, Stefan N

AU - Schendel, Diana E

AU - Francis, Richard W

AU - Windham, Gayle C

AU - Bresnahan, Michaeline

AU - Levine, Stephen Z

AU - Reichenberg, Abraham

AU - Gissler, Mika

AU - Kodesh, Arad

AU - Bai, Dan

AU - Yip, Benjamin Hon Kei

AU - Leonard, Helen

AU - Sandin, Sven

AU - Buxbaum, Joseph D

AU - Hultman, Christina

AU - Sourander, Andre

AU - Glasson, Emma J

AU - Wong, Kingsley

AU - Öberg, Rikard

AU - Parner, Erik T

N1 - Copyright © 2019 American Academy of Child and Adolescent Psychiatry. All rights reserved.

PY - 2019/9

Y1 - 2019/9

N2 - OBJECTIVE: Familial recurrence risk is an important population-level measure of the combined genetic and shared familial liability of autism spectrum disorder (ASD). Objectives were to estimate ASD recurrence risk among siblings and cousins by varying degree of relatedness and by sex.METHOD: Population-based cohort study of 1998-2007 livebirths from California, Denmark, Finland, Israel, Sweden and Western Australia followed through 2011-2015. Subjects were monitored for an ASD diagnosis in their older siblings or cousins (exposure) and for their own ASD diagnosis (outcome). The relative recurrence risk was estimated for different sibling- and cousin-pairs, for each site separately and combined, and by sex.RESULTS: During follow-up, 29,998 cases of ASD were observed among the 2,551,918 births used to estimate recurrence in ASD and 33,769 cases of childhood autism (CA) were observed among the 6,110,942 births used to estimate CA recurrence. Compared to the risk in unaffected families, we observed an 8.4-fold increase in the risk of ASD following an older sibling with ASD and an 17.4-fold increase in the risk of CA following an older sibling with CA. A 2-fold increase in the risk for cousin recurrence was observed for both disorders. We also found a significant difference in sibling ASD recurrence risk by sex.CONCLUSION: Our estimates of relative recurrence risks for ASD and CA will assist clinicians and families in understanding autism risk in the context of other families in their population. The observed variation by sex underlines the need to deepen our understanding of factors influencing ASD familial risk.

AB - OBJECTIVE: Familial recurrence risk is an important population-level measure of the combined genetic and shared familial liability of autism spectrum disorder (ASD). Objectives were to estimate ASD recurrence risk among siblings and cousins by varying degree of relatedness and by sex.METHOD: Population-based cohort study of 1998-2007 livebirths from California, Denmark, Finland, Israel, Sweden and Western Australia followed through 2011-2015. Subjects were monitored for an ASD diagnosis in their older siblings or cousins (exposure) and for their own ASD diagnosis (outcome). The relative recurrence risk was estimated for different sibling- and cousin-pairs, for each site separately and combined, and by sex.RESULTS: During follow-up, 29,998 cases of ASD were observed among the 2,551,918 births used to estimate recurrence in ASD and 33,769 cases of childhood autism (CA) were observed among the 6,110,942 births used to estimate CA recurrence. Compared to the risk in unaffected families, we observed an 8.4-fold increase in the risk of ASD following an older sibling with ASD and an 17.4-fold increase in the risk of CA following an older sibling with CA. A 2-fold increase in the risk for cousin recurrence was observed for both disorders. We also found a significant difference in sibling ASD recurrence risk by sex.CONCLUSION: Our estimates of relative recurrence risks for ASD and CA will assist clinicians and families in understanding autism risk in the context of other families in their population. The observed variation by sex underlines the need to deepen our understanding of factors influencing ASD familial risk.

KW - autism

KW - familial risk

KW - longitudinal

KW - multinational

KW - recurrence

U2 - 10.1016/j.jaac.2018.11.017

DO - 10.1016/j.jaac.2018.11.017

M3 - Journal article

C2 - 30851399

VL - 58

SP - 866

EP - 875

JO - American Academy of Child and Adolescent Psychiatry. Journal

JF - American Academy of Child and Adolescent Psychiatry. Journal

SN - 0890-8567

IS - 9

ER -