Recurrence rate after radical prostatectomy following primary staging of high-risk prostate cancer with 68Ga-PSMA PET/CT

Søren Klingenberg; Jacob Hesselvig Fredsøe; Karina Dalsgaard Sørensen; Benedicte Parm Ulhøi; Michael Borre; Mads Ryø Jochumsen; Kirsten Bouchelouche

doi:10.1080/0284186X.2022.2129442

Recurrence rate after radical prostatectomy following primary staging of high-risk prostate cancer with 68Ga-PSMA PET/CT

Søren Klingenberg^*, Jacob Hesselvig Fredsøe, Karina Dalsgaard Sørensen, Benedicte Parm Ulhøi, Michael Borre, Mads Ryø Jochumsen, Kirsten Bouchelouche

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

7 Citations (Scopus)

Abstract

Background: Accurate primary staging is one of the most important issues for initial management of prostate cancer (PCa) patients to perform an optimal selection of patients for curative intended treatment. ⁶⁸Ga-Prostate-Specific-Membrane-Antigen (PSMA) PET/CT was found superior to conventional imaging both for detection of recurrence after curative intended treatment and for primary staging. We studied the recurrence rate after radical prostatectomy in high-risk PCa patients primary staged with ⁶⁸Ga-PSMA PET/CT compared with conventional imaging. Material and methods: The study included 247 D’Amico high-risk PCa patients treated with radical prostatectomy (RP) after primary staging with ⁶⁸Ga-PSMA PET/CT and a reference group of 137 high-risk patients with RP after conventional imaging (^99mTc bone scintigraphy and CT). Recurrence rates were assessed by Cox regression and Kaplan-Meier analysis. Results: The 5-year recurrence-free survival rate was 71.1% in the ⁶⁸Ga-PSMA PET/CT cohort compared with 56.4% in the conventional imaging cohort. Primary staging by ⁶⁸Ga-PSMA PET/CT reduced biochemical recurrence (BCR) risk by 42% (HR = 0.58 (0.41–0.83), p =.004). Conclusion: The present data could indicate a lower recurrence rate after RP following primary staging with ⁶⁸Ga-PSMA PET/CT compared to conventional imaging, likely due to improved selection of patients for surgery.

Original language	English
Journal	Acta Oncologica
Volume	61
Issue	10
Pages (from-to)	1289-1294
Number of pages	6
ISSN	0284-186X
DOIs	https://doi.org/10.1080/0284186X.2022.2129442
Publication status	Published - Nov 2022

Keywords

Ga-prostate-specific membrane antigen PET/CT
biochemical recurrence
primary staging
prostate cancer
radical prostatectomy

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10.1080/0284186X.2022.2129442

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@article{dcb18888decd4bf087f084e03a1c4353,

title = "Recurrence rate after radical prostatectomy following primary staging of high-risk prostate cancer with 68Ga-PSMA PET/CT",

abstract = "Background: Accurate primary staging is one of the most important issues for initial management of prostate cancer (PCa) patients to perform an optimal selection of patients for curative intended treatment. 68Ga-Prostate-Specific-Membrane-Antigen (PSMA) PET/CT was found superior to conventional imaging both for detection of recurrence after curative intended treatment and for primary staging. We studied the recurrence rate after radical prostatectomy in high-risk PCa patients primary staged with 68Ga-PSMA PET/CT compared with conventional imaging. Material and methods: The study included 247 D{\textquoteright}Amico high-risk PCa patients treated with radical prostatectomy (RP) after primary staging with 68Ga-PSMA PET/CT and a reference group of 137 high-risk patients with RP after conventional imaging (99mTc bone scintigraphy and CT). Recurrence rates were assessed by Cox regression and Kaplan-Meier analysis. Results: The 5-year recurrence-free survival rate was 71.1% in the 68Ga-PSMA PET/CT cohort compared with 56.4% in the conventional imaging cohort. Primary staging by 68Ga-PSMA PET/CT reduced biochemical recurrence (BCR) risk by 42% (HR = 0.58 (0.41–0.83), p =.004). Conclusion: The present data could indicate a lower recurrence rate after RP following primary staging with 68Ga-PSMA PET/CT compared to conventional imaging, likely due to improved selection of patients for surgery.",

keywords = "Ga-prostate-specific membrane antigen PET/CT, biochemical recurrence, primary staging, prostate cancer, radical prostatectomy",

author = "S{\o}ren Klingenberg and Freds{\o}e, {Jacob Hesselvig} and S{\o}rensen, {Karina Dalsgaard} and Ulh{\o}i, {Benedicte Parm} and Michael Borre and Jochumsen, {Mads Ry{\o}} and Kirsten Bouchelouche",

year = "2022",

month = nov,

doi = "10.1080/0284186X.2022.2129442",

language = "English",

volume = "61",

pages = "1289--1294",

journal = "Acta Oncologica",

issn = "0284-186X",

publisher = "Medical Journals Sweden AB",

number = "10",

}

Recurrence rate after radical prostatectomy following primary staging of high-risk prostate cancer with 68Ga-PSMA PET/CT. / Klingenberg, Søren; Fredsøe, Jacob Hesselvig; Sørensen, Karina Dalsgaard et al.
In: Acta Oncologica, Vol. 61, No. 10, 11.2022, p. 1289-1294.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Recurrence rate after radical prostatectomy following primary staging of high-risk prostate cancer with 68Ga-PSMA PET/CT

AU - Klingenberg, Søren

AU - Fredsøe, Jacob Hesselvig

AU - Sørensen, Karina Dalsgaard

AU - Ulhøi, Benedicte Parm

AU - Borre, Michael

AU - Jochumsen, Mads Ryø

AU - Bouchelouche, Kirsten

PY - 2022/11

Y1 - 2022/11

N2 - Background: Accurate primary staging is one of the most important issues for initial management of prostate cancer (PCa) patients to perform an optimal selection of patients for curative intended treatment. 68Ga-Prostate-Specific-Membrane-Antigen (PSMA) PET/CT was found superior to conventional imaging both for detection of recurrence after curative intended treatment and for primary staging. We studied the recurrence rate after radical prostatectomy in high-risk PCa patients primary staged with 68Ga-PSMA PET/CT compared with conventional imaging. Material and methods: The study included 247 D’Amico high-risk PCa patients treated with radical prostatectomy (RP) after primary staging with 68Ga-PSMA PET/CT and a reference group of 137 high-risk patients with RP after conventional imaging (99mTc bone scintigraphy and CT). Recurrence rates were assessed by Cox regression and Kaplan-Meier analysis. Results: The 5-year recurrence-free survival rate was 71.1% in the 68Ga-PSMA PET/CT cohort compared with 56.4% in the conventional imaging cohort. Primary staging by 68Ga-PSMA PET/CT reduced biochemical recurrence (BCR) risk by 42% (HR = 0.58 (0.41–0.83), p =.004). Conclusion: The present data could indicate a lower recurrence rate after RP following primary staging with 68Ga-PSMA PET/CT compared to conventional imaging, likely due to improved selection of patients for surgery.

AB - Background: Accurate primary staging is one of the most important issues for initial management of prostate cancer (PCa) patients to perform an optimal selection of patients for curative intended treatment. 68Ga-Prostate-Specific-Membrane-Antigen (PSMA) PET/CT was found superior to conventional imaging both for detection of recurrence after curative intended treatment and for primary staging. We studied the recurrence rate after radical prostatectomy in high-risk PCa patients primary staged with 68Ga-PSMA PET/CT compared with conventional imaging. Material and methods: The study included 247 D’Amico high-risk PCa patients treated with radical prostatectomy (RP) after primary staging with 68Ga-PSMA PET/CT and a reference group of 137 high-risk patients with RP after conventional imaging (99mTc bone scintigraphy and CT). Recurrence rates were assessed by Cox regression and Kaplan-Meier analysis. Results: The 5-year recurrence-free survival rate was 71.1% in the 68Ga-PSMA PET/CT cohort compared with 56.4% in the conventional imaging cohort. Primary staging by 68Ga-PSMA PET/CT reduced biochemical recurrence (BCR) risk by 42% (HR = 0.58 (0.41–0.83), p =.004). Conclusion: The present data could indicate a lower recurrence rate after RP following primary staging with 68Ga-PSMA PET/CT compared to conventional imaging, likely due to improved selection of patients for surgery.

KW - Ga-prostate-specific membrane antigen PET/CT

KW - biochemical recurrence

KW - primary staging

KW - prostate cancer

KW - radical prostatectomy

UR - http://www.scopus.com/inward/record.url?scp=85139610802&partnerID=8YFLogxK

U2 - 10.1080/0284186X.2022.2129442

DO - 10.1080/0284186X.2022.2129442

M3 - Journal article

C2 - 36199168

SN - 0284-186X

VL - 61

SP - 1289

EP - 1294

JO - Acta Oncologica

JF - Acta Oncologica

IS - 10

ER -

Recurrence rate after radical prostatectomy following primary staging of high-risk prostate cancer with 68Ga-PSMA PET/CT

Abstract

Keywords

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