Recovery of Moderate Coronavirus Disease 2019 in a Liver Transplant Recipient on Continued Immunosuppression: A Case Report

Victor Dahl Mathiasen; Stine Karlsen Oversoe; Peter Ott; Søren Jensen-Fangel; Steffen Leth

doi:10.1016/j.transproceed.2020.09.007

Recovery of Moderate Coronavirus Disease 2019 in a Liver Transplant Recipient on Continued Immunosuppression: A Case Report

Victor Dahl Mathiasen^*, Stine Karlsen Oversoe, Peter Ott, Søren Jensen-Fangel, Steffen Leth

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

4 Citations (Scopus)

Abstract

The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had an enormous impact on the world. Owing to limited data available, it remains unclear to what extent liver transplant recipients should be considered at a higher risk of severe disease. We describe a moderate course of coronavirus disease 2019 (COVID-19) in a patient who underwent a liver transplant 2 years earlier because of Budd-Chiari syndrome. The patient presented with malaise, headache, dry cough, and fever for 4 days. Immunosuppressive therapy with tacrolimus and mycophenolate mofetil was continued throughout the course of infection. Oxygen therapy was given for a single night, and the patient gradually recovered with supportive care only. With this case report, we demonstrate that liver transplantation and immunosuppression is not necessarily associated with severe COVID-19 and emphasize that more information on this matter is urgently required. Withdrawal of immunosuppressive therapy could be associated with higher mortality.

Original language	English
Journal	Transplantation Proceedings
Volume	52
Issue	9
Pages (from-to)	2703-2706
Number of pages	4
ISSN	0041-1345
DOIs	https://doi.org/10.1016/j.transproceed.2020.09.007
Publication status	Published - Nov 2020

Keywords

Betacoronavirus
Coronavirus Infections/immunology
Female
Humans
Immunocompromised Host
Immunosuppressive Agents/therapeutic use
Liver Transplantation
Middle Aged
Pandemics
Pneumonia, Viral/immunology

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498236/pdf/main.pdf

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title = "Recovery of Moderate Coronavirus Disease 2019 in a Liver Transplant Recipient on Continued Immunosuppression: A Case Report",

abstract = "The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had an enormous impact on the world. Owing to limited data available, it remains unclear to what extent liver transplant recipients should be considered at a higher risk of severe disease. We describe a moderate course of coronavirus disease 2019 (COVID-19) in a patient who underwent a liver transplant 2 years earlier because of Budd-Chiari syndrome. The patient presented with malaise, headache, dry cough, and fever for 4 days. Immunosuppressive therapy with tacrolimus and mycophenolate mofetil was continued throughout the course of infection. Oxygen therapy was given for a single night, and the patient gradually recovered with supportive care only. With this case report, we demonstrate that liver transplantation and immunosuppression is not necessarily associated with severe COVID-19 and emphasize that more information on this matter is urgently required. Withdrawal of immunosuppressive therapy could be associated with higher mortality.",

keywords = "Betacoronavirus, Coronavirus Infections/immunology, Female, Humans, Immunocompromised Host, Immunosuppressive Agents/therapeutic use, Liver Transplantation, Middle Aged, Pandemics, Pneumonia, Viral/immunology",

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year = "2020",

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doi = "10.1016/j.transproceed.2020.09.007",

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Recovery of Moderate Coronavirus Disease 2019 in a Liver Transplant Recipient on Continued Immunosuppression: A Case Report. / Mathiasen, Victor Dahl; Oversoe, Stine Karlsen; Ott, Peter et al.
In: Transplantation Proceedings, Vol. 52, No. 9, 11.2020, p. 2703-2706.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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AU - Jensen-Fangel, Søren

AU - Leth, Steffen

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KW - Immunocompromised Host

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KW - Liver Transplantation

KW - Middle Aged

KW - Pandemics

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Recovery of Moderate Coronavirus Disease 2019 in a Liver Transplant Recipient on Continued Immunosuppression: A Case Report

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