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Receptor-based in vitro activities to assess human exposure to chemical mixtures and related health impacts

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Standard

Receptor-based in vitro activities to assess human exposure to chemical mixtures and related health impacts. / Vinggaard, Anne Marie; Bonefeld-Jørgensen, Eva Cecilie; Jensen, Tina Kold; Fernandez, Mariana F; Rosenmai, Anna Kjerstine; Taxvig, Camilla; Rodriguez-Carrillo, Andrea; Wielsøe, Maria; Long, Manhai; Olea, Nicolas; Antignac, Jean-Philippe; Hamers, Timo; Lamoree, Marja.

In: Environment International, Vol. 146, 106191, 01.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Harvard

Vinggaard, AM, Bonefeld-Jørgensen, EC, Jensen, TK, Fernandez, MF, Rosenmai, AK, Taxvig, C, Rodriguez-Carrillo, A, Wielsøe, M, Long, M, Olea, N, Antignac, J-P, Hamers, T & Lamoree, M 2021, 'Receptor-based in vitro activities to assess human exposure to chemical mixtures and related health impacts', Environment International, vol. 146, 106191. https://doi.org/10.1016/j.envint.2020.106191

APA

Vinggaard, A. M., Bonefeld-Jørgensen, E. C., Jensen, T. K., Fernandez, M. F., Rosenmai, A. K., Taxvig, C., Rodriguez-Carrillo, A., Wielsøe, M., Long, M., Olea, N., Antignac, J-P., Hamers, T., & Lamoree, M. (2021). Receptor-based in vitro activities to assess human exposure to chemical mixtures and related health impacts. Environment International, 146, [106191]. https://doi.org/10.1016/j.envint.2020.106191

CBE

Vinggaard AM, Bonefeld-Jørgensen EC, Jensen TK, Fernandez MF, Rosenmai AK, Taxvig C, Rodriguez-Carrillo A, Wielsøe M, Long M, Olea N, Antignac J-P, Hamers T, Lamoree M. 2021. Receptor-based in vitro activities to assess human exposure to chemical mixtures and related health impacts. Environment International. 146:Article 106191. https://doi.org/10.1016/j.envint.2020.106191

MLA

Vancouver

Vinggaard AM, Bonefeld-Jørgensen EC, Jensen TK, Fernandez MF, Rosenmai AK, Taxvig C et al. Receptor-based in vitro activities to assess human exposure to chemical mixtures and related health impacts. Environment International. 2021 Jan;146. 106191. https://doi.org/10.1016/j.envint.2020.106191

Author

Vinggaard, Anne Marie ; Bonefeld-Jørgensen, Eva Cecilie ; Jensen, Tina Kold ; Fernandez, Mariana F ; Rosenmai, Anna Kjerstine ; Taxvig, Camilla ; Rodriguez-Carrillo, Andrea ; Wielsøe, Maria ; Long, Manhai ; Olea, Nicolas ; Antignac, Jean-Philippe ; Hamers, Timo ; Lamoree, Marja. / Receptor-based in vitro activities to assess human exposure to chemical mixtures and related health impacts. In: Environment International. 2021 ; Vol. 146.

Bibtex

@article{7be4adc34ee441c6960e608b0678f407,
title = "Receptor-based in vitro activities to assess human exposure to chemical mixtures and related health impacts",
abstract = "Humans are exposed to a large number of chemicals from sources such as the environment, food, and consumer products. There is growing concern that human exposure to chemical mixtures, especially during critical periods of development, increases the risk of adverse health effects in newborns or later in life. Historically, the one-chemical-at-a-time approach has been applied both for exposure assessment and hazard characterisation, leading to insufficient knowledge about human health effects caused by exposure to mixtures of chemicals that have the same target. To circumvent this challenge researchers can apply in vitro assays to analyse both exposure to and human health effects of chemical mixtures in biological samples. The advantages of using in vitro assays are: (i) that an integrated effect is measured, taking combined mixture effects into account and (ii) that in vitro assays can reduce complexity in identification of Chemicals of Emerging Concern (CECs) in human tissues. We have reviewed the state-of-the-art on the use of receptor-based in vitro assays to assess human exposure to chemical mixtures and related health impacts. A total of 43 studies were identified, in which endpoints for the arylhydrocarbon receptor (AhR), the estrogen receptor (ER), and the androgen receptor (AR) were used. The majority of studies reported biological activities that could be associated with breast cancer incidence, male reproductive health effects, developmental toxicities, human demographic characteristics or lifestyle factors such as dietary patterns. A few studies used the bioactivities to check the coverage of the chemical analyses of the human samples, whereas in vitro assays have so far not regularly been used for identifying CECs in human samples, but rather in environmental matrices or food packaging materials. A huge field of novel applications using receptor-based in vitro assays for mixture toxicity assessment on human samples and effect-directed analysis (EDA) using high resolution mass spectrometry (HRMS) for identification of toxic compounds waits for exploration. In the future this could lead to a paradigm shift in the way we unravel adverse human health effects caused by chemical mixtures.",
keywords = "in vitro assays, biomarker, effect-directed analysis, human diseases, human health, mixtures",
author = "Vinggaard, {Anne Marie} and Bonefeld-J{\o}rgensen, {Eva Cecilie} and Jensen, {Tina Kold} and Fernandez, {Mariana F} and Rosenmai, {Anna Kjerstine} and Camilla Taxvig and Andrea Rodriguez-Carrillo and Maria Wiels{\o}e and Manhai Long and Nicolas Olea and Jean-Philippe Antignac and Timo Hamers and Marja Lamoree",
note = "Copyright {\textcopyright} 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.",
year = "2021",
month = jan,
doi = "10.1016/j.envint.2020.106191",
language = "English",
volume = "146",
journal = "Environment International",
issn = "0160-4120",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Receptor-based in vitro activities to assess human exposure to chemical mixtures and related health impacts

AU - Vinggaard, Anne Marie

AU - Bonefeld-Jørgensen, Eva Cecilie

AU - Jensen, Tina Kold

AU - Fernandez, Mariana F

AU - Rosenmai, Anna Kjerstine

AU - Taxvig, Camilla

AU - Rodriguez-Carrillo, Andrea

AU - Wielsøe, Maria

AU - Long, Manhai

AU - Olea, Nicolas

AU - Antignac, Jean-Philippe

AU - Hamers, Timo

AU - Lamoree, Marja

N1 - Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

PY - 2021/1

Y1 - 2021/1

N2 - Humans are exposed to a large number of chemicals from sources such as the environment, food, and consumer products. There is growing concern that human exposure to chemical mixtures, especially during critical periods of development, increases the risk of adverse health effects in newborns or later in life. Historically, the one-chemical-at-a-time approach has been applied both for exposure assessment and hazard characterisation, leading to insufficient knowledge about human health effects caused by exposure to mixtures of chemicals that have the same target. To circumvent this challenge researchers can apply in vitro assays to analyse both exposure to and human health effects of chemical mixtures in biological samples. The advantages of using in vitro assays are: (i) that an integrated effect is measured, taking combined mixture effects into account and (ii) that in vitro assays can reduce complexity in identification of Chemicals of Emerging Concern (CECs) in human tissues. We have reviewed the state-of-the-art on the use of receptor-based in vitro assays to assess human exposure to chemical mixtures and related health impacts. A total of 43 studies were identified, in which endpoints for the arylhydrocarbon receptor (AhR), the estrogen receptor (ER), and the androgen receptor (AR) were used. The majority of studies reported biological activities that could be associated with breast cancer incidence, male reproductive health effects, developmental toxicities, human demographic characteristics or lifestyle factors such as dietary patterns. A few studies used the bioactivities to check the coverage of the chemical analyses of the human samples, whereas in vitro assays have so far not regularly been used for identifying CECs in human samples, but rather in environmental matrices or food packaging materials. A huge field of novel applications using receptor-based in vitro assays for mixture toxicity assessment on human samples and effect-directed analysis (EDA) using high resolution mass spectrometry (HRMS) for identification of toxic compounds waits for exploration. In the future this could lead to a paradigm shift in the way we unravel adverse human health effects caused by chemical mixtures.

AB - Humans are exposed to a large number of chemicals from sources such as the environment, food, and consumer products. There is growing concern that human exposure to chemical mixtures, especially during critical periods of development, increases the risk of adverse health effects in newborns or later in life. Historically, the one-chemical-at-a-time approach has been applied both for exposure assessment and hazard characterisation, leading to insufficient knowledge about human health effects caused by exposure to mixtures of chemicals that have the same target. To circumvent this challenge researchers can apply in vitro assays to analyse both exposure to and human health effects of chemical mixtures in biological samples. The advantages of using in vitro assays are: (i) that an integrated effect is measured, taking combined mixture effects into account and (ii) that in vitro assays can reduce complexity in identification of Chemicals of Emerging Concern (CECs) in human tissues. We have reviewed the state-of-the-art on the use of receptor-based in vitro assays to assess human exposure to chemical mixtures and related health impacts. A total of 43 studies were identified, in which endpoints for the arylhydrocarbon receptor (AhR), the estrogen receptor (ER), and the androgen receptor (AR) were used. The majority of studies reported biological activities that could be associated with breast cancer incidence, male reproductive health effects, developmental toxicities, human demographic characteristics or lifestyle factors such as dietary patterns. A few studies used the bioactivities to check the coverage of the chemical analyses of the human samples, whereas in vitro assays have so far not regularly been used for identifying CECs in human samples, but rather in environmental matrices or food packaging materials. A huge field of novel applications using receptor-based in vitro assays for mixture toxicity assessment on human samples and effect-directed analysis (EDA) using high resolution mass spectrometry (HRMS) for identification of toxic compounds waits for exploration. In the future this could lead to a paradigm shift in the way we unravel adverse human health effects caused by chemical mixtures.

KW - in vitro assays

KW - biomarker

KW - effect-directed analysis

KW - human diseases

KW - human health

KW - mixtures

U2 - 10.1016/j.envint.2020.106191

DO - 10.1016/j.envint.2020.106191

M3 - Review

C2 - 33068852

VL - 146

JO - Environment International

JF - Environment International

SN - 0160-4120

M1 - 106191

ER -