Recent progress in miRNA biogenesis and decay

Xavier Bofill-De Ros*, Ulf Andersson Vang Ørom*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Abstract

MicroRNAs are a class of small regulatory RNAs that mediate regulation of protein synthesis by recognizing sequence elements in mRNAs. MicroRNAs are processed through a series of steps starting from transcription and primary processing in the nucleus to precursor processing and mature function in the cytoplasm. It is also in the cytoplasm where levels of mature microRNAs can be modulated through decay mechanisms. Here, we review the recent progress in the lifetime of a microRNA at all steps required for maintaining their homoeostasis. The increasing knowledge about microRNA regulation upholds great promise as therapeutic targets.

Original languageEnglish
JournalRNA Biology
Volume21
Issue1
Pages (from-to)1-8
Number of pages8
ISSN1547-6286
DOIs
Publication statusPublished - 2024

Keywords

  • miRNA biogenesis
  • miRNA decay
  • miRNA stability
  • miRNA targeting
  • miRNA therapeutics

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