Recent Advancements in Using Polymers for Intestinal Mucoadhesion and Mucopenetration

Essi Taipaleenmäki, Brigitte Städler*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review


Oral administration of actives is the most desired form of delivery, but the formulations need to overcome a variety of barriers including the intestinal mucus. This feature article summarizes the developments from the past 2–3 years in this context focusing on polymer-based formulations. The progress in assembling mucopenetrating nanoparticles is outlined considering coatings using noninteracting polymers as well as virus-like particles and charge-shifting particles. Next, polymers and their modification to enhance mucoadhesion are discussed, followed by providing examples of double-encapsulation systems that aim to combine mucopenetration with mucoadhesion in the same formulation. Finally, a short outlook is provided highlighting a few of the most pressing challenges to address.

Original languageEnglish
Article number1900342
JournalMacromolecular Bioscience
Number of pages9
Publication statusPublished - 2020


  • mucoadhesion, mucopenetration, nanoparticles, oral administration
  • PEG


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