Abstract
Oral administration of actives is the most desired form of delivery, but the formulations need to overcome a variety of barriers including the intestinal mucus. This feature article summarizes the developments from the past 2–3 years in this context focusing on polymer-based formulations. The progress in assembling mucopenetrating nanoparticles is outlined considering coatings using noninteracting polymers as well as virus-like particles and charge-shifting particles. Next, polymers and their modification to enhance mucoadhesion are discussed, followed by providing examples of double-encapsulation systems that aim to combine mucopenetration with mucoadhesion in the same formulation. Finally, a short outlook is provided highlighting a few of the most pressing challenges to address.
| Original language | English |
|---|---|
| Article number | 1900342 |
| Journal | Macromolecular Bioscience |
| Volume | 20 |
| Issue | 3 |
| Number of pages | 9 |
| ISSN | 1616-5187 |
| DOIs | |
| Publication status | Published - 2020 |
Keywords
- mucoadhesion, mucopenetration, nanoparticles, oral administration
- PEG