Rapid and Efficient Conversion of 11CO2 to 11CO through Silacarboxylic Acids: Applications in Pd-Mediated Carbonylations

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  • Patrik Nordeman, Uppsala Univ, Uppsala University, Dept Med Chem, Platform Preclin PET
  • ,
  • Stig D. Friis
  • ,
  • Thomas L. Andersen
  • ,
  • Helene Audrain
  • Mats Larhed, Uppsala Univ, Uppsala University, BMC, Dept Med Chem, Sci Life Lab
  • ,
  • Troels Skrydstrup
  • Gunnar Antoni, Uppsala Univ, Uppsala University, Dept Med Chem, Platform Preclin PET

Herein, we present a new rapid, efficient, and low-cost radiosynthetic protocol for the conversion of (CO2)-C-11 to (CO)-C-11 and its subsequent application in Pd-mediated reactions of importance for PET applications. This room-temperature methodology, using readily available chemical reagents, is carried out in simple glass vials, thus eliminating the need for expensive and specialized high-temperature equipment to access (CO)-C-11. With this fast and near-quantitative conversion of (CO2)-C-11 into (CO)-C-11, aryl and heteroaryl iodides were easily converted into a broad selection of biologically active amides in radiochemical yields ranging from 29-84 %.

Original languageEnglish
JournalChemistry: A European Journal
Pages (from-to)17601-17604
Number of pages4
Publication statusPublished - 2015

    Research areas

  • carbon monoxide, carbon-11, carbon dioxide fixation, positron emission tomography, radiochemistry, POSITRON-EMISSION-TOMOGRAPHY, ARYL HALIDES, MONOXIDE, PET, COMPLEXES, CHEMISTRY, PRESSURE, KETONES

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ID: 96495338