QUARTET: A SIOP Europe project for quality and excellence in radiotherapy and imaging for children and adolescents with cancer

Sarah M. Kelly*, Rachel Effeney, Mark N. Gaze, Valérie Bernier-Chastagner, Anne Blondeel, Enrico Clementel, Coreen Corning, Karin Dieckmann, Samira Essiaf, Lorenza Gandola, Geert O. Janssens, Pamela R. Kearns, Denis Lacombe, Yasmin Lassen-Ramshad, Hans Merks, Elizabeth Miles, Laetitia Padovani, Giovanni Scarzello, Rudolf Schwarz, Beate TimmermannRick R. van Rijn, Gilles Vassal, Tom Boterberg, Henry C. Mandeville, the QUARTET Project and the SIOPE Radiation Oncology Working Group

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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The European Society for Paediatric Oncology (SIOPE) Radiation Oncology Working Group presents the QUARTET Project: a centralised quality assurance programme designed to standardise care and improve the quality of radiotherapy and imaging for international clinical trials recruiting children and adolescents with cancer throughout Europe. QUARTET combines the paediatric radiation oncology expertise of SIOPE with the infrastructure and experience of the European Organisation for Research and Treatment of Cancer to deliver radiotherapy quality assurance programmes for large, prospective, international clinical trials. QUARTET-affiliated trials include children and adolescents with brain tumours, neuroblastoma, sarcomas including rhabdomyosarcoma, and renal tumours including Wilms’ tumour. With nine prospective clinical trials and two retrospective studies within the active portfolio in March 2022, QUARTET will collect one of the largest repositories of paediatric radiotherapy and imaging data, support the clinical assessment of radiotherapy, and evaluate the role and benefit of radiotherapy quality assurance for this cohort of patients within the context of clinical trials.

Original languageEnglish
JournalEuropean Journal of Cancer
Pages (from-to)209-220
Number of pages12
Publication statusPublished - Sept 2022


  • Clinical trial
  • Oncology
  • Paediatric
  • Quality assurance
  • Radiology
  • Radiotherapy
  • Kidney Neoplasms/drug therapy
  • Prospective Studies
  • Europe
  • Humans
  • Wilms Tumor/drug therapy
  • Adolescent
  • Retrospective Studies
  • Radiation Oncology
  • Child


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