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Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

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  • Morten Leth Jepsen, Denmark
  • Alessio Ottaviani, Department of Biology, University of Rome Tor Vergata, Italy., Denmark
  • Birgitta R. Knudsen
  • Yi-Ping Ho, Denmark
We develop a quantum dot based DNA nanosensor specifically targeting the cleavage–religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy
Original languageEnglish
JournalR S C Advances
Pages (from-to)2491-2494
Number of pages4
Publication statusPublished - 1 Jan 2014

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