Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

Morten Leth Jepsen; Alessio Ottaviani; Birgitta R. Knudsen; Yi-Ping Ho

doi:10.1039/c3ra45557b

Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

Morten Leth Jepsen, Alessio Ottaviani, Birgitta R. Knudsen, Yi-Ping Ho^*

^*Corresponding author for this work

Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

10 Citations (Scopus)

Abstract

We develop a quantum dot based DNA nanosensor specifically targeting the cleavage–religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy

Original language	English
Journal	R S C Advances
Volume	4
Issue	5
Pages (from-to)	2491-2494
Number of pages	4
ISSN	2046-2069
DOIs	https://doi.org/10.1039/c3ra45557b
Publication status	Published - 1 Jan 2014

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title = "Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I",

abstract = "We develop a quantum dot based DNA nanosensor specifically targeting the cleavage–religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy",

author = "Jepsen, {Morten Leth} and Alessio Ottaviani and Knudsen, {Birgitta R.} and Yi-Ping Ho",

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Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I. / Jepsen, Morten Leth; Ottaviani, Alessio; Knudsen, Birgitta R. et al.
In: R S C Advances, Vol. 4, No. 5, 01.01.2014, p. 2491-2494.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

AU - Jepsen, Morten Leth

AU - Ottaviani, Alessio

AU - Knudsen, Birgitta R.

AU - Ho, Yi-Ping

PY - 2014/1/1

Y1 - 2014/1/1

N2 - We develop a quantum dot based DNA nanosensor specifically targeting the cleavage–religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy

AB - We develop a quantum dot based DNA nanosensor specifically targeting the cleavage–religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy

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DO - 10.1039/c3ra45557b

M3 - Journal article

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SP - 2491

EP - 2494

JO - R S C Advances

JF - R S C Advances

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Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

Abstract

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