Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

Morten Leth Jepsen, Alessio Ottaviani, Birgitta R. Knudsen, Yi-Ping Ho*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

1 Citation (Scopus)

Abstract

We develop a quantum dot based DNA nanosensor specifically targeting the cleavage–religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy
Original languageEnglish
JournalR S C Advances
Volume4
Issue5
Pages (from-to)2491-2494
Number of pages4
ISSN2046-2069
DOIs
Publication statusPublished - 1 Jan 2014

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