@article{b78c3044a4d84ae1ae61e163434ee57f,
title = "Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan",
abstract = "Assessing the possible biological effects of exposure to low doses of ionizing radiation (IR) is one of the prime challenges in radiation protection, especially in medical imaging. Today, radiobiological data on cone beam CT (CBCT) related biological effects are scarce. In children and adults, the induction of DNA double strand breaks (DSBs) in buccal mucosa cells and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) and antioxidant capacity in saliva samples after CBCT examination were examined. No DNA DSBs induction was observed in children nor adults. In children only, an increase in 8-oxo-dG levels was observed 30 minutes after CBCT. At the same time an increase in antioxidant capacity was observed in children, whereas a decrease was observed in adults. Our data indicate that children and adults react differently to IR doses associated with CBCT. Fully understanding these differences could lead to an optimal use of CBCT in different age categories as well as improved radiation protection guidelines.",
author = "Niels Belmans and Liese Gilles and Randy Vermeesen and Piroska Virag and Mihaela Hedesiu and Benjamin Salmon and Sarah Baatout and St{\'e}phane Lucas and Ivo Lambrichts and Reinhilde Jacobs and Marjan Moreels and Oenning, {A. C.} and C. Chaussain and C. Lefevre and M. Baciut and M. Marcu and O. Almasan and R. Roman and I. Barbur and C. Dinu and H. Rotaru and L. Hurubeanu and V. Istouan and O. Lucaciu and D. Leucuta and B. Crisan and L. Bogdan and C. Candea and S. Bran and G. Baciut and H. Bosmans and R. Bogaerts and C. Politis and A. Stratis and R. Pauwels and Vasconcelos, {K. de F.} and L. Nicolielo and E. Tijskens and M. Vranckx and A. Ockerman and E. Claerhout and E. Embrechts and {DIMITRA Research Group}",
note = "Funding Information: The authors like to thank all patients (and their parents) for their willingness to contribute to this study. They also like to express their gratitude towards the hospital staff, especially Christelle Lefevre and the CRB facility (Dr. Sarah Tubiana, HUPNVS – APHP, France) for their indispensable help with the sample collection. The DIMITRA project has received funding from the European Atomic Energy Community{\textquoteright}s Seventh Framework Programme FP7/2007–2011 under grant agreement no 604984 (OPERRA: Open Project for the European Radiation Research Area). The DIMITRA Research Group that contributed to this paper consists of N. Belmans, M. Moreels, S. Baatout, B. Salmon, A.C. Oenning, C. Chaussain, C. Lefevre, M. Hedesiu, P. Virag, M. Baciut, M. Marcu, O. Almasan, R. Roman, A. Porumb, C. Dinu, H. Rotaru, C. Ratiu, O. Lucaciu, B. Crisan, S. Bran, G. Baciut, R. Jacobs, H. Bosmans, R. Bogaerts, C. Politis, A. Stratis, R. Pauwels, K. de F. Vasconcelos, L. Nicolielo, G. Zhang, E. Tijskens, M. Vranckx, A. Ockerman, E. Claerhout, E. Embrechts. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s41598-020-58746-5",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}