Quality control of mRNP in the nucleus

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  • Department of Molecular Biology
Formation of functional mRNA-protein particles requires a plethora of nuclear cotranscriptional and posttranscriptional RNA processing and packaging steps. Faithful execution of these events is closely monitored by surveillance systems that prevent nuclear export of, and/or rapidly degrade, faulty transcripts. Parts of this quality control also serve to eliminate a large number of noncoding RNAs produced by RNA polymerase II. Here, we discuss which aberrant features trigger messenger ribonucleoprotein quality control, how the process is executed, and how it is connected to the transcription machinery and the nuclear pore complex.
Original languageEnglish
JournalChromosoma
Volume117
Issue5
Pages (from-to)419-29
Number of pages10
ISSN0009-5915
DOIs
Publication statusPublished - 2008

    Research areas

  • Cell Nucleus, Humans, Nuclear Pore, RNA Polymerase II, RNA Processing, Post-Transcriptional, RNA Splicing, RNA Stability, RNA, Messenger, Ribonucleoproteins, Transcription, Genetic

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