Quality control of mRNP in the nucleus

Manfred Schmid; Torben Heick Jensen

doi:10.1007/s00412-008-0166-4

Quality control of mRNP in the nucleus

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Abstract

Formation of functional mRNA-protein particles requires a plethora of nuclear cotranscriptional and posttranscriptional RNA processing and packaging steps. Faithful execution of these events is closely monitored by surveillance systems that prevent nuclear export of, and/or rapidly degrade, faulty transcripts. Parts of this quality control also serve to eliminate a large number of noncoding RNAs produced by RNA polymerase II. Here, we discuss which aberrant features trigger messenger ribonucleoprotein quality control, how the process is executed, and how it is connected to the transcription machinery and the nuclear pore complex.

Original language	English
Journal	Chromosoma
Volume	117
Issue	5
Pages (from-to)	419-29
Number of pages	10
ISSN	0009-5915
DOIs	https://doi.org/10.1007/s00412-008-0166-4
Publication status	Published - 2008

Keywords

Cell Nucleus
Humans
Nuclear Pore
RNA Polymerase II
RNA Processing, Post-Transcriptional
RNA Splicing
RNA Stability
RNA, Messenger
Ribonucleoproteins
Transcription, Genetic

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10.1007/s00412-008-0166-4

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AU - Jensen, Torben Heick

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AB - Formation of functional mRNA-protein particles requires a plethora of nuclear cotranscriptional and posttranscriptional RNA processing and packaging steps. Faithful execution of these events is closely monitored by surveillance systems that prevent nuclear export of, and/or rapidly degrade, faulty transcripts. Parts of this quality control also serve to eliminate a large number of noncoding RNAs produced by RNA polymerase II. Here, we discuss which aberrant features trigger messenger ribonucleoprotein quality control, how the process is executed, and how it is connected to the transcription machinery and the nuclear pore complex.

KW - Cell Nucleus

KW - Humans

KW - Nuclear Pore

KW - RNA Polymerase II

KW - RNA Processing, Post-Transcriptional

KW - RNA Splicing

KW - RNA Stability

KW - RNA, Messenger

KW - Ribonucleoproteins

KW - Transcription, Genetic

U2 - 10.1007/s00412-008-0166-4

DO - 10.1007/s00412-008-0166-4

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VL - 117

SP - 419

EP - 429

JO - Chromosoma

JF - Chromosoma

IS - 5

ER -

Quality control of mRNP in the nucleus

Abstract

Keywords

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