Proteins and biosurfactants: Structures, functions, and recent applications

Marcos López Hernández; Jan Skov Pedersen; Daniel E. Otzen

doi:10.1016/j.cocis.2023.101746

Proteins and biosurfactants: Structures, functions, and recent applications

Marcos López Hernández, Jan Skov Pedersen, Daniel E. Otzen^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

8 Citations (Scopus)

Abstract

Synergies between surfactants and proteins are found everywhere in everyday life. Beneficial interactions are exploited in fields such as food processing, pharmaceutical production, and laundry, leading to better products and lower energy consumption. Nevertheless, there is still room for improvement regarding sustainability. Here, biosurfactants (BS) are an attractive alternative to petrochemical surfactants. Insights into BS-protein interactions can help replacing traditional surfactants with BS and uncover new opportunities. Here, we review recent work on proteins' interactions with BS, with focus on the self-assembly of protein:BS complexes and BS’ effects on enzymatic activity. Generally, interactions are milder than those with traditional ionic surfactants, leading to modest effects on protein structure and self-assembly, while enzymatic inhibition is generally observed above BS' critical micelle concentration. Mild interactions between proteins and BS show promise in forming functional complexes with proteins, however, further studies are required to understand and minimize the detrimental effects that do occur.

Original language	English
Article number	101746
Journal	Current Opinion in Colloid and Interface Science
Volume	68
ISSN	1359-0294
DOIs	https://doi.org/10.1016/j.cocis.2023.101746
Publication status	Published - Dec 2023

Keywords

Biosurfactants
Enzyme
Interaction
Protein
Surfactants

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title = "Proteins and biosurfactants: Structures, functions, and recent applications",

abstract = "Synergies between surfactants and proteins are found everywhere in everyday life. Beneficial interactions are exploited in fields such as food processing, pharmaceutical production, and laundry, leading to better products and lower energy consumption. Nevertheless, there is still room for improvement regarding sustainability. Here, biosurfactants (BS) are an attractive alternative to petrochemical surfactants. Insights into BS-protein interactions can help replacing traditional surfactants with BS and uncover new opportunities. Here, we review recent work on proteins' interactions with BS, with focus on the self-assembly of protein:BS complexes and BS{\textquoteright} effects on enzymatic activity. Generally, interactions are milder than those with traditional ionic surfactants, leading to modest effects on protein structure and self-assembly, while enzymatic inhibition is generally observed above BS' critical micelle concentration. Mild interactions between proteins and BS show promise in forming functional complexes with proteins, however, further studies are required to understand and minimize the detrimental effects that do occur.",

keywords = "Biosurfactants, Enzyme, Interaction, Protein, Surfactants",

author = "{L{\'o}pez Hern{\'a}ndez}, Marcos and Pedersen, {Jan Skov} and Otzen, {Daniel E.}",

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year = "2023",

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doi = "10.1016/j.cocis.2023.101746",

language = "English",

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T1 - Proteins and biosurfactants

T2 - Structures, functions, and recent applications

AU - López Hernández, Marcos

AU - Pedersen, Jan Skov

AU - Otzen, Daniel E.

PY - 2023/12

Y1 - 2023/12

N2 - Synergies between surfactants and proteins are found everywhere in everyday life. Beneficial interactions are exploited in fields such as food processing, pharmaceutical production, and laundry, leading to better products and lower energy consumption. Nevertheless, there is still room for improvement regarding sustainability. Here, biosurfactants (BS) are an attractive alternative to petrochemical surfactants. Insights into BS-protein interactions can help replacing traditional surfactants with BS and uncover new opportunities. Here, we review recent work on proteins' interactions with BS, with focus on the self-assembly of protein:BS complexes and BS’ effects on enzymatic activity. Generally, interactions are milder than those with traditional ionic surfactants, leading to modest effects on protein structure and self-assembly, while enzymatic inhibition is generally observed above BS' critical micelle concentration. Mild interactions between proteins and BS show promise in forming functional complexes with proteins, however, further studies are required to understand and minimize the detrimental effects that do occur.

AB - Synergies between surfactants and proteins are found everywhere in everyday life. Beneficial interactions are exploited in fields such as food processing, pharmaceutical production, and laundry, leading to better products and lower energy consumption. Nevertheless, there is still room for improvement regarding sustainability. Here, biosurfactants (BS) are an attractive alternative to petrochemical surfactants. Insights into BS-protein interactions can help replacing traditional surfactants with BS and uncover new opportunities. Here, we review recent work on proteins' interactions with BS, with focus on the self-assembly of protein:BS complexes and BS’ effects on enzymatic activity. Generally, interactions are milder than those with traditional ionic surfactants, leading to modest effects on protein structure and self-assembly, while enzymatic inhibition is generally observed above BS' critical micelle concentration. Mild interactions between proteins and BS show promise in forming functional complexes with proteins, however, further studies are required to understand and minimize the detrimental effects that do occur.

KW - Biosurfactants

KW - Enzyme

KW - Interaction

KW - Protein

KW - Surfactants

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DO - 10.1016/j.cocis.2023.101746

M3 - Review

AN - SCOPUS:85176104763

SN - 1359-0294

VL - 68

JO - Current Opinion in Colloid and Interface Science

JF - Current Opinion in Colloid and Interface Science

M1 - 101746

ER -

Proteins and biosurfactants: Structures, functions, and recent applications

Abstract

Keywords

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