Protein Surface and Core Dynamics Show Concerted Hydration-Dependent Activation

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  • Kathleen Wood
  • ,
  • François-Xavier Gallat
  • ,
  • Renee Otten
  • ,
  • Auke J van Heel
  • ,
  • Mathilde Lethier
  • ,
  • Lambert van Eijck
  • ,
  • Martine Moulin
  • ,
  • Michael Haertlein
  • ,
  • Martin Weik
  • ,
  • Frans A.A. Mulder
By specifically labeling leucine/valine methyl groups and lysine side chains "inside" and "outside" dynamics of proteins on the nanosecond timescale are compared using neutron scattering. Surprisingly, both groups display similar dynamics as a function of temperature, and the buried hydrophobic core is sensitive to hydration and undergoes a dynamical transition.
Original languageEnglish
JournalAngewandte Chemie International Edition
Volume52
Issue2
Pages (from-to)665-668
Number of pages4
ISSN1433-7851
DOIs
Publication statusPublished - 2013

    Research areas

  • NMR neutron scattering protein dynamics

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