Proteasomal oscillation during mild heat shock in aging human skin fibroblasts

David Christian Kraft; Custer C Deocaris; Suresh I S Rattan

doi:10.1196/annals.1354.028

Proteasomal oscillation during mild heat shock in aging human skin fibroblasts

David Christian Kraft, Custer C Deocaris, Suresh I S Rattan

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

28 Citations (Scopus)

Abstract

Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat-stressed human fibroblasts (41 degrees C, 1 h) display an adaptation response pattern in proteasome activity. Remarkably, such response appears to be diverse in severely heat-stressed or senescent fibroblasts. This proteasomal oscillation, as an innate cellular reaction to heat and aging, however, is independent of 20S proteasome protein levels and nuclear factor-E2-related factor 2 (Nrf2) transactivation.

Original language	English
Journal	New York Academy of Sciences. Annals
Volume	1067
Pages (from-to)	224-7
Number of pages	3
ISSN	0077-8923
DOIs	https://doi.org/10.1196/annals.1354.028
Publication status	Published - 2006

Keywords

Adult
Cell Aging
Cells, Cultured
Female
Fibroblasts
Heat-Shock Response
Humans
Proteasome Endopeptidase Complex
Skin Aging
Time Factors

Access to Document

10.1196/annals.1354.028

Cite this

@article{b550c120b28011dea554000ea68e967b,

title = "Proteasomal oscillation during mild heat shock in aging human skin fibroblasts",

abstract = "Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat-stressed human fibroblasts (41 degrees C, 1 h) display an adaptation response pattern in proteasome activity. Remarkably, such response appears to be diverse in severely heat-stressed or senescent fibroblasts. This proteasomal oscillation, as an innate cellular reaction to heat and aging, however, is independent of 20S proteasome protein levels and nuclear factor-E2-related factor 2 (Nrf2) transactivation.",

keywords = "Adult, Cell Aging, Cells, Cultured, Female, Fibroblasts, Heat-Shock Response, Humans, Proteasome Endopeptidase Complex, Skin Aging, Time Factors",

author = "Kraft, {David Christian} and Deocaris, {Custer C} and Rattan, {Suresh I S}",

year = "2006",

doi = "10.1196/annals.1354.028",

language = "English",

volume = "1067",

pages = "224--7",

journal = "New York Academy of Sciences. Annals",

issn = "0077-8923",

publisher = "John Wiley & Sons Inc.",

}

TY - JOUR

T1 - Proteasomal oscillation during mild heat shock in aging human skin fibroblasts

AU - Kraft, David Christian

AU - Deocaris, Custer C

AU - Rattan, Suresh I S

PY - 2006

Y1 - 2006

N2 - Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat-stressed human fibroblasts (41 degrees C, 1 h) display an adaptation response pattern in proteasome activity. Remarkably, such response appears to be diverse in severely heat-stressed or senescent fibroblasts. This proteasomal oscillation, as an innate cellular reaction to heat and aging, however, is independent of 20S proteasome protein levels and nuclear factor-E2-related factor 2 (Nrf2) transactivation.

AB - Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat-stressed human fibroblasts (41 degrees C, 1 h) display an adaptation response pattern in proteasome activity. Remarkably, such response appears to be diverse in severely heat-stressed or senescent fibroblasts. This proteasomal oscillation, as an innate cellular reaction to heat and aging, however, is independent of 20S proteasome protein levels and nuclear factor-E2-related factor 2 (Nrf2) transactivation.

KW - Adult

KW - Cell Aging

KW - Cells, Cultured

KW - Female

KW - Fibroblasts

KW - Heat-Shock Response

KW - Humans

KW - Proteasome Endopeptidase Complex

KW - Skin Aging

KW - Time Factors

U2 - 10.1196/annals.1354.028

DO - 10.1196/annals.1354.028

M3 - Journal article

C2 - 16803990

SN - 0077-8923

VL - 1067

SP - 224

EP - 227

JO - New York Academy of Sciences. Annals

JF - New York Academy of Sciences. Annals

ER -

Proteasomal oscillation during mild heat shock in aging human skin fibroblasts

Abstract

Keywords

Access to Document

Fingerprint

Cite this