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Proposal for the delineation of neoadjuvant target volumes in oesophageal cancer

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Proposal for the delineation of neoadjuvant target volumes in oesophageal cancer. / Thomas, Melissa; Mortensen, Hanna R.; Hoffmann, Lone; Møller, Ditte S.; Troost, Esther G.C.; Muijs, Christina T.; Berbee, Maaike; Bütof, Rebecca; Nicholas, Owen; Radhakrishna, Ganesh; Defraene, Gilles; Nafteux, Philippe; Nordsmark, Marianne; Haustermans, Karin.

In: Radiotherapy and Oncology, Vol. 156, 03.2021, p. 102-112.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Thomas, M, Mortensen, HR, Hoffmann, L, Møller, DS, Troost, EGC, Muijs, CT, Berbee, M, Bütof, R, Nicholas, O, Radhakrishna, G, Defraene, G, Nafteux, P, Nordsmark, M & Haustermans, K 2021, 'Proposal for the delineation of neoadjuvant target volumes in oesophageal cancer', Radiotherapy and Oncology, vol. 156, pp. 102-112. https://doi.org/10.1016/j.radonc.2020.11.032

APA

Thomas, M., Mortensen, H. R., Hoffmann, L., Møller, D. S., Troost, E. G. C., Muijs, C. T., Berbee, M., Bütof, R., Nicholas, O., Radhakrishna, G., Defraene, G., Nafteux, P., Nordsmark, M., & Haustermans, K. (2021). Proposal for the delineation of neoadjuvant target volumes in oesophageal cancer. Radiotherapy and Oncology, 156, 102-112. https://doi.org/10.1016/j.radonc.2020.11.032

CBE

Thomas M, Mortensen HR, Hoffmann L, Møller DS, Troost EGC, Muijs CT, Berbee M, Bütof R, Nicholas O, Radhakrishna G, Defraene G, Nafteux P, Nordsmark M, Haustermans K. 2021. Proposal for the delineation of neoadjuvant target volumes in oesophageal cancer. Radiotherapy and Oncology. 156:102-112. https://doi.org/10.1016/j.radonc.2020.11.032

MLA

Vancouver

Author

Thomas, Melissa ; Mortensen, Hanna R. ; Hoffmann, Lone ; Møller, Ditte S. ; Troost, Esther G.C. ; Muijs, Christina T. ; Berbee, Maaike ; Bütof, Rebecca ; Nicholas, Owen ; Radhakrishna, Ganesh ; Defraene, Gilles ; Nafteux, Philippe ; Nordsmark, Marianne ; Haustermans, Karin. / Proposal for the delineation of neoadjuvant target volumes in oesophageal cancer. In: Radiotherapy and Oncology. 2021 ; Vol. 156. pp. 102-112.

Bibtex

@article{5f4099eca48d45109f201d8ab1ac1782,
title = "Proposal for the delineation of neoadjuvant target volumes in oesophageal cancer",
abstract = "Purpose: To define instructions for delineation of target volumes in the neoadjuvant setting in oesophageal cancer. Materials and methods: Radiation oncologists of five European centres participated in the following consensus process: [1] revision of published (MEDLINE) and national/institutional delineation guidelines; [2] first delineation round of five cases (patient 1–5) according to national/institutional guidelines; [3] consensus meeting to discuss the results of step 1 and 2, followed by a target volume delineation proposal; [4] circulation of proposed instructions for target volume delineation and atlas for feedback; [5] second delineation round of five new cases (patient 6–10) to peer review and validate (two additional centres) the agreed delineation guidelines and atlas; [6] final consensus on the delineation guidelines depicted in an atlas. Target volumes of the delineation rounds were compared between centres by Dice similarity coefficient (DSC) and maximum/mean undirected Hausdorff distances (Hmax/Hmean). Results: In the first delineation round, the consistency between centres was moderate (CTVtotal: DSC = 0.59–0.88; Hmean = 0.2–0.4 cm). Delineations in the second round were much more consistent. Lowest variability was obtained between centres participating in the consensus meeting (CTVtotal: DSC: p < 0.050 between rounds for patients 6/7/8/10; Hmean: p < 0.050 for patients 7/8/10), compared to validation centres (CTVtotal: DSC: p < 0.050 between validation and consensus meeting centres for patients 6/7/8; Hmean: p < 0.050 for patients 7/10). A proposal for delineation of target volumes and an atlas were generated. Conclusion: We proposed instructions for target volume delineation and an atlas for the neoadjuvant radiation treatment in oesophageal cancer. These will enable a more uniform delineation of patients in clinical practice and clinical trials.",
keywords = "Consensus, Delineation atlas, Neoadjuvant chemoradiation, Oesophageal cancer, Proposal for delineation",
author = "Melissa Thomas and Mortensen, {Hanna R.} and Lone Hoffmann and M{\o}ller, {Ditte S.} and Troost, {Esther G.C.} and Muijs, {Christina T.} and Maaike Berbee and Rebecca B{\"u}tof and Owen Nicholas and Ganesh Radhakrishna and Gilles Defraene and Philippe Nafteux and Marianne Nordsmark and Karin Haustermans",
year = "2021",
month = mar,
doi = "10.1016/j.radonc.2020.11.032",
language = "English",
volume = "156",
pages = "102--112",
journal = "Radiotherapy & Oncology",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd.",

}

RIS

TY - JOUR

T1 - Proposal for the delineation of neoadjuvant target volumes in oesophageal cancer

AU - Thomas, Melissa

AU - Mortensen, Hanna R.

AU - Hoffmann, Lone

AU - Møller, Ditte S.

AU - Troost, Esther G.C.

AU - Muijs, Christina T.

AU - Berbee, Maaike

AU - Bütof, Rebecca

AU - Nicholas, Owen

AU - Radhakrishna, Ganesh

AU - Defraene, Gilles

AU - Nafteux, Philippe

AU - Nordsmark, Marianne

AU - Haustermans, Karin

PY - 2021/3

Y1 - 2021/3

N2 - Purpose: To define instructions for delineation of target volumes in the neoadjuvant setting in oesophageal cancer. Materials and methods: Radiation oncologists of five European centres participated in the following consensus process: [1] revision of published (MEDLINE) and national/institutional delineation guidelines; [2] first delineation round of five cases (patient 1–5) according to national/institutional guidelines; [3] consensus meeting to discuss the results of step 1 and 2, followed by a target volume delineation proposal; [4] circulation of proposed instructions for target volume delineation and atlas for feedback; [5] second delineation round of five new cases (patient 6–10) to peer review and validate (two additional centres) the agreed delineation guidelines and atlas; [6] final consensus on the delineation guidelines depicted in an atlas. Target volumes of the delineation rounds were compared between centres by Dice similarity coefficient (DSC) and maximum/mean undirected Hausdorff distances (Hmax/Hmean). Results: In the first delineation round, the consistency between centres was moderate (CTVtotal: DSC = 0.59–0.88; Hmean = 0.2–0.4 cm). Delineations in the second round were much more consistent. Lowest variability was obtained between centres participating in the consensus meeting (CTVtotal: DSC: p < 0.050 between rounds for patients 6/7/8/10; Hmean: p < 0.050 for patients 7/8/10), compared to validation centres (CTVtotal: DSC: p < 0.050 between validation and consensus meeting centres for patients 6/7/8; Hmean: p < 0.050 for patients 7/10). A proposal for delineation of target volumes and an atlas were generated. Conclusion: We proposed instructions for target volume delineation and an atlas for the neoadjuvant radiation treatment in oesophageal cancer. These will enable a more uniform delineation of patients in clinical practice and clinical trials.

AB - Purpose: To define instructions for delineation of target volumes in the neoadjuvant setting in oesophageal cancer. Materials and methods: Radiation oncologists of five European centres participated in the following consensus process: [1] revision of published (MEDLINE) and national/institutional delineation guidelines; [2] first delineation round of five cases (patient 1–5) according to national/institutional guidelines; [3] consensus meeting to discuss the results of step 1 and 2, followed by a target volume delineation proposal; [4] circulation of proposed instructions for target volume delineation and atlas for feedback; [5] second delineation round of five new cases (patient 6–10) to peer review and validate (two additional centres) the agreed delineation guidelines and atlas; [6] final consensus on the delineation guidelines depicted in an atlas. Target volumes of the delineation rounds were compared between centres by Dice similarity coefficient (DSC) and maximum/mean undirected Hausdorff distances (Hmax/Hmean). Results: In the first delineation round, the consistency between centres was moderate (CTVtotal: DSC = 0.59–0.88; Hmean = 0.2–0.4 cm). Delineations in the second round were much more consistent. Lowest variability was obtained between centres participating in the consensus meeting (CTVtotal: DSC: p < 0.050 between rounds for patients 6/7/8/10; Hmean: p < 0.050 for patients 7/8/10), compared to validation centres (CTVtotal: DSC: p < 0.050 between validation and consensus meeting centres for patients 6/7/8; Hmean: p < 0.050 for patients 7/10). A proposal for delineation of target volumes and an atlas were generated. Conclusion: We proposed instructions for target volume delineation and an atlas for the neoadjuvant radiation treatment in oesophageal cancer. These will enable a more uniform delineation of patients in clinical practice and clinical trials.

KW - Consensus

KW - Delineation atlas

KW - Neoadjuvant chemoradiation

KW - Oesophageal cancer

KW - Proposal for delineation

UR - http://www.scopus.com/inward/record.url?scp=85098482511&partnerID=8YFLogxK

U2 - 10.1016/j.radonc.2020.11.032

DO - 10.1016/j.radonc.2020.11.032

M3 - Journal article

C2 - 33285194

AN - SCOPUS:85098482511

VL - 156

SP - 102

EP - 112

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

SN - 0167-8140

ER -