Prolonged loss of force and power following fatiguing contractions in rat soleus muscles. Is low-frequency fatigue an issue during dynamic contractions?

Jon Herskind*, Anders Meldgaard Kristensen, Niels Ørtenblad, Frank de Paoli, Kristian Vissing, Kristian Overgaard

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Low-frequency fatigue (LFF) is defined by a relatively larger deficit in isometric force elicited by low-frequency electrical stimulation compared with high-frequency stimulation. However, the effects of LFF on power during dynamic contractions elicited at low and high frequencies have not been thoroughly characterized. In the current study, rat soleus muscles underwent fatiguing either concentric, eccentric, or isometric contractions. Before and 1 h after the fatiguing contractions, a series of brief isometric and dynamic contractions elicited at 20 and 80 Hz stimulation to establish force-velocity relationships. Maximal force (F max), velocity (V max), and power (P max) were assessed for each frequency. Sarcoplasmic reticulum (SR) Ca 2 + release and reuptake rates were assessed pre- and postfatigue. Prolonged fatigue was observed as a loss of F max and P max in muscles fatigued by concentric or eccentric, but not by isometric contractions. When quantified as a decrease in the ratio between 20 Hz and 80 Hz contractile output, LFF was more pronounced for isometric force than for power (-21% vs. -16% for concentrically fatigued muscles, P = 0.003; 29 vs. 13% for eccentrically fatigued muscles, P < 0.001). No changes in SR Ca 2 + release or reuptake rates were observed. We conclude that LFF is less pronounced when expressed in terms of power deficits than when expressed in terms of force deficits, and that LFF, therefore, likely affects performance to a lesser degree during fast concentric contractions than during static or slow contractions.

Original languageEnglish
JournalAmerican journal of physiology. Cell physiology
Volume323
Issue6
Pages (from-to)C1642-C1651
Number of pages10
ISSN0363-6143
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Ca2+ release
  • dynamic muscle contractions
  • excitation-contraction coupling
  • force-velocity relationship
  • prolonged low-frequency force depression

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