Progression of sleep disturbances in Parkinson's disease: a 5-year longitudinal study

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  • Zheyu Xu, Newcastle Univ, Newcastle University - UK, Translat & Clin Res Inst
  • ,
  • Kirstie N. Anderson, Newcastle Univ, Newcastle University - UK, Translat & Clin Res Inst
  • ,
  • Seyed Ehsan Saffari, Duke Natl Univ Singapore, National University of Singapore, Ctr Quantitat Med, Med Sch
  • ,
  • Rachael A. Lawson, Newcastle Univ, Newcastle University - UK, Translat & Clin Res Inst
  • ,
  • K. Ray Chaudhuri, Kings Coll London, University of London, King's College London, Inst Psychiat Psychol & Neurosci
  • ,
  • David Brooks
  • Nicola Pavese

Background Sleep disorders can occur in early Parkinson's disease (PD). However, the relationship between different sleep disturbances and their longitudinal evolution has not been fully explored. Objective To describe the frequency, coexistence, and longitudinal change in excessive daytime sleepiness (EDS), insomnia, and probable REM sleep behavior disorder (pRBD) in early PD. Methods Data were obtained from the Parkinson's Progression Markers Initiative (PPMI). EDS, insomnia, and pRBD were defined using the Epworth Sleepiness Scale, MDS-UPDRS Part I sub-item 1.7, and RBD screening questionnaire. Results 218 PD subjects and 102 controls completed 5 years of follow-up. At baseline, 69 (31.7%) PD subjects reported one type of sleep disturbance, 25 (11.5%) reported two types of sleep disturbances, and three (1.4%) reported all three types of sleep disturbances. At 5 years, the number of PD subjects reporting one, two, and three types of sleep disturbances was 85 (39.0%), 51 (23.4%), and 16 (7.3%), respectively. Only 41(18.8%) patients were taking sleep medications. The largest increase in frequency was seen in insomnia (44.5%), followed by EDS (32.1%) and pRBD (31.2%). Insomnia was the most common sleep problem at any time over the 5-year follow-up. The frequency of sleep disturbances in HCs remained stable. Conclusions There is a progressive increase in the frequency of sleep disturbances in PD, with the number of subjects reporting multiple sleep disturbances increasing over time. Relatively a few patients reported multiple sleep disturbances, suggesting that they can have different pathogenesis. A large number of patients were not treated for their sleep disturbances.

Original languageEnglish
Book seriesJournal of Neurology
Volume268
Issue1
Pages (from-to)312-320
Number of pages9
ISSN0340-5354
DOIs
Publication statusPublished - Jan 2021

    Research areas

  • Parkinson's disease, Sleep, Insomnia, RBD, EDS, PPMI, EXCESSIVE DAYTIME SLEEPINESS, DISORDER SCREENING QUESTIONNAIRE, QUALITY-OF-LIFE, BEHAVIOR DISORDER, NONMOTOR SYMPTOMS, EARLY-STAGE, INSOMNIA, DYSFUNCTION, PREVALENCE, EVOLUTION

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