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Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression

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Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression. / Tillmann, Sandra; Awwad, Hussain M; Eskelund, Amanda R; Treccani, Giulia; Geisel, Juergen; Wegener, Gregers; Obeid, Rima.

In: Molecular Nutrition & Food Research, Vol. 62, No. 7, 1701070, 2018, p. e1701070.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Tillmann, S, Awwad, HM, Eskelund, AR, Treccani, G, Geisel, J, Wegener, G & Obeid, R 2018, 'Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression', Molecular Nutrition & Food Research, vol. 62, no. 7, 1701070, pp. e1701070. <https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.201701070>

APA

CBE

Tillmann S, Awwad HM, Eskelund AR, Treccani G, Geisel J, Wegener G, Obeid R. 2018. Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression. Molecular Nutrition & Food Research. 62(7):e1701070.

MLA

Tillmann, Sandra et al. "Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression". Molecular Nutrition & Food Research. 2018, 62(7). e1701070.

Vancouver

Tillmann S, Awwad HM, Eskelund AR, Treccani G, Geisel J, Wegener G et al. Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression. Molecular Nutrition & Food Research. 2018;62(7):e1701070. 1701070.

Author

Tillmann, Sandra ; Awwad, Hussain M ; Eskelund, Amanda R ; Treccani, Giulia ; Geisel, Juergen ; Wegener, Gregers ; Obeid, Rima. / Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression. In: Molecular Nutrition & Food Research. 2018 ; Vol. 62, No. 7. pp. e1701070.

Bibtex

@article{72e71e5285484d7391e218c35803a45e,
title = "Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression",
abstract = "SCOPE: Probiotics may influence one-carbon (C1) metabolism, neurotransmitters, liver function markers, or behavior.METHODS AND RESULTS: Male adult Flinders Sensitive Line rats (model of depression, FSL; n = 22) received Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 (109or 1010colony-forming units/d) or vehicle for 10 weeks. The controls, Flinders Resistant Line rats (FRL, n = 8), only received vehicle. C1-related metabolites were measured in plasma, urine, and different tissues. Monoamine concentrations were measured in plasma, hippocampus, and prefrontal cortex. Vehicle-treated FSL rats had higher plasma concentrations of betaine, choline, and dimethylglycine, but lower plasma homocysteine and liver S-adenosylmethionine (SAM) than FRLs. FSL rats receiving high-dose probiotics had lower plasma betaine and higher liver SAM compared to vehicle-treated FSL rats. FSLs had higher concentrations of norepinephrine, dopamine, and serotonin than FRLs across various brain regions. Probiotics decreased plasma dopamine in FSLs in a dose-dependent manner. There were no detectable changes in liver function markers or behavior.CONCLUSIONS: Probiotics reduced the flow of methyl groups via betaine, increased liver SAM, and decreased plasma dopamine and norepinephrine. Since these changes in methylation and catecholamine pathways are known to be involved in several diseases, future investigation of the effect of probiotics is warranted. This article is protected by copyright. All rights reserved.",
keywords = "depression, dopamine, gut–brain axis, probiotics, S-adenosylmethionine, Lactobacillus helveticus/growth & development, Probiotics/administration & dosage, Dopamine/blood, Prefrontal Cortex/metabolism, Male, Behavior, Animal, Dopamine Antagonists/administration & dosage, Norepinephrine/antagonists & inhibitors, S-Adenosylmethionine/antagonists & inhibitors, Rats, Mutant Strains, Liver/metabolism, Antidepressive Agents/administration & dosage, Biomarkers/blood, Depression/blood, Freeze Drying, Homocysteine/antagonists & inhibitors, Random Allocation, Animals, Neurons/metabolism, Bifidobacterium longum/growth & development, Hippocampus/metabolism, Methylation",
author = "Sandra Tillmann and Awwad, {Hussain M} and Eskelund, {Amanda R} and Giulia Treccani and Juergen Geisel and Gregers Wegener and Rima Obeid",
note = "This article is protected by copyright. All rights reserved.",
year = "2018",
language = "English",
volume = "62",
pages = "e1701070",
journal = "Molecular Nutrition & Food Research",
issn = "1613-4125",
publisher = "Wiley-VCH Verlag",
number = "7",

}

RIS

TY - JOUR

T1 - Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression

AU - Tillmann, Sandra

AU - Awwad, Hussain M

AU - Eskelund, Amanda R

AU - Treccani, Giulia

AU - Geisel, Juergen

AU - Wegener, Gregers

AU - Obeid, Rima

N1 - This article is protected by copyright. All rights reserved.

PY - 2018

Y1 - 2018

N2 - SCOPE: Probiotics may influence one-carbon (C1) metabolism, neurotransmitters, liver function markers, or behavior.METHODS AND RESULTS: Male adult Flinders Sensitive Line rats (model of depression, FSL; n = 22) received Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 (109or 1010colony-forming units/d) or vehicle for 10 weeks. The controls, Flinders Resistant Line rats (FRL, n = 8), only received vehicle. C1-related metabolites were measured in plasma, urine, and different tissues. Monoamine concentrations were measured in plasma, hippocampus, and prefrontal cortex. Vehicle-treated FSL rats had higher plasma concentrations of betaine, choline, and dimethylglycine, but lower plasma homocysteine and liver S-adenosylmethionine (SAM) than FRLs. FSL rats receiving high-dose probiotics had lower plasma betaine and higher liver SAM compared to vehicle-treated FSL rats. FSLs had higher concentrations of norepinephrine, dopamine, and serotonin than FRLs across various brain regions. Probiotics decreased plasma dopamine in FSLs in a dose-dependent manner. There were no detectable changes in liver function markers or behavior.CONCLUSIONS: Probiotics reduced the flow of methyl groups via betaine, increased liver SAM, and decreased plasma dopamine and norepinephrine. Since these changes in methylation and catecholamine pathways are known to be involved in several diseases, future investigation of the effect of probiotics is warranted. This article is protected by copyright. All rights reserved.

AB - SCOPE: Probiotics may influence one-carbon (C1) metabolism, neurotransmitters, liver function markers, or behavior.METHODS AND RESULTS: Male adult Flinders Sensitive Line rats (model of depression, FSL; n = 22) received Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 (109or 1010colony-forming units/d) or vehicle for 10 weeks. The controls, Flinders Resistant Line rats (FRL, n = 8), only received vehicle. C1-related metabolites were measured in plasma, urine, and different tissues. Monoamine concentrations were measured in plasma, hippocampus, and prefrontal cortex. Vehicle-treated FSL rats had higher plasma concentrations of betaine, choline, and dimethylglycine, but lower plasma homocysteine and liver S-adenosylmethionine (SAM) than FRLs. FSL rats receiving high-dose probiotics had lower plasma betaine and higher liver SAM compared to vehicle-treated FSL rats. FSLs had higher concentrations of norepinephrine, dopamine, and serotonin than FRLs across various brain regions. Probiotics decreased plasma dopamine in FSLs in a dose-dependent manner. There were no detectable changes in liver function markers or behavior.CONCLUSIONS: Probiotics reduced the flow of methyl groups via betaine, increased liver SAM, and decreased plasma dopamine and norepinephrine. Since these changes in methylation and catecholamine pathways are known to be involved in several diseases, future investigation of the effect of probiotics is warranted. This article is protected by copyright. All rights reserved.

KW - depression

KW - dopamine

KW - gut–brain axis

KW - probiotics

KW - S-adenosylmethionine

KW - Lactobacillus helveticus/growth & development

KW - Probiotics/administration & dosage

KW - Dopamine/blood

KW - Prefrontal Cortex/metabolism

KW - Male

KW - Behavior, Animal

KW - Dopamine Antagonists/administration & dosage

KW - Norepinephrine/antagonists & inhibitors

KW - S-Adenosylmethionine/antagonists & inhibitors

KW - Rats, Mutant Strains

KW - Liver/metabolism

KW - Antidepressive Agents/administration & dosage

KW - Biomarkers/blood

KW - Depression/blood

KW - Freeze Drying

KW - Homocysteine/antagonists & inhibitors

KW - Random Allocation

KW - Animals

KW - Neurons/metabolism

KW - Bifidobacterium longum/growth & development

KW - Hippocampus/metabolism

KW - Methylation

UR - http://www.scopus.com/inward/record.url?scp=85043575409&partnerID=8YFLogxK

M3 - Journal article

C2 - 29453804

VL - 62

SP - e1701070

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

SN - 1613-4125

IS - 7

M1 - 1701070

ER -