Prevalence of Diarylprolinol Silyl Ethers as Catalysts in Total Synthesis and Patents

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Diarylprolinol silyl ethers are among the most utilized stereoselective organocatalysts for the construction of complex molecules. With their debut in 2005, these catalysts have been applied in numerous method developments primarily leveraging enamine and iminium-ion catalysis. These strategies have extended into the preparation of complex molecules in both academic and industrial settings. This Review intends to give an overview of the application of the diarylprolinol silyl ether catalysts in total synthesis. Furthermore, integration of these catalysts in patent literature is also disclosed highlighting the versatility of the catalytic system.

Original languageEnglish
JournalChemical Reviews
Pages (from-to)4221-4260
Number of pages40
Publication statusPublished - 2019

See relations at Aarhus University Citationformats

ID: 149726764