Prevalence and predictors of severe hypoglycemia in Danish children and adolescents with diabetes

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Prevalence and predictors of severe hypoglycemia in Danish children and adolescents with diabetes. / Johansen, A; Kanijo, B; Fredheim, S; Olsen, B; Hertz, B; Lauridsen, M H; Andersen, Mlm; Mortensen, Hb; Svensson, J; the Danish Society for Diabetes in Childhood.

In: Pediatric Diabetes, Vol. 16, No. 5, 2015, p. 354-360.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Johansen, A, Kanijo, B, Fredheim, S, Olsen, B, Hertz, B, Lauridsen, MH, Andersen, M, Mortensen, H, Svensson, J & the Danish Society for Diabetes in Childhood 2015, 'Prevalence and predictors of severe hypoglycemia in Danish children and adolescents with diabetes', Pediatric Diabetes, vol. 16, no. 5, pp. 354-360. https://doi.org/10.1111/pedi.12171

APA

Johansen, A., Kanijo, B., Fredheim, S., Olsen, B., Hertz, B., Lauridsen, M. H., Andersen, M., Mortensen, H., Svensson, J., & the Danish Society for Diabetes in Childhood (2015). Prevalence and predictors of severe hypoglycemia in Danish children and adolescents with diabetes. Pediatric Diabetes, 16(5), 354-360. https://doi.org/10.1111/pedi.12171

CBE

Johansen A, Kanijo B, Fredheim S, Olsen B, Hertz B, Lauridsen MH, Andersen M, Mortensen H, Svensson J, the Danish Society for Diabetes in Childhood. 2015. Prevalence and predictors of severe hypoglycemia in Danish children and adolescents with diabetes. Pediatric Diabetes. 16(5):354-360. https://doi.org/10.1111/pedi.12171

MLA

Vancouver

Author

Johansen, A ; Kanijo, B ; Fredheim, S ; Olsen, B ; Hertz, B ; Lauridsen, M H ; Andersen, Mlm ; Mortensen, Hb ; Svensson, J ; the Danish Society for Diabetes in Childhood. / Prevalence and predictors of severe hypoglycemia in Danish children and adolescents with diabetes. In: Pediatric Diabetes. 2015 ; Vol. 16, No. 5. pp. 354-360.

Bibtex

@article{5dce7b00937343e8a527c4c72984b73f,
title = "Prevalence and predictors of severe hypoglycemia in Danish children and adolescents with diabetes",
abstract = "OBJECTIVE: To investigate the prevalence of severe hypoglycemia in Danish children and adolescents with type 1 diabetes and to pinpoint predictors of this acute complication in children on modern treatment modalities.RESEARCH DESIGN AND METHODS: The study is based on data from DanDiabKids, a national diabetes register for children and adolescents. The register contains data on patients with type 1 diabetes with an ascertainment rate of 99%. Data from 3320 patients aged 0-18 yr was included in the study period from 1998 to 2009 and analyzed using a negative binomial model.RESULTS: One thousand nine hundred and ninety-nine episodes of severe hypoglycemia in 867 patients were registered conferring an overall incidence of severe hypoglycemia of 15.1 [95% confident interval (CI): 13.8; 16.4] per 100 patient years. This remained unchanged during the study period. Duration of diabetes, age and treatment in centers managing less than 100 patients significantly increased the risk of severe hypoglycemia (p < 0.001). Patients on insulin pump therapy had a 42% reduced risk of severe hypoglycemia compared with pen treated patients (p = 0.01). Patients treated with five or more daily insulin injections had a 31% (95% CI: 17; 49) reduced risk of severe hypoglycemia compared to patients on fewer daily injections (p = 0.015).CONCLUSIONS: Despite improvements in metabolic control over a decade the prevalence of severe hypoglycemic events remained unchanged. More intensive treatments such as insulin pump therapy and multiple daily injections on a national level seems to be a protective factor for developing severe hypoglycemia up to 2009.",
author = "A Johansen and B Kanijo and S Fredheim and B Olsen and B Hertz and Lauridsen, {M H} and Mlm Andersen and Hb Mortensen and J Svensson and {the Danish Society for Diabetes in Childhood}",
note = "{\textcopyright} 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2015",
doi = "10.1111/pedi.12171",
language = "English",
volume = "16",
pages = "354--360",
journal = "Pediatric Diabetes",
issn = "1399-543X",
publisher = "Wiley-Blackwell Munksgaard",
number = "5",

}

RIS

TY - JOUR

T1 - Prevalence and predictors of severe hypoglycemia in Danish children and adolescents with diabetes

AU - Johansen, A

AU - Kanijo, B

AU - Fredheim, S

AU - Olsen, B

AU - Hertz, B

AU - Lauridsen, M H

AU - Andersen, Mlm

AU - Mortensen, Hb

AU - Svensson, J

AU - the Danish Society for Diabetes in Childhood

N1 - © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2015

Y1 - 2015

N2 - OBJECTIVE: To investigate the prevalence of severe hypoglycemia in Danish children and adolescents with type 1 diabetes and to pinpoint predictors of this acute complication in children on modern treatment modalities.RESEARCH DESIGN AND METHODS: The study is based on data from DanDiabKids, a national diabetes register for children and adolescents. The register contains data on patients with type 1 diabetes with an ascertainment rate of 99%. Data from 3320 patients aged 0-18 yr was included in the study period from 1998 to 2009 and analyzed using a negative binomial model.RESULTS: One thousand nine hundred and ninety-nine episodes of severe hypoglycemia in 867 patients were registered conferring an overall incidence of severe hypoglycemia of 15.1 [95% confident interval (CI): 13.8; 16.4] per 100 patient years. This remained unchanged during the study period. Duration of diabetes, age and treatment in centers managing less than 100 patients significantly increased the risk of severe hypoglycemia (p < 0.001). Patients on insulin pump therapy had a 42% reduced risk of severe hypoglycemia compared with pen treated patients (p = 0.01). Patients treated with five or more daily insulin injections had a 31% (95% CI: 17; 49) reduced risk of severe hypoglycemia compared to patients on fewer daily injections (p = 0.015).CONCLUSIONS: Despite improvements in metabolic control over a decade the prevalence of severe hypoglycemic events remained unchanged. More intensive treatments such as insulin pump therapy and multiple daily injections on a national level seems to be a protective factor for developing severe hypoglycemia up to 2009.

AB - OBJECTIVE: To investigate the prevalence of severe hypoglycemia in Danish children and adolescents with type 1 diabetes and to pinpoint predictors of this acute complication in children on modern treatment modalities.RESEARCH DESIGN AND METHODS: The study is based on data from DanDiabKids, a national diabetes register for children and adolescents. The register contains data on patients with type 1 diabetes with an ascertainment rate of 99%. Data from 3320 patients aged 0-18 yr was included in the study period from 1998 to 2009 and analyzed using a negative binomial model.RESULTS: One thousand nine hundred and ninety-nine episodes of severe hypoglycemia in 867 patients were registered conferring an overall incidence of severe hypoglycemia of 15.1 [95% confident interval (CI): 13.8; 16.4] per 100 patient years. This remained unchanged during the study period. Duration of diabetes, age and treatment in centers managing less than 100 patients significantly increased the risk of severe hypoglycemia (p < 0.001). Patients on insulin pump therapy had a 42% reduced risk of severe hypoglycemia compared with pen treated patients (p = 0.01). Patients treated with five or more daily insulin injections had a 31% (95% CI: 17; 49) reduced risk of severe hypoglycemia compared to patients on fewer daily injections (p = 0.015).CONCLUSIONS: Despite improvements in metabolic control over a decade the prevalence of severe hypoglycemic events remained unchanged. More intensive treatments such as insulin pump therapy and multiple daily injections on a national level seems to be a protective factor for developing severe hypoglycemia up to 2009.

U2 - 10.1111/pedi.12171

DO - 10.1111/pedi.12171

M3 - Journal article

C2 - 25039921

VL - 16

SP - 354

EP - 360

JO - Pediatric Diabetes

JF - Pediatric Diabetes

SN - 1399-543X

IS - 5

ER -