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Presynaptic inhibition in the hippocampus

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  • S M Thompson, Brain Research Institute, University of Zurich, CH-8029 Zurich, Switzerland.
  • ,
  • M Capogna
  • M Scanziani

Presynaptic receptors for virtually all transmitters have been identified throughout the nervous system. Recent studies in the hippocampus provide new insights into the mechanisms by which the activation of these receptors leads to presynaptic inhibition of transmitter release, and characterize the second messengers involved in coupling presynaptic receptors to their effectors. Presynaptic receptors also provide a tractable route via which the amount of transmitter release may be selectively regulated in therapeutically useful ways.

Original languageEnglish
JournalTrends in Neurosciences
Pages (from-to)222-7
Number of pages6
Publication statusPublished - Jun 1993

    Research areas

  • Animals, Hippocampus/physiology, Humans, Ion Channels/physiology, Neurotransmitter Agents/metabolism, Receptors, Neurotransmitter/physiology, Synapses/physiology

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