Department of Economics and Business Economics

Prescription patterns of benzodiazepine and benzodiazepine-related drugs in the peripartum period: A population-based study

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  • Babette Bais, ISGlobal, Barcelona, Spain; Pompeu Fabra University, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands. Electronic address:
  • ,
  • Trine Munk-Olsen
  • Veerle Bergink, Department of Psychiatry, Erasmus University Medical Centre Rotterdam, Rotterdam, Netherlands; Department of Psychiatry and Department of Obstetrics Gynecology and Reproductive science, Icahn School of Medicine at Mount Sinai, New York, USA.
  • ,
  • Xiaoqin Liu

Using prescription drugs during pregnancy is challenging and approached with caution. In this study, we present population-based information on prescription patterns of benzodiazepines and benzodiazepine-related drugs in the peripartum period. A population-based study of 1,154,817 pregnancies between 1997 and 2015 in Denmark, of which 205,406 (17.8%) pregnancies in women with a psychiatric history. Prescription drugs starting with Anatomical Therapeutic Chemical codes N05BA, N05CD, and N05CF from 12 months before pregnancy to 12 months following pregnancy were identified. We used generalised estimating equations to estimate the adjusted 5 year risk difference in the proportion of women redeeming benzodiazepines from 1 year to 5 years after. Logistic regression was used to analyze the association between characteristics and discontinuation of benzodiazepines during pregnancy. The prevalence of benzodiazepine prescriptions was 1.9% before pregnancy, 0.6% during pregnancy, and 1.3% after pregnancy. In women with a psychiatric history, the prevalence was 5-6 times higher. A significant decrease in prescriptions to women with a psychiatric history was observed, which was less profound among women with no psychiatric history. Approximately 90% of women discontinue benzodiazepines during pregnancy, with a higher percentage of women discontinuing from 1997 to 2015. The observed decrease is likely explained by changing treatment guidelines.

Original languageEnglish
JournalPsychiatry Research
Pages (from-to)112993
Publication statusE-pub ahead of print - 12 Apr 2020

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