Preoperative proximal tibial bone density, bone micro-architecture, and bone turnover are not associated with postoperative tibial component migration in cemented and cementless medial unicompartmental knee replacements: secondary analyses from a randomized controlled trial

Mathias Alrø Fichtner Bendtsen; Anders Odgaard; Frank Madsen; Sebastian Breddam Mosegaard; Jesper Skovhus Thomsen; Ellen Margrethe Hauge; Kjeld Søballe; Maiken Stilling

doi:10.2340/17453674.2024.39917

Preoperative proximal tibial bone density, bone micro-architecture, and bone turnover are not associated with postoperative tibial component migration in cemented and cementless medial unicompartmental knee replacements: secondary analyses from a randomized controlled trial

Mathias Alrø Fichtner Bendtsen^*, Anders Odgaard, Frank Madsen, Sebastian Breddam Mosegaard, Jesper Skovhus Thomsen, Ellen Margrethe Hauge, Kjeld Søballe, Maiken Stilling

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Background and purpose — Cementless arthroplasty fixation relies on early bone ingrowth and may be poor in patients with low proximal tibial bone density or abnormal bone turnover. We aimed first to describe the baseline bone properties in patients undergoing medial unicompartmen-tal knee replacement (UKR), and second to investigate its association with cemented and cementless tibial component migration until 2 years. Methods — A subset investigation of 2 patient groups from a 3-armed randomized controlled trial was conducted. There were 26 cemented and 25 cementless medial UKRs with twin-pegged femoral components. Volumetric bone mineral density (vBMD) and microstructure of the excised medial tibial plateau were ascertained with µCT. Bone turnover was estimated using dynamic histomorphometry (eroded surface/bone surface = ES/BS, osteoid surface/bone surface = OS/BS, mineralizing surface/bone surface = MS/ BS). Tibial component migration in 4 feature points was followed for 2 years with radiostereometry. Results — At the 2-year follow-up, the cementless tibial components migrated 0.38 mm (95% confidence interval [CI] 0.14–0.62) total translation more than the cemented components at the posterior feature point. The greatest migration in the cementless group was subsidence at the posterior feature point of 0.66 mm (CI 0.48–0.84) until 6 weeks, and from 3 months the components were stable. Cemented tibial components subsided very little. Between 1-and 2-year follow-ups, no cementless but 4 cemented tibial components revealed continuous migration. OS/BS was half of the ES/BS. No µCT or histomorpho-metric parameters showed any clinically relevant correlation with tibial component migration at the posterior feature point for either cemented or cementless UKR at 6 weeks’ or 2 years’ follow-up after adjustment for age, BMI, and sex. Conclusion — Preoperative vBMD, bone turnover, and microstructure were not associated with postoperative tibial component migration of cemented and cementless medial UKR.

Original language	English
Journal	Acta Orthopaedica
Volume	95
Pages (from-to)	121-129
Number of pages	9
ISSN	1745-3674
DOIs	https://doi.org/10.2340/17453674.2024.39917
Publication status	Published - 2024

Access to Document

10.2340/17453674.2024.39917Licence: CC BY

Fingerprint

Dive into the research topics of 'Preoperative proximal tibial bone density, bone micro-architecture, and bone turnover are not associated with postoperative tibial component migration in cemented and cementless medial unicompartmental knee replacements: secondary analyses from a randomized controlled trial'. Together they form a unique fingerprint.

Cite this

Bendtsen, M. A. F., Odgaard, A., Madsen, F., Mosegaard, S. B., Thomsen, J. S., Hauge, E. M., Søballe, K., & Stilling, M. (2024). Preoperative proximal tibial bone density, bone micro-architecture, and bone turnover are not associated with postoperative tibial component migration in cemented and cementless medial unicompartmental knee replacements: secondary analyses from a randomized controlled trial. Acta Orthopaedica, 95, 121-129. https://doi.org/10.2340/17453674.2024.39917

Bendtsen, Mathias Alrø Fichtner ; Odgaard, Anders ; Madsen, Frank et al. / Preoperative proximal tibial bone density, bone micro-architecture, and bone turnover are not associated with postoperative tibial component migration in cemented and cementless medial unicompartmental knee replacements : secondary analyses from a randomized controlled trial. In: Acta Orthopaedica. 2024 ; Vol. 95. pp. 121-129.

@article{38dc134f2420455092f8af6889a88e9f,

title = "Preoperative proximal tibial bone density, bone micro-architecture, and bone turnover are not associated with postoperative tibial component migration in cemented and cementless medial unicompartmental knee replacements: secondary analyses from a randomized controlled trial",

abstract = "Background and purpose — Cementless arthroplasty fixation relies on early bone ingrowth and may be poor in patients with low proximal tibial bone density or abnormal bone turnover. We aimed first to describe the baseline bone properties in patients undergoing medial unicompartmen-tal knee replacement (UKR), and second to investigate its association with cemented and cementless tibial component migration until 2 years. Methods — A subset investigation of 2 patient groups from a 3-armed randomized controlled trial was conducted. There were 26 cemented and 25 cementless medial UKRs with twin-pegged femoral components. Volumetric bone mineral density (vBMD) and microstructure of the excised medial tibial plateau were ascertained with µCT. Bone turnover was estimated using dynamic histomorphometry (eroded surface/bone surface = ES/BS, osteoid surface/bone surface = OS/BS, mineralizing surface/bone surface = MS/ BS). Tibial component migration in 4 feature points was followed for 2 years with radiostereometry. Results — At the 2-year follow-up, the cementless tibial components migrated 0.38 mm (95% confidence interval [CI] 0.14–0.62) total translation more than the cemented components at the posterior feature point. The greatest migration in the cementless group was subsidence at the posterior feature point of 0.66 mm (CI 0.48–0.84) until 6 weeks, and from 3 months the components were stable. Cemented tibial components subsided very little. Between 1-and 2-year follow-ups, no cementless but 4 cemented tibial components revealed continuous migration. OS/BS was half of the ES/BS. No µCT or histomorpho-metric parameters showed any clinically relevant correlation with tibial component migration at the posterior feature point for either cemented or cementless UKR at 6 weeks{\textquoteright} or 2 years{\textquoteright} follow-up after adjustment for age, BMI, and sex. Conclusion — Preoperative vBMD, bone turnover, and microstructure were not associated with postoperative tibial component migration of cemented and cementless medial UKR.",

author = "Bendtsen, {Mathias Alr{\o} Fichtner} and Anders Odgaard and Frank Madsen and Mosegaard, {Sebastian Breddam} and Thomsen, {Jesper Skovhus} and Hauge, {Ellen Margrethe} and Kjeld S{\o}balle and Maiken Stilling",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Published by MJS Publishing – Medical Journals Sweden, on behalf of the Nordic Orthopedic Federation.",

year = "2024",

doi = "10.2340/17453674.2024.39917",

language = "English",

volume = "95",

pages = "121--129",

journal = "Acta Orthopaedica",

issn = "1745-3674",

publisher = "Medical Journals Sweden AB",

}

Bendtsen, MAF, Odgaard, A, Madsen, F, Mosegaard, SB, Thomsen, JS , Hauge, EM, Søballe, K & Stilling, M 2024, 'Preoperative proximal tibial bone density, bone micro-architecture, and bone turnover are not associated with postoperative tibial component migration in cemented and cementless medial unicompartmental knee replacements: secondary analyses from a randomized controlled trial', Acta Orthopaedica, vol. 95, pp. 121-129. https://doi.org/10.2340/17453674.2024.39917

Preoperative proximal tibial bone density, bone micro-architecture, and bone turnover are not associated with postoperative tibial component migration in cemented and cementless medial unicompartmental knee replacements: secondary analyses from a randomized controlled trial. / Bendtsen, Mathias Alrø Fichtner; Odgaard, Anders; Madsen, Frank et al.
In: Acta Orthopaedica, Vol. 95, 2024, p. 121-129.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Preoperative proximal tibial bone density, bone micro-architecture, and bone turnover are not associated with postoperative tibial component migration in cemented and cementless medial unicompartmental knee replacements

T2 - secondary analyses from a randomized controlled trial

AU - Bendtsen, Mathias Alrø Fichtner

AU - Odgaard, Anders

AU - Madsen, Frank

AU - Mosegaard, Sebastian Breddam

AU - Thomsen, Jesper Skovhus

AU - Hauge, Ellen Margrethe

AU - Søballe, Kjeld

AU - Stilling, Maiken

PY - 2024

Y1 - 2024

N2 - Background and purpose — Cementless arthroplasty fixation relies on early bone ingrowth and may be poor in patients with low proximal tibial bone density or abnormal bone turnover. We aimed first to describe the baseline bone properties in patients undergoing medial unicompartmen-tal knee replacement (UKR), and second to investigate its association with cemented and cementless tibial component migration until 2 years. Methods — A subset investigation of 2 patient groups from a 3-armed randomized controlled trial was conducted. There were 26 cemented and 25 cementless medial UKRs with twin-pegged femoral components. Volumetric bone mineral density (vBMD) and microstructure of the excised medial tibial plateau were ascertained with µCT. Bone turnover was estimated using dynamic histomorphometry (eroded surface/bone surface = ES/BS, osteoid surface/bone surface = OS/BS, mineralizing surface/bone surface = MS/ BS). Tibial component migration in 4 feature points was followed for 2 years with radiostereometry. Results — At the 2-year follow-up, the cementless tibial components migrated 0.38 mm (95% confidence interval [CI] 0.14–0.62) total translation more than the cemented components at the posterior feature point. The greatest migration in the cementless group was subsidence at the posterior feature point of 0.66 mm (CI 0.48–0.84) until 6 weeks, and from 3 months the components were stable. Cemented tibial components subsided very little. Between 1-and 2-year follow-ups, no cementless but 4 cemented tibial components revealed continuous migration. OS/BS was half of the ES/BS. No µCT or histomorpho-metric parameters showed any clinically relevant correlation with tibial component migration at the posterior feature point for either cemented or cementless UKR at 6 weeks’ or 2 years’ follow-up after adjustment for age, BMI, and sex. Conclusion — Preoperative vBMD, bone turnover, and microstructure were not associated with postoperative tibial component migration of cemented and cementless medial UKR.

AB - Background and purpose — Cementless arthroplasty fixation relies on early bone ingrowth and may be poor in patients with low proximal tibial bone density or abnormal bone turnover. We aimed first to describe the baseline bone properties in patients undergoing medial unicompartmen-tal knee replacement (UKR), and second to investigate its association with cemented and cementless tibial component migration until 2 years. Methods — A subset investigation of 2 patient groups from a 3-armed randomized controlled trial was conducted. There were 26 cemented and 25 cementless medial UKRs with twin-pegged femoral components. Volumetric bone mineral density (vBMD) and microstructure of the excised medial tibial plateau were ascertained with µCT. Bone turnover was estimated using dynamic histomorphometry (eroded surface/bone surface = ES/BS, osteoid surface/bone surface = OS/BS, mineralizing surface/bone surface = MS/ BS). Tibial component migration in 4 feature points was followed for 2 years with radiostereometry. Results — At the 2-year follow-up, the cementless tibial components migrated 0.38 mm (95% confidence interval [CI] 0.14–0.62) total translation more than the cemented components at the posterior feature point. The greatest migration in the cementless group was subsidence at the posterior feature point of 0.66 mm (CI 0.48–0.84) until 6 weeks, and from 3 months the components were stable. Cemented tibial components subsided very little. Between 1-and 2-year follow-ups, no cementless but 4 cemented tibial components revealed continuous migration. OS/BS was half of the ES/BS. No µCT or histomorpho-metric parameters showed any clinically relevant correlation with tibial component migration at the posterior feature point for either cemented or cementless UKR at 6 weeks’ or 2 years’ follow-up after adjustment for age, BMI, and sex. Conclusion — Preoperative vBMD, bone turnover, and microstructure were not associated with postoperative tibial component migration of cemented and cementless medial UKR.

UR - http://www.scopus.com/inward/record.url?scp=85185971150&partnerID=8YFLogxK

U2 - 10.2340/17453674.2024.39917

DO - 10.2340/17453674.2024.39917

M3 - Journal article

C2 - 38391197

AN - SCOPUS:85185971150

SN - 1745-3674

VL - 95

SP - 121

EP - 129

JO - Acta Orthopaedica

JF - Acta Orthopaedica

ER -

Bendtsen MAF, Odgaard A, Madsen F, Mosegaard SB, Thomsen JS , Hauge EM et al. Preoperative proximal tibial bone density, bone micro-architecture, and bone turnover are not associated with postoperative tibial component migration in cemented and cementless medial unicompartmental knee replacements: secondary analyses from a randomized controlled trial. Acta Orthopaedica. 2024;95:121-129. doi: 10.2340/17453674.2024.39917

Preoperative proximal tibial bone density, bone micro-architecture, and bone turnover are not associated with postoperative tibial component migration in cemented and cementless medial unicompartmental knee replacements: secondary analyses from a randomized controlled trial

Abstract

Access to Document

Other files and links

Fingerprint

Cite this