Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer

Henriette Ytting; Ib Jarle Christensen; Jens Christian Jensenius; Steffen Thiel; Hans Jørgen Nielsen

doi:10.1007/s00262-004-0594-9

Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer

Henriette Ytting, Ib Jarle Christensen, Jens Christian Jensenius, Steffen Thiel, Hans Jørgen Nielsen

Department of Biomedicine - Medical Microbiology and Immunology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

46 Citations (Scopus)

Abstract

Deficiency of the mannan-binding lectin (MBL) pathway of innate immunity is associated with increased susceptibility to infections. In patients with colorectal cancer (CRC), postoperative infection is associated with poor prognosis. The aim of the present study was to evaluate (1) the relation between the MBL pathway and postoperative infectious complications and survival of patients resected for CRC, and (2) the role of MBL in acute phase response compared to C-reactive protein (CRP).

Original language	English
Journal	Cancer Immunology, Immunotherapy
Volume	54
Issue	3
Pages (from-to)	265-72
Number of pages	8
ISSN	0340-7004
DOIs	https://doi.org/10.1007/s00262-004-0594-9
Publication status	Published - 2005

Keywords

Acute-Phase Reaction
C-Reactive Protein
Colorectal Neoplasms
Female
Humans
Male
Mannose-Binding Lectin
Mannose-Binding Protein-Associated Serine Proteases
Prognosis
Proportional Hazards Models
Serine Endopeptidases
Time Factors
Treatment Outcome

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10.1007/s00262-004-0594-9

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@article{77d28292351e4b7b9d1e78b5c0ea2abf,

title = "Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer",

abstract = "Deficiency of the mannan-binding lectin (MBL) pathway of innate immunity is associated with increased susceptibility to infections. In patients with colorectal cancer (CRC), postoperative infection is associated with poor prognosis. The aim of the present study was to evaluate (1) the relation between the MBL pathway and postoperative infectious complications and survival of patients resected for CRC, and (2) the role of MBL in acute phase response compared to C-reactive protein (CRP).",

keywords = "Acute-Phase Reaction, C-Reactive Protein, Colorectal Neoplasms, Female, Humans, Male, Mannose-Binding Lectin, Mannose-Binding Protein-Associated Serine Proteases, Prognosis, Proportional Hazards Models, Serine Endopeptidases, Time Factors, Treatment Outcome",

author = "Henriette Ytting and Christensen, {Ib Jarle} and Jensenius, {Jens Christian} and Steffen Thiel and Nielsen, {Hans J{\o}rgen}",

year = "2005",

doi = "10.1007/s00262-004-0594-9",

language = "English",

volume = "54",

pages = "265--72",

journal = "Cancer Immunology, Immunotherapy",

issn = "0340-7004",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "3",

}

Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer. / Ytting, Henriette; Christensen, Ib Jarle; Jensenius, Jens Christian et al.
In: Cancer Immunology, Immunotherapy, Vol. 54, No. 3, 2005, p. 265-72.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer

AU - Ytting, Henriette

AU - Christensen, Ib Jarle

AU - Jensenius, Jens Christian

AU - Thiel, Steffen

AU - Nielsen, Hans Jørgen

PY - 2005

Y1 - 2005

N2 - Deficiency of the mannan-binding lectin (MBL) pathway of innate immunity is associated with increased susceptibility to infections. In patients with colorectal cancer (CRC), postoperative infection is associated with poor prognosis. The aim of the present study was to evaluate (1) the relation between the MBL pathway and postoperative infectious complications and survival of patients resected for CRC, and (2) the role of MBL in acute phase response compared to C-reactive protein (CRP).

AB - Deficiency of the mannan-binding lectin (MBL) pathway of innate immunity is associated with increased susceptibility to infections. In patients with colorectal cancer (CRC), postoperative infection is associated with poor prognosis. The aim of the present study was to evaluate (1) the relation between the MBL pathway and postoperative infectious complications and survival of patients resected for CRC, and (2) the role of MBL in acute phase response compared to C-reactive protein (CRP).

KW - Acute-Phase Reaction

KW - C-Reactive Protein

KW - Colorectal Neoplasms

KW - Female

KW - Humans

KW - Male

KW - Mannose-Binding Lectin

KW - Mannose-Binding Protein-Associated Serine Proteases

KW - Prognosis

KW - Proportional Hazards Models

KW - Serine Endopeptidases

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1007/s00262-004-0594-9

DO - 10.1007/s00262-004-0594-9

M3 - Journal article

C2 - 15449036

SN - 0340-7004

VL - 54

SP - 265

EP - 272

JO - Cancer Immunology, Immunotherapy

JF - Cancer Immunology, Immunotherapy

IS - 3

ER -

Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer

Abstract

Keywords

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