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Prenatal Phthalate Exposure and Language Development in Toddlers from the Odense Child Cohort

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Prenatal Phthalate Exposure and Language Development in Toddlers from the Odense Child Cohort. / Olesen, Trine Staak; Bleses, Dorthe; Andersen, Helle Raun; Grandjean, Philippe ; Frederiksen, Hanne ; Trecca, Fabio; Bilenberg, Niels; Kyhl, Henriette Boye; Dalager, Louise; Jensen, Inge Kjær; Anderson, Anna-Maria ; Kold, Tina.

In: Neurotoxicology and Teratology, Vol. 65, No. January-February, 01.01.2018, p. 34-41.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Olesen, TS, Bleses, D, Andersen, HR, Grandjean, P, Frederiksen, H, Trecca, F, Bilenberg, N, Kyhl, HB, Dalager, L, Jensen, IK, Anderson, A-M & Kold, T 2018, 'Prenatal Phthalate Exposure and Language Development in Toddlers from the Odense Child Cohort' Neurotoxicology and Teratology, vol. 65, no. January-February, pp. 34-41. https://doi.org/10.1016/j.ntt.2017.11.004

APA

Olesen, T. S., Bleses, D., Andersen, H. R., Grandjean, P., Frederiksen, H., Trecca, F., ... Kold, T. (2018). Prenatal Phthalate Exposure and Language Development in Toddlers from the Odense Child Cohort. Neurotoxicology and Teratology, 65(January-February), 34-41. https://doi.org/10.1016/j.ntt.2017.11.004

CBE

Olesen TS, Bleses D, Andersen HR, Grandjean P, Frederiksen H, Trecca F, Bilenberg N, Kyhl HB, Dalager L, Jensen IK, Anderson A-M, Kold T. 2018. Prenatal Phthalate Exposure and Language Development in Toddlers from the Odense Child Cohort. Neurotoxicology and Teratology. 65(January-February):34-41. https://doi.org/10.1016/j.ntt.2017.11.004

MLA

Olesen, Trine Staak et al. "Prenatal Phthalate Exposure and Language Development in Toddlers from the Odense Child Cohort". Neurotoxicology and Teratology. 2018, 65(January-February). 34-41. https://doi.org/10.1016/j.ntt.2017.11.004

Vancouver

Olesen TS, Bleses D, Andersen HR, Grandjean P, Frederiksen H, Trecca F et al. Prenatal Phthalate Exposure and Language Development in Toddlers from the Odense Child Cohort. Neurotoxicology and Teratology. 2018 Jan 1;65(January-February):34-41. https://doi.org/10.1016/j.ntt.2017.11.004

Author

Olesen, Trine Staak ; Bleses, Dorthe ; Andersen, Helle Raun ; Grandjean, Philippe ; Frederiksen, Hanne ; Trecca, Fabio ; Bilenberg, Niels ; Kyhl, Henriette Boye ; Dalager, Louise ; Jensen, Inge Kjær ; Anderson, Anna-Maria ; Kold, Tina. / Prenatal Phthalate Exposure and Language Development in Toddlers from the Odense Child Cohort. In: Neurotoxicology and Teratology. 2018 ; Vol. 65, No. January-February. pp. 34-41.

Bibtex

@article{da503f9f963341dc970d4e0640c276de,
title = "Prenatal Phthalate Exposure and Language Development in Toddlers from the Odense Child Cohort",
abstract = "BackgroundPhthalates are a group of chemicals found in a variety of consumer products. They have anti-androgenic properties and human studies have reported associations between prenatal phthalate exposure and neuropsychological development in the offspring despite different cognitive tests, different ages and varying timing of exposure.ObjectivesTo investigate the association between prenatal phthalate exposure and language development in children aged 20–36 months.MethodsIn the Odense Child Cohort, we analyzed 3rd trimester urine samples of 518 pregnant women for content of metabolites of diethyl, di-n-butyl, diisobutyl, butylbenzyl, di(2-ethylhexyl), and diisononyl phthalate, adjusted for osmolality. Language development was addressed using the Danish version of the MacArthur-Bates Communicative Development Inventories “Words and Sentences”. Associations were assessed using logistic regression models comparing children below and above the 15th percentile while stratifying by sex and adjusting for maternal age and educational level.ResultsPhthalate metabolites were detectable in all samples although in lower levels than previous studies. Among boys, increased prenatal phthalate exposure was associated with lower scores in language development; odds ratios for vocabulary score below the 15th percentile with doubling in monoethyl phthalate, and summed di-(2-ethylhexyl) phthalate metabolites were respectively 1.24 (95{\%} confidence interval: 1.05,1.46), and 1.33 (1.01,1.75). Similar associations were found for language complexity. No associations were found for girls.ConclusionsOur findings are notable, as adverse associations were suggested even in this low-level exposed population, with only one spot urine sample for exposure assessment and control for confounders. Lower scores in early language development are of relevance to health as this test predicts later educational success.",
keywords = "ACID, CHEMICALS, DANISH, DUST, ESTERS, HEALTH, METABOLITES, PREGNANT-WOMEN, RISK, URINE SAMPLES",
author = "Olesen, {Trine Staak} and Dorthe Bleses and Andersen, {Helle Raun} and Philippe Grandjean and Hanne Frederiksen and Fabio Trecca and Niels Bilenberg and Kyhl, {Henriette Boye} and Louise Dalager and Jensen, {Inge Kj{\ae}r} and Anna-Maria Anderson and Tina Kold",
note = "Copyright {\circledC} 2017. Published by Elsevier Inc.",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.ntt.2017.11.004",
language = "English",
volume = "65",
pages = "34--41",
journal = "Neurotoxicology and Teratology",
issn = "0892-0362",
publisher = "Elsevier Inc",
number = "January-February",

}

RIS

TY - JOUR

T1 - Prenatal Phthalate Exposure and Language Development in Toddlers from the Odense Child Cohort

AU - Olesen, Trine Staak

AU - Bleses, Dorthe

AU - Andersen, Helle Raun

AU - Grandjean, Philippe

AU - Frederiksen, Hanne

AU - Trecca, Fabio

AU - Bilenberg, Niels

AU - Kyhl, Henriette Boye

AU - Dalager, Louise

AU - Jensen, Inge Kjær

AU - Anderson, Anna-Maria

AU - Kold, Tina

N1 - Copyright © 2017. Published by Elsevier Inc.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - BackgroundPhthalates are a group of chemicals found in a variety of consumer products. They have anti-androgenic properties and human studies have reported associations between prenatal phthalate exposure and neuropsychological development in the offspring despite different cognitive tests, different ages and varying timing of exposure.ObjectivesTo investigate the association between prenatal phthalate exposure and language development in children aged 20–36 months.MethodsIn the Odense Child Cohort, we analyzed 3rd trimester urine samples of 518 pregnant women for content of metabolites of diethyl, di-n-butyl, diisobutyl, butylbenzyl, di(2-ethylhexyl), and diisononyl phthalate, adjusted for osmolality. Language development was addressed using the Danish version of the MacArthur-Bates Communicative Development Inventories “Words and Sentences”. Associations were assessed using logistic regression models comparing children below and above the 15th percentile while stratifying by sex and adjusting for maternal age and educational level.ResultsPhthalate metabolites were detectable in all samples although in lower levels than previous studies. Among boys, increased prenatal phthalate exposure was associated with lower scores in language development; odds ratios for vocabulary score below the 15th percentile with doubling in monoethyl phthalate, and summed di-(2-ethylhexyl) phthalate metabolites were respectively 1.24 (95% confidence interval: 1.05,1.46), and 1.33 (1.01,1.75). Similar associations were found for language complexity. No associations were found for girls.ConclusionsOur findings are notable, as adverse associations were suggested even in this low-level exposed population, with only one spot urine sample for exposure assessment and control for confounders. Lower scores in early language development are of relevance to health as this test predicts later educational success.

AB - BackgroundPhthalates are a group of chemicals found in a variety of consumer products. They have anti-androgenic properties and human studies have reported associations between prenatal phthalate exposure and neuropsychological development in the offspring despite different cognitive tests, different ages and varying timing of exposure.ObjectivesTo investigate the association between prenatal phthalate exposure and language development in children aged 20–36 months.MethodsIn the Odense Child Cohort, we analyzed 3rd trimester urine samples of 518 pregnant women for content of metabolites of diethyl, di-n-butyl, diisobutyl, butylbenzyl, di(2-ethylhexyl), and diisononyl phthalate, adjusted for osmolality. Language development was addressed using the Danish version of the MacArthur-Bates Communicative Development Inventories “Words and Sentences”. Associations were assessed using logistic regression models comparing children below and above the 15th percentile while stratifying by sex and adjusting for maternal age and educational level.ResultsPhthalate metabolites were detectable in all samples although in lower levels than previous studies. Among boys, increased prenatal phthalate exposure was associated with lower scores in language development; odds ratios for vocabulary score below the 15th percentile with doubling in monoethyl phthalate, and summed di-(2-ethylhexyl) phthalate metabolites were respectively 1.24 (95% confidence interval: 1.05,1.46), and 1.33 (1.01,1.75). Similar associations were found for language complexity. No associations were found for girls.ConclusionsOur findings are notable, as adverse associations were suggested even in this low-level exposed population, with only one spot urine sample for exposure assessment and control for confounders. Lower scores in early language development are of relevance to health as this test predicts later educational success.

KW - ACID

KW - CHEMICALS

KW - DANISH

KW - DUST

KW - ESTERS

KW - HEALTH

KW - METABOLITES

KW - PREGNANT-WOMEN

KW - RISK

KW - URINE SAMPLES

UR - http://www.scopus.com/inward/record.url?scp=85037653893&partnerID=8YFLogxK

U2 - 10.1016/j.ntt.2017.11.004

DO - 10.1016/j.ntt.2017.11.004

M3 - Journal article

VL - 65

SP - 34

EP - 41

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

IS - January-February

ER -