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Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20 years of age

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BACKGROUND: Prenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year old offspring.

METHODS: In a Danish cohort of 965 pregnant women established in 1988-89, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p'-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n=872). At age 20 years, 416 offspring (45% of those invited) attended a clinical examination including measurements of allergic sensitization (serum specific IgE > 0.35 kUA /L) and lung function (forced expiratory volume in one second (FEV1 ) and forced vital capacity (FVC)).

RESULTS: There were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1 /FVC<75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14-7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p'-DDE were 2.68 (1.06-6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1 %predicted value<90%).

CONCLUSION AND CLINICAL RELEVANCE: Our data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20-years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalClinical and Experimental Allergy
Volume46
Issue2
Pages (from-to)329-336
Number of pages8
ISSN0954-7894
DOIs
Publication statusPublished - 2016

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