Predicting stroke in patients without atrial fibrillation

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Predicting stroke in patients without atrial fibrillation. / Steensig, Kamilla; Olesen, Kevin K W; Thim, Troels; Nielsen, Jens C; Madsen, Morten; Jensen, Svend E; Jensen, Lisette O; Kristensen, Steen D; Lip, Gregory Y H; Maeng, Michael.

In: European Journal of Clinical Investigation, Vol. 49, No. 6, e13103, 06.2019.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Steensig, K, Olesen, KKW, Thim, T, Nielsen, JC, Madsen, M, Jensen, SE, Jensen, LO, Kristensen, SD, Lip, GYH & Maeng, M 2019, 'Predicting stroke in patients without atrial fibrillation', European Journal of Clinical Investigation, vol. 49, no. 6, e13103. https://doi.org/10.1111/eci.13103

APA

Steensig, K., Olesen, K. K. W., Thim, T., Nielsen, J. C., Madsen, M., Jensen, S. E., Jensen, L. O., Kristensen, S. D., Lip, G. Y. H., & Maeng, M. (2019). Predicting stroke in patients without atrial fibrillation. European Journal of Clinical Investigation, 49(6), [e13103]. https://doi.org/10.1111/eci.13103

CBE

Steensig K, Olesen KKW, Thim T, Nielsen JC, Madsen M, Jensen SE, Jensen LO, Kristensen SD, Lip GYH, Maeng M. 2019. Predicting stroke in patients without atrial fibrillation. European Journal of Clinical Investigation. 49(6):Article e13103. https://doi.org/10.1111/eci.13103

MLA

Steensig, Kamilla et al. "Predicting stroke in patients without atrial fibrillation". European Journal of Clinical Investigation. 2019. 49(6). https://doi.org/10.1111/eci.13103

Vancouver

Steensig K, Olesen KKW, Thim T, Nielsen JC, Madsen M, Jensen SE et al. Predicting stroke in patients without atrial fibrillation. European Journal of Clinical Investigation. 2019 Jun;49(6). e13103. https://doi.org/10.1111/eci.13103

Author

Steensig, Kamilla ; Olesen, Kevin K W ; Thim, Troels ; Nielsen, Jens C ; Madsen, Morten ; Jensen, Svend E ; Jensen, Lisette O ; Kristensen, Steen D ; Lip, Gregory Y H ; Maeng, Michael. / Predicting stroke in patients without atrial fibrillation. In: European Journal of Clinical Investigation. 2019 ; Vol. 49, No. 6.

Bibtex

@article{329a2086519a4037a346823b90d8ded3,
title = "Predicting stroke in patients without atrial fibrillation",
abstract = "Background: Only few studies in selected cohorts have examined whether the CHA 2DS 2-VASc score can predict the risk of atrial fibrillation and thromboembolic events in patients without atrial fibrillation. Materials and methods: Patients with coronary angiography performed between 2004 and 2012 were grouped according to CHA 2DS 2-VASc score. We excluded patients with atrial fibrillation, anticoagulant therapy and follow-up <30 days. The endpoints were atrial fibrillation and a composite of ischaemic stroke, transient ischaemic attack and systemic embolism. Event rates per 100 person-years were estimated for each CHA 2DS 2-VASc score (0, 1, 2, 3, 4, and >4). Incidence rate ratios were calculated using low-risk patients (CHA 2DS 2-VASc score 0 in males or 1 in females) as reference. Results: In total, 78 233 patients were included with group sizes varying between 8299 (CHA 2DS 2-VASc >4) and 19 882 (CHA 2DS 2-VASc 2). An increasing CHA 2DS 2-VASc score was significantly associated with a future diagnosis of atrial fibrillation (P for trend <0.0001) and an incremental risk of ischaemic stroke, transient ischaemic attack, systemic embolism (P for trend <0.0001) and all-cause death (P for trend <0.0001). Patients with a CHA 2DS 2-VASc score of 3 had a rate of ischaemic stroke/transient ischaemic attack/systemic embolism of 1.30 per 100 person-years. Conclusions: Among patients undergoing coronary angiography, the CHA 2DS 2-VASc score predicted a future diagnosis of atrial fibrillation and the composite risk of ischaemic stroke, transient ischaemic attack or systemic embolism in patients without atrial fibrillation. A CHA 2DS 2-VASc score of 3 was associated with a risk that would justify prophylactic oral anticoagulation treatment in a patient with atrial fibrillation. ",
keywords = "CHA DS -VASc, coronary angiography, coronary artery disease, prevention, stroke, thromboembolism, ANTICOAGULANTS, RISK STRATIFICATION, GUIDELINES, PREVENTION, CHADS(2), CHA(2)DS(2)-VASc, HEART, DISEASE, REGISTRY",
author = "Kamilla Steensig and Olesen, {Kevin K W} and Troels Thim and Nielsen, {Jens C} and Morten Madsen and Jensen, {Svend E} and Jensen, {Lisette O} and Kristensen, {Steen D} and Lip, {Gregory Y H} and Michael Maeng",
note = "This article is protected by copyright. All rights reserved.",
year = "2019",
month = jun,
doi = "10.1111/eci.13103",
language = "English",
volume = "49",
journal = "European Journal of Clinical Investigation",
issn = "0014-2972",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "6",

}

RIS

TY - JOUR

T1 - Predicting stroke in patients without atrial fibrillation

AU - Steensig, Kamilla

AU - Olesen, Kevin K W

AU - Thim, Troels

AU - Nielsen, Jens C

AU - Madsen, Morten

AU - Jensen, Svend E

AU - Jensen, Lisette O

AU - Kristensen, Steen D

AU - Lip, Gregory Y H

AU - Maeng, Michael

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/6

Y1 - 2019/6

N2 - Background: Only few studies in selected cohorts have examined whether the CHA 2DS 2-VASc score can predict the risk of atrial fibrillation and thromboembolic events in patients without atrial fibrillation. Materials and methods: Patients with coronary angiography performed between 2004 and 2012 were grouped according to CHA 2DS 2-VASc score. We excluded patients with atrial fibrillation, anticoagulant therapy and follow-up <30 days. The endpoints were atrial fibrillation and a composite of ischaemic stroke, transient ischaemic attack and systemic embolism. Event rates per 100 person-years were estimated for each CHA 2DS 2-VASc score (0, 1, 2, 3, 4, and >4). Incidence rate ratios were calculated using low-risk patients (CHA 2DS 2-VASc score 0 in males or 1 in females) as reference. Results: In total, 78 233 patients were included with group sizes varying between 8299 (CHA 2DS 2-VASc >4) and 19 882 (CHA 2DS 2-VASc 2). An increasing CHA 2DS 2-VASc score was significantly associated with a future diagnosis of atrial fibrillation (P for trend <0.0001) and an incremental risk of ischaemic stroke, transient ischaemic attack, systemic embolism (P for trend <0.0001) and all-cause death (P for trend <0.0001). Patients with a CHA 2DS 2-VASc score of 3 had a rate of ischaemic stroke/transient ischaemic attack/systemic embolism of 1.30 per 100 person-years. Conclusions: Among patients undergoing coronary angiography, the CHA 2DS 2-VASc score predicted a future diagnosis of atrial fibrillation and the composite risk of ischaemic stroke, transient ischaemic attack or systemic embolism in patients without atrial fibrillation. A CHA 2DS 2-VASc score of 3 was associated with a risk that would justify prophylactic oral anticoagulation treatment in a patient with atrial fibrillation.

AB - Background: Only few studies in selected cohorts have examined whether the CHA 2DS 2-VASc score can predict the risk of atrial fibrillation and thromboembolic events in patients without atrial fibrillation. Materials and methods: Patients with coronary angiography performed between 2004 and 2012 were grouped according to CHA 2DS 2-VASc score. We excluded patients with atrial fibrillation, anticoagulant therapy and follow-up <30 days. The endpoints were atrial fibrillation and a composite of ischaemic stroke, transient ischaemic attack and systemic embolism. Event rates per 100 person-years were estimated for each CHA 2DS 2-VASc score (0, 1, 2, 3, 4, and >4). Incidence rate ratios were calculated using low-risk patients (CHA 2DS 2-VASc score 0 in males or 1 in females) as reference. Results: In total, 78 233 patients were included with group sizes varying between 8299 (CHA 2DS 2-VASc >4) and 19 882 (CHA 2DS 2-VASc 2). An increasing CHA 2DS 2-VASc score was significantly associated with a future diagnosis of atrial fibrillation (P for trend <0.0001) and an incremental risk of ischaemic stroke, transient ischaemic attack, systemic embolism (P for trend <0.0001) and all-cause death (P for trend <0.0001). Patients with a CHA 2DS 2-VASc score of 3 had a rate of ischaemic stroke/transient ischaemic attack/systemic embolism of 1.30 per 100 person-years. Conclusions: Among patients undergoing coronary angiography, the CHA 2DS 2-VASc score predicted a future diagnosis of atrial fibrillation and the composite risk of ischaemic stroke, transient ischaemic attack or systemic embolism in patients without atrial fibrillation. A CHA 2DS 2-VASc score of 3 was associated with a risk that would justify prophylactic oral anticoagulation treatment in a patient with atrial fibrillation.

KW - CHA DS -VASc

KW - coronary angiography

KW - coronary artery disease

KW - prevention

KW - stroke

KW - thromboembolism

KW - ANTICOAGULANTS

KW - RISK STRATIFICATION

KW - GUIDELINES

KW - PREVENTION

KW - CHADS(2)

KW - CHA(2)DS(2)-VASc

KW - HEART

KW - DISEASE

KW - REGISTRY

UR - http://www.scopus.com/inward/record.url?scp=85063797109&partnerID=8YFLogxK

U2 - 10.1111/eci.13103

DO - 10.1111/eci.13103

M3 - Journal article

C2 - 30883728

VL - 49

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

SN - 0014-2972

IS - 6

M1 - e13103

ER -