Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles

Carla Bartosch; Alfons Nadal; Ana C. Braga; Angela Salerno; Anne Laure Rougemont; Anne Sophie Van Rompuy; Brendan Fitzgerald; Caroline Joyce; Fabienne Allias; Geoffrey J. Maher; Gitta Turowski; Jean Christophe Tille; Kinan Drak Alsibai; Koen Van de Vijver; Lesley McMahon; Lone Sunde; Michal Pyzlak; Paul Downey; Sandra Wessman; Sophie Patrier; Baljeet Kaur; Rosemary Fisher

doi:10.1007/s00428-023-03658-8

Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles

Carla Bartosch^*, Alfons Nadal, Ana C. Braga, Angela Salerno, Anne Laure Rougemont, Anne Sophie Van Rompuy, Brendan Fitzgerald, Caroline Joyce, Fabienne Allias, Geoffrey J. Maher, Gitta Turowski, Jean Christophe Tille, Kinan Drak Alsibai, Koen Van de Vijver, Lesley McMahon, Lone Sunde, Michal Pyzlak, Paul Downey, Sandra Wessman, Sophie PatrierBaljeet Kaur, Rosemary Fisher

^*Corresponding author for this work

Department of Biomedicine - Forskning og uddannelse, Skou-bygningen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

4 Citations (Scopus)

Abstract

Hydatidiform moles are rare and thus most pathologists and geneticists have little experience with their diagnosis. It is important to promptly and correctly identify hydatidiform moles given that they are premalignant disorders associated with a risk of persistent gestational trophoblastic disease and gestational trophoblastic neoplasia. Improvement in diagnosis can be achieved with uniformization of diagnostic criteria and establishment of algorithms. To this aim, the Pathology and Genetics Working Party of the European Organisation for Treatment of Trophoblastic Diseases has developed guidelines that describe the pathological criteria and ancillary techniques that can be used in the differential diagnosis of hydatidiform moles. These guidelines are based on the best available evidence in the literature, professional experience and consensus of the experts’ group involved in its development.

Original language	English
Journal	Virchows Archiv
Volume	484
Issue	3
Pages (from-to)	401-422
Number of pages	22
ISSN	0945-6317
DOIs	https://doi.org/10.1007/s00428-023-03658-8
Publication status	Published - Mar 2024

Keywords

Diagnosis
Genetics
Genotyping
Guidelines
Hydatidiform moles
Pathology

Access to Document

10.1007/s00428-023-03658-8

Cite this

Bartosch, C., Nadal, A., Braga, A. C., Salerno, A., Rougemont, A. L., Van Rompuy, A. S., Fitzgerald, B., Joyce, C., Allias, F., Maher, G. J., Turowski, G., Tille, J. C., Alsibai, K. D., Van de Vijver, K., McMahon, L., Sunde, L., Pyzlak, M., Downey, P., Wessman, S., ... Fisher, R. (2024). Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles. Virchows Archiv, 484(3), 401-422. https://doi.org/10.1007/s00428-023-03658-8

@article{8759bbacf53d46a79b77b65a3e350d20,

title = "Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles",

abstract = "Hydatidiform moles are rare and thus most pathologists and geneticists have little experience with their diagnosis. It is important to promptly and correctly identify hydatidiform moles given that they are premalignant disorders associated with a risk of persistent gestational trophoblastic disease and gestational trophoblastic neoplasia. Improvement in diagnosis can be achieved with uniformization of diagnostic criteria and establishment of algorithms. To this aim, the Pathology and Genetics Working Party of the European Organisation for Treatment of Trophoblastic Diseases has developed guidelines that describe the pathological criteria and ancillary techniques that can be used in the differential diagnosis of hydatidiform moles. These guidelines are based on the best available evidence in the literature, professional experience and consensus of the experts{\textquoteright} group involved in its development.",

keywords = "Diagnosis, Genetics, Genotyping, Guidelines, Hydatidiform moles, Pathology",

author = "Carla Bartosch and Alfons Nadal and Braga, {Ana C.} and Angela Salerno and Rougemont, {Anne Laure} and {Van Rompuy}, {Anne Sophie} and Brendan Fitzgerald and Caroline Joyce and Fabienne Allias and Maher, {Geoffrey J.} and Gitta Turowski and Tille, {Jean Christophe} and Alsibai, {Kinan Drak} and {Van de Vijver}, Koen and Lesley McMahon and Lone Sunde and Michal Pyzlak and Paul Downey and Sandra Wessman and Sophie Patrier and Baljeet Kaur and Rosemary Fisher",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. corrected publication 2023.",

year = "2024",

month = mar,

doi = "10.1007/s00428-023-03658-8",

language = "English",

volume = "484",

pages = "401--422",

journal = "Virchows Archiv",

issn = "0945-6317",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "3",

}

Bartosch, C, Nadal, A, Braga, AC, Salerno, A, Rougemont, AL, Van Rompuy, AS, Fitzgerald, B, Joyce, C, Allias, F, Maher, GJ, Turowski, G, Tille, JC, Alsibai, KD, Van de Vijver, K, McMahon, L, Sunde, L, Pyzlak, M, Downey, P, Wessman, S, Patrier, S, Kaur, B & Fisher, R 2024, 'Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles', Virchows Archiv, vol. 484, no. 3, pp. 401-422. https://doi.org/10.1007/s00428-023-03658-8

TY - JOUR

T1 - Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles

AU - Bartosch, Carla

AU - Nadal, Alfons

AU - Braga, Ana C.

AU - Salerno, Angela

AU - Rougemont, Anne Laure

AU - Van Rompuy, Anne Sophie

AU - Fitzgerald, Brendan

AU - Joyce, Caroline

AU - Allias, Fabienne

AU - Maher, Geoffrey J.

AU - Turowski, Gitta

AU - Tille, Jean Christophe

AU - Alsibai, Kinan Drak

AU - Van de Vijver, Koen

AU - McMahon, Lesley

AU - Sunde, Lone

AU - Pyzlak, Michal

AU - Downey, Paul

AU - Wessman, Sandra

AU - Patrier, Sophie

AU - Kaur, Baljeet

AU - Fisher, Rosemary

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. corrected publication 2023.

PY - 2024/3

Y1 - 2024/3

N2 - Hydatidiform moles are rare and thus most pathologists and geneticists have little experience with their diagnosis. It is important to promptly and correctly identify hydatidiform moles given that they are premalignant disorders associated with a risk of persistent gestational trophoblastic disease and gestational trophoblastic neoplasia. Improvement in diagnosis can be achieved with uniformization of diagnostic criteria and establishment of algorithms. To this aim, the Pathology and Genetics Working Party of the European Organisation for Treatment of Trophoblastic Diseases has developed guidelines that describe the pathological criteria and ancillary techniques that can be used in the differential diagnosis of hydatidiform moles. These guidelines are based on the best available evidence in the literature, professional experience and consensus of the experts’ group involved in its development.

AB - Hydatidiform moles are rare and thus most pathologists and geneticists have little experience with their diagnosis. It is important to promptly and correctly identify hydatidiform moles given that they are premalignant disorders associated with a risk of persistent gestational trophoblastic disease and gestational trophoblastic neoplasia. Improvement in diagnosis can be achieved with uniformization of diagnostic criteria and establishment of algorithms. To this aim, the Pathology and Genetics Working Party of the European Organisation for Treatment of Trophoblastic Diseases has developed guidelines that describe the pathological criteria and ancillary techniques that can be used in the differential diagnosis of hydatidiform moles. These guidelines are based on the best available evidence in the literature, professional experience and consensus of the experts’ group involved in its development.

KW - Diagnosis

KW - Genetics

KW - Genotyping

KW - Guidelines

KW - Hydatidiform moles

KW - Pathology

UR - http://www.scopus.com/inward/record.url?scp=85174416615&partnerID=8YFLogxK

U2 - 10.1007/s00428-023-03658-8

DO - 10.1007/s00428-023-03658-8

M3 - Review

C2 - 37857997

AN - SCOPUS:85174416615

SN - 0945-6317

VL - 484

SP - 401

EP - 422

JO - Virchows Archiv

JF - Virchows Archiv

IS - 3

ER -

Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this