Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Ditte Emilie Munk; Frederik Teicher Kirk; Mikkel Vendelbo; Karina Vase; Ole Munk; Peter Ott; Thomas Damgaard Sandahl

doi:10.3791/65109

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Ditte Emilie Munk^*, Frederik Teicher Kirk, Mikkel Vendelbo, Karina Vase, Ole Munk, Peter Ott, Thomas Damgaard Sandahl

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2 Citations (Scopus)

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Abstract

Copper is an essential trace element, functioning in catalysis and signaling in biological systems. Radiolabeled copper has been used for decades in studying basic human and animal copper metabolism and copper-related disorders, such as Wilson disease (WD) and Menke's disease. A recent addition to this toolkit is 64-copper (⁶⁴ Cu) positron emission tomography (PET), combining the accurate anatomical imaging of modern computed tomography (CT) or magnetic resonance imaging (MRI) scanners with the biodistribution of the⁶⁴ Cu PET tracer signal. This allows the in vivo tracking of copper fluxes and kinetics, thereby directly visualizing human and animal copper organ traffic and metabolism. Consequently,⁶⁴ Cu PET is well-suited for evaluating clinical and preclinical treatment effects and has already demonstrated the ability to diagnose WD accurately. Furthermore,⁶⁴ Cu PET/CT studies have proven valuable in other scientific areas like cancer and stroke research. The present article shows how to perform⁶⁴ Cu PET/CT or PET/MR in humans. Procedures for⁶⁴ Cu handling, patient preparation, and scanner setup are demonstrated here.

Original language	English
Article number	e65109
Journal	Journal of Visualized Experiments
Volume	194
Number of pages	11
ISSN	1940-087X
DOIs	https://doi.org/10.3791/65109
Publication status	Published - Apr 2023

Keywords

Animals
Copper Radioisotopes
Copper/metabolism
Hepatolenticular Degeneration/metabolism
Humans
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography/methods
Tissue Distribution

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Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related DisordersFinal published version, 602 KB

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title = "Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders",

abstract = "Copper is an essential trace element, functioning in catalysis and signaling in biological systems. Radiolabeled copper has been used for decades in studying basic human and animal copper metabolism and copper-related disorders, such as Wilson disease (WD) and Menke's disease. A recent addition to this toolkit is 64-copper (64 Cu) positron emission tomography (PET), combining the accurate anatomical imaging of modern computed tomography (CT) or magnetic resonance imaging (MRI) scanners with the biodistribution of the64 Cu PET tracer signal. This allows the in vivo tracking of copper fluxes and kinetics, thereby directly visualizing human and animal copper organ traffic and metabolism. Consequently,64 Cu PET is well-suited for evaluating clinical and preclinical treatment effects and has already demonstrated the ability to diagnose WD accurately. Furthermore,64 Cu PET/CT studies have proven valuable in other scientific areas like cancer and stroke research. The present article shows how to perform64 Cu PET/CT or PET/MR in humans. Procedures for64 Cu handling, patient preparation, and scanner setup are demonstrated here.",

keywords = "Animals, Copper Radioisotopes, Copper/metabolism, Hepatolenticular Degeneration/metabolism, Humans, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography/methods, Tissue Distribution",

author = "Munk, {Ditte Emilie} and Kirk, {Frederik Teicher} and Mikkel Vendelbo and Karina Vase and Ole Munk and Peter Ott and Sandahl, {Thomas Damgaard}",

year = "2023",

month = apr,

doi = "10.3791/65109",

language = "English",

volume = "194",

journal = "Journal of Visualized Experiments",

issn = "1940-087X",

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Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders. / Munk, Ditte Emilie ; Kirk, Frederik Teicher ; Vendelbo, Mikkel et al.
In: Journal of Visualized Experiments, Vol. 194, e65109, 04.2023.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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AU - Munk, Ditte Emilie

AU - Kirk, Frederik Teicher

AU - Vendelbo, Mikkel

AU - Vase, Karina

AU - Munk, Ole

AU - Ott, Peter

AU - Sandahl, Thomas Damgaard

PY - 2023/4

Y1 - 2023/4

N2 - Copper is an essential trace element, functioning in catalysis and signaling in biological systems. Radiolabeled copper has been used for decades in studying basic human and animal copper metabolism and copper-related disorders, such as Wilson disease (WD) and Menke's disease. A recent addition to this toolkit is 64-copper (64 Cu) positron emission tomography (PET), combining the accurate anatomical imaging of modern computed tomography (CT) or magnetic resonance imaging (MRI) scanners with the biodistribution of the64 Cu PET tracer signal. This allows the in vivo tracking of copper fluxes and kinetics, thereby directly visualizing human and animal copper organ traffic and metabolism. Consequently,64 Cu PET is well-suited for evaluating clinical and preclinical treatment effects and has already demonstrated the ability to diagnose WD accurately. Furthermore,64 Cu PET/CT studies have proven valuable in other scientific areas like cancer and stroke research. The present article shows how to perform64 Cu PET/CT or PET/MR in humans. Procedures for64 Cu handling, patient preparation, and scanner setup are demonstrated here.

AB - Copper is an essential trace element, functioning in catalysis and signaling in biological systems. Radiolabeled copper has been used for decades in studying basic human and animal copper metabolism and copper-related disorders, such as Wilson disease (WD) and Menke's disease. A recent addition to this toolkit is 64-copper (64 Cu) positron emission tomography (PET), combining the accurate anatomical imaging of modern computed tomography (CT) or magnetic resonance imaging (MRI) scanners with the biodistribution of the64 Cu PET tracer signal. This allows the in vivo tracking of copper fluxes and kinetics, thereby directly visualizing human and animal copper organ traffic and metabolism. Consequently,64 Cu PET is well-suited for evaluating clinical and preclinical treatment effects and has already demonstrated the ability to diagnose WD accurately. Furthermore,64 Cu PET/CT studies have proven valuable in other scientific areas like cancer and stroke research. The present article shows how to perform64 Cu PET/CT or PET/MR in humans. Procedures for64 Cu handling, patient preparation, and scanner setup are demonstrated here.

KW - Animals

KW - Copper Radioisotopes

KW - Copper/metabolism

KW - Hepatolenticular Degeneration/metabolism

KW - Humans

KW - Positron Emission Tomography Computed Tomography

KW - Positron-Emission Tomography/methods

KW - Tissue Distribution

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DO - 10.3791/65109

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C2 - 37184248

AN - SCOPUS:85159405972

SN - 1940-087X

VL - 194

JO - Journal of Visualized Experiments

JF - Journal of Visualized Experiments

M1 - e65109

ER -

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

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