Positive predictive value of the giant cell arteritis diagnosis in the danish national patient registry: A validation study

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Positive predictive value of the giant cell arteritis diagnosis in the danish national patient registry : A validation study. / Hjort, Peter Engholm; Therkildsen, Philip; Nielsen, Berit Dalsgaard; Hansen, Ib Tønder; Nørgaard, Mette; de Thurah, Annette; Hauge, Ellen Margrethe.

In: Clinical epidemiology, Vol. 12, 2020, p. 731-736.

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@article{693d3c004f5d4323b9a8d235527aa1f9,
title = "Positive predictive value of the giant cell arteritis diagnosis in the danish national patient registry: A validation study",
abstract = "Purpose: To investigate the positive predictive value (PPV) of the giant cell arteritis (GCA) diagnosis in the Danish National Patient Registry (DNPR). Patients and Methods: A total of 293 patients aged ≥50 years with a first-time diagnosis of GCA in the DNPR between January 2012 and December 2017 were included. Patients were sampled from two secondary and one tertiary care hospitals in the Central Region Denmark. Two independent investigators (PH & PT) reviewed all medical files, including medical records, treatment, biochemistry, histopathology and imaging, and either confirmed or dismissed the diagnosis of GCA. In case of disagreement, a consensus agreement was reached. Sub-analyses including number of redeemed prescriptions performed temporal artery biopsies (TABs), and number of GCA-related hospital contacts were performed. Results: We confirmed the diagnosis of GCA in 183/293 patients resulting in a PPV of 62% (95% CI: 57–68). In patients with ≥3 redeemed prescriptions of glucocorticoids (GCs), we confirmed the diagnosis in 166/214 resulting in a PPV of 78% (95% CI: 71–83). In patients with ≥3 redeemed prescriptions of GCs and ≥3 GCA-related hospital contacts, we confirmed the diagnosis in 88/95 resulting in a PPV of 93% (95% CI: 85–96); however, this only included 88/183 confirmed GCA patients. Conclusion: This is the first study to validate the diagnostic code of GCA in the DNPR. The overall PPVof GCA in the DNPR was 62%. Requiring redeemed prescriptions of GCs and/or GCA-related hospital contacts increase the PPV, but also excludes a significant number of GCA patients.",
keywords = "Danish National Patient Registry, Giant cell arteritis, Positive predictive value, Rheumatology, Validation",
author = "Hjort, {Peter Engholm} and Philip Therkildsen and Nielsen, {Berit Dalsgaard} and Hansen, {Ib T{\o}nder} and Mette N{\o}rgaard and {de Thurah}, Annette and Hauge, {Ellen Margrethe}",
year = "2020",
doi = "10.2147/CLEP.S258219",
language = "English",
volume = "12",
pages = "731--736",
journal = "Clinical Epidemiology",
issn = "1179-1349",
publisher = "Dove Medical Press Ltd.(Dovepress)",

}

RIS

TY - JOUR

T1 - Positive predictive value of the giant cell arteritis diagnosis in the danish national patient registry

T2 - A validation study

AU - Hjort, Peter Engholm

AU - Therkildsen, Philip

AU - Nielsen, Berit Dalsgaard

AU - Hansen, Ib Tønder

AU - Nørgaard, Mette

AU - de Thurah, Annette

AU - Hauge, Ellen Margrethe

PY - 2020

Y1 - 2020

N2 - Purpose: To investigate the positive predictive value (PPV) of the giant cell arteritis (GCA) diagnosis in the Danish National Patient Registry (DNPR). Patients and Methods: A total of 293 patients aged ≥50 years with a first-time diagnosis of GCA in the DNPR between January 2012 and December 2017 were included. Patients were sampled from two secondary and one tertiary care hospitals in the Central Region Denmark. Two independent investigators (PH & PT) reviewed all medical files, including medical records, treatment, biochemistry, histopathology and imaging, and either confirmed or dismissed the diagnosis of GCA. In case of disagreement, a consensus agreement was reached. Sub-analyses including number of redeemed prescriptions performed temporal artery biopsies (TABs), and number of GCA-related hospital contacts were performed. Results: We confirmed the diagnosis of GCA in 183/293 patients resulting in a PPV of 62% (95% CI: 57–68). In patients with ≥3 redeemed prescriptions of glucocorticoids (GCs), we confirmed the diagnosis in 166/214 resulting in a PPV of 78% (95% CI: 71–83). In patients with ≥3 redeemed prescriptions of GCs and ≥3 GCA-related hospital contacts, we confirmed the diagnosis in 88/95 resulting in a PPV of 93% (95% CI: 85–96); however, this only included 88/183 confirmed GCA patients. Conclusion: This is the first study to validate the diagnostic code of GCA in the DNPR. The overall PPVof GCA in the DNPR was 62%. Requiring redeemed prescriptions of GCs and/or GCA-related hospital contacts increase the PPV, but also excludes a significant number of GCA patients.

AB - Purpose: To investigate the positive predictive value (PPV) of the giant cell arteritis (GCA) diagnosis in the Danish National Patient Registry (DNPR). Patients and Methods: A total of 293 patients aged ≥50 years with a first-time diagnosis of GCA in the DNPR between January 2012 and December 2017 were included. Patients were sampled from two secondary and one tertiary care hospitals in the Central Region Denmark. Two independent investigators (PH & PT) reviewed all medical files, including medical records, treatment, biochemistry, histopathology and imaging, and either confirmed or dismissed the diagnosis of GCA. In case of disagreement, a consensus agreement was reached. Sub-analyses including number of redeemed prescriptions performed temporal artery biopsies (TABs), and number of GCA-related hospital contacts were performed. Results: We confirmed the diagnosis of GCA in 183/293 patients resulting in a PPV of 62% (95% CI: 57–68). In patients with ≥3 redeemed prescriptions of glucocorticoids (GCs), we confirmed the diagnosis in 166/214 resulting in a PPV of 78% (95% CI: 71–83). In patients with ≥3 redeemed prescriptions of GCs and ≥3 GCA-related hospital contacts, we confirmed the diagnosis in 88/95 resulting in a PPV of 93% (95% CI: 85–96); however, this only included 88/183 confirmed GCA patients. Conclusion: This is the first study to validate the diagnostic code of GCA in the DNPR. The overall PPVof GCA in the DNPR was 62%. Requiring redeemed prescriptions of GCs and/or GCA-related hospital contacts increase the PPV, but also excludes a significant number of GCA patients.

KW - Danish National Patient Registry

KW - Giant cell arteritis

KW - Positive predictive value

KW - Rheumatology

KW - Validation

UR - http://www.scopus.com/inward/record.url?scp=85087821681&partnerID=8YFLogxK

U2 - 10.2147/CLEP.S258219

DO - 10.2147/CLEP.S258219

M3 - Journal article

AN - SCOPUS:85087821681

VL - 12

SP - 731

EP - 736

JO - Clinical Epidemiology

JF - Clinical Epidemiology

SN - 1179-1349

ER -