Positive predictive value of the giant cell arteritis diagnosis in the danish national patient registry: A validation study

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DOI

Purpose: To investigate the positive predictive value (PPV) of the giant cell arteritis (GCA) diagnosis in the Danish National Patient Registry (DNPR). Patients and Methods: A total of 293 patients aged ≥50 years with a first-time diagnosis of GCA in the DNPR between January 2012 and December 2017 were included. Patients were sampled from two secondary and one tertiary care hospitals in the Central Region Denmark. Two independent investigators (PH & PT) reviewed all medical files, including medical records, treatment, biochemistry, histopathology and imaging, and either confirmed or dismissed the diagnosis of GCA. In case of disagreement, a consensus agreement was reached. Sub-analyses including number of redeemed prescriptions performed temporal artery biopsies (TABs), and number of GCA-related hospital contacts were performed. Results: We confirmed the diagnosis of GCA in 183/293 patients resulting in a PPV of 62% (95% CI: 57–68). In patients with ≥3 redeemed prescriptions of glucocorticoids (GCs), we confirmed the diagnosis in 166/214 resulting in a PPV of 78% (95% CI: 71–83). In patients with ≥3 redeemed prescriptions of GCs and ≥3 GCA-related hospital contacts, we confirmed the diagnosis in 88/95 resulting in a PPV of 93% (95% CI: 85–96); however, this only included 88/183 confirmed GCA patients. Conclusion: This is the first study to validate the diagnostic code of GCA in the DNPR. The overall PPVof GCA in the DNPR was 62%. Requiring redeemed prescriptions of GCs and/or GCA-related hospital contacts increase the PPV, but also excludes a significant number of GCA patients.

Original languageEnglish
JournalClinical epidemiology
Volume12
Pages (from-to)731-736
Number of pages6
ISSN1179-1349
DOIs
Publication statusPublished - 2020

    Research areas

  • Danish National Patient Registry, Giant cell arteritis, Positive predictive value, Rheumatology, Validation

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