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Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Kumar Gaurav, Norwich Research Park
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  • Sanu Arora, Norwich Research Park
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  • Paula Silva, Kansas State University, National Institute for Agricultural Research
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  • Javier Sánchez-Martín, University of Zurich
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  • Richard Horsnell, National Institute of Agricultural Botany
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  • Liangliang Gao, Kansas State University
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  • Gurcharn S. Brar, University of Saskatchewan, University of British Columbia
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  • Victoria Widrig, University of Zurich
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  • W. John Raupp, Kansas State University
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  • Narinder Singh, Kansas State University, Bayer R&D Services LLC
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  • Shuangye Wu, Kansas State University
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  • Sandip M. Kale, Leibniz Institute of Plant Genetics and Crop Plant Research
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  • Catherine Chinoy, Norwich Research Park
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  • Paul Nicholson, Norwich Research Park
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  • Jesús Quiroz-Chávez, Norwich Research Park
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  • James Simmonds, Norwich Research Park
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  • Sadiye Hayta, Norwich Research Park
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  • Mark A. Smedley, Norwich Research Park
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  • Wendy Harwood, Norwich Research Park
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  • Suzannah Pearce, Norwich Research Park
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  • David Gilbert, Norwich Research Park
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  • Ngonidzashe Kangara, Norwich Research Park
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  • Catherine Gardener, Norwich Research Park
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  • Macarena Forner-Martínez, Norwich Research Park
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  • Jiaqian Liu, Norwich Research Park, Nanjing Agricultural University
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  • Guotai Yu, Norwich Research Park
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  • Scott A. Boden, Norwich Research Park, University of Adelaide
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  • Attilio Pascucci, Norwich Research Park, University of Bologna
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  • Sreya Ghosh, Norwich Research Park
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  • Amber N. Hafeez, Norwich Research Park
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  • Tom O’Hara, Norwich Research Park
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  • Joshua Waites, Norwich Research Park
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  • Jitender Cheema, Norwich Research Park
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  • Burkhard Steuernagel, Norwich Research Park
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  • Mehran Patpour
  • Annemarie Fejer Justesen
  • Shuyu Liu, Texas A and M University
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  • Jackie C. Rudd, Texas A and M University
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  • Raz Avni, Tel Aviv University
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  • Amir Sharon, Tel Aviv University
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  • Barbara Steiner, University of Natural Resources and Life Sciences, Vienna
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  • Rizky Pasthika Kirana, University of Natural Resources and Life Sciences, Vienna, Gadjah Mada University
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  • Hermann Buerstmayr, University of Natural Resources and Life Sciences, Vienna
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  • Ali A. Mehrabi, Ilam University
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  • Firuza Y. Nasyrova, Academy of Sciences of the Republic of Tadzhikistan
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  • Noam Chayut, Norwich Research Park
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  • Oadi Matny, University of Minnesota
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  • Brian J. Steffenson, University of Minnesota
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  • Nitika Sandhu, Punjab Agricultural University
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  • Parveen Chhuneja, Punjab Agricultural University
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  • Evans Lagudah, CSIRO
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  • Ahmed F. Elkot, Agricultural Research Center
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  • Simon Tyrrell, Norwich Research Park
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  • Xingdong Bian, Norwich Research Park
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  • Robert P. Davey, Norwich Research Park
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  • Martin Simonsen, QIAGEN Aarhus A/S
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  • Leif Schauser, QIAGEN Aarhus A/S
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  • Vijay K. Tiwari, University of Maryland, College Park
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  • H. Randy Kutcher, University of Saskatchewan
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  • Pierre Hucl, University of Saskatchewan
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  • Aili Li, Chinese Academy of Agricultural Sciences
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  • Deng Cai Liu, Sichuan Agricultural University
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  • Long Mao, Chinese Academy of Agricultural Sciences
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  • Steven Xu, United States Department of Agriculture
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  • Gina Brown-Guedira, North Carolina State University
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  • Justin Faris, United States Department of Agriculture
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  • Jan Dvorak, University of California at Davis
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  • Ming Cheng Luo, University of California at Davis
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  • Ksenia Krasileva, University of California
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  • Thomas Lux, Helmholtz Zentrum München - German Research Center for Environmental Health
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  • Susanne Artmeier, Helmholtz Zentrum München - German Research Center for Environmental Health
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  • Klaus F.X. Mayer, Helmholtz Zentrum München - German Research Center for Environmental Health, Technical University Munich
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  • Cristobal Uauy, Norwich Research Park
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  • Martin Mascher, Leibniz Institute of Plant Genetics and Crop Plant Research, German Centre for Integrative Biodiversity Research Halle-Jena-Leipzig
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  • Alison R. Bentley, National Institute of Agricultural Botany
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  • Beat Keller, University of Zurich
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  • Jesse Poland, Kansas State University
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  • Brande B.H. Wulff, Norwich Research Park

Aegilops tauschii, the diploid wild progenitor of the D subgenome of bread wheat, is a reservoir of genetic diversity for improving bread wheat performance and environmental resilience. Here we sequenced 242 Ae. tauschii accessions and compared them to the wheat D subgenome to characterize genomic diversity. We found that a rare lineage of Ae. tauschii geographically restricted to present-day Georgia contributed to the wheat D subgenome in the independent hybridizations that gave rise to modern bread wheat. Through k-mer-based association mapping, we identified discrete genomic regions with candidate genes for disease and pest resistance and demonstrated their functional transfer into wheat by transgenesis and wide crossing, including the generation of a library of hexaploids incorporating diverse Ae. tauschii genomes. Exploiting the genomic diversity of the Ae. tauschii ancestral diploid genome permits rapid trait discovery and functional genetic validation in a hexaploid background amenable to breeding.

Original languageEnglish
JournalNature Biotechnology
Volume40
Issue3
Pages (from-to)422-431
Number of pages10
ISSN1087-0156
DOIs
Publication statusPublished - Mar 2022

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