Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Catherine M Phelan
  • ,
  • Ya-Yu Tsai
  • ,
  • Ellen L Goode
  • ,
  • Robert A Vierkant
  • ,
  • Brooke L Fridley
  • ,
  • Jonathan Beesley
  • ,
  • Xiao Qing Chen, Denmark
  • Penelope M Webb
  • ,
  • Stephen Chanock
  • ,
  • Kirsten Moysich
  • ,
  • Robert Edwards
  • ,
  • Jenny Chang-Claude
  • ,
  • Montserrat Garcia-Closas
  • ,
  • Hannah Yang
  • ,
  • Shan Wang-Gohrke
  • ,
  • Rebecca Hein
  • ,
  • Adele C Green
  • Jolanta Lissowska
  • ,
  • Michael E Carney
  • ,
  • Galina Lurie
  • ,
  • Lynne R Wilkens
  • ,
  • Roberta B Ness
  • ,
  • Celeste Leigh Pearce, Denmark
  • Anna H Wu
  • ,
  • David J Van Den Berg
  • ,
  • Daniel O Stram
  • ,
  • Kathryn L Terry
  • ,
  • David C Whiteman
  • ,
  • Alice S Whittemore
  • ,
  • Richard A DiCioccio
  • ,
  • Valerie McGuire
  • ,
  • Jennifer A Doherty
  • ,
  • Mary Anne Rossing, Denmark
  • Hoda Anton-Culver
  • ,
  • Argyrios Ziogas
  • ,
  • Claus Hogdall
  • ,
  • Estrid Hogdall
  • ,
  • Susanne Krüger Kjaer
  • ,
  • Jan Blaakaer, Denmark
  • Lydia Quaye
  • ,
  • Susan J Ramus
  • ,
  • Ian Jacobs
  • ,
  • Honglin Song
  • ,
  • Paul D P Pharoah
  • ,
  • Edwin S Iversen, Denmark
  • Jeffrey R Marks
  • ,
  • Malcolm C Pike
  • ,
  • Simon A Gayther
  • ,
  • Julie M Cunningham
  • ,
  • Marc T Goodman
  • ,
  • Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer)
  • The Department of Endocrinology and Metabolism C
  • Obstetrics and Gynaecology
Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for heterogeneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.
Original languageEnglish
JournalCancer Epidemiology, Biomarkers & Prevention
Volume19
Issue2
Pages (from-to)600-4
Number of pages5
ISSN1055-9965
DOIs
Publication statusPublished - 1 Feb 2010

    Research areas

  • Case-Control Studies, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Humans, Middle Aged, N-Acetylgalactosaminyltransferases, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Polymorphism, Single Nucleotide

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