Polymers Fight HIV: Potent (Pro)Drugs Identified Through Parallel Automated Synthesis

Kaja Zuwala; Anton A A Smith; Almar Postma; Carlos Guerrero-Sanchez; Pau Ruiz Sanchis; Jesper Melchjorsen; Martin Tolstrup; Alexander N. Zelikin

doi:10.1002/adhm.201400148

Polymers Fight HIV: Potent (Pro)Drugs Identified Through Parallel Automated Synthesis

Kaja Zuwala, Anton A A Smith, Almar Postma, Carlos Guerrero-Sanchez, Pau Ruiz Sanchis, Jesper Melchjorsen, Martin Tolstrup, Alexander N. Zelikin

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

15 Citations (Scopus)

Abstract

Macromolecular (pro)drugs interfere with the proliferation of HIV through both inhibition of viral cell entry and via intracellular delivery of antiviral drugs. Lead polymer conjugates exhibit longevity of action exceeding that of parent nucleoside analogue drug and are active in primary T cell over at least 72 h.

Original language	English
Journal	Advanced Healthcare Materials
Volume	4
Issue	1
Pages (from-to)	46-50
Number of pages	5
ISSN	2192-2640
DOIs	https://doi.org/10.1002/adhm.201400148
Publication status	Published - 2015

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10.1002/adhm.201400148

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title = "Polymers Fight HIV: Potent (Pro)Drugs Identified Through Parallel Automated Synthesis",

abstract = "Macromolecular (pro)drugs interfere with the proliferation of HIV through both inhibition of viral cell entry and via intracellular delivery of antiviral drugs. Lead polymer conjugates exhibit longevity of action exceeding that of parent nucleoside analogue drug and are active in primary T cell over at least 72 h.",

author = "Kaja Zuwala and Smith, {Anton A A} and Almar Postma and Carlos Guerrero-Sanchez and {Ruiz Sanchis}, Pau and Jesper Melchjorsen and Martin Tolstrup and Zelikin, {Alexander N.}",

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AU - Zuwala, Kaja

AU - Smith, Anton A A

AU - Postma, Almar

AU - Guerrero-Sanchez, Carlos

AU - Ruiz Sanchis, Pau

AU - Melchjorsen, Jesper

AU - Tolstrup, Martin

AU - Zelikin, Alexander N.

PY - 2015

Y1 - 2015

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DO - 10.1002/adhm.201400148

M3 - Journal article

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JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

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Polymers Fight HIV: Potent (Pro)Drugs Identified Through Parallel Automated Synthesis

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