Pluronic F127-folate coated super paramagenic iron oxide nanoparticles as contrast agent for cancer diagnosis in magnetic resonance imaging

Hieu Vu-Quang; Mads Sloth Vinding; Thomas Nielsen; Marcus Görge Ullisch; Niels Chr Nielsen; Dinh Truong Nguyen; Jørgen Kjems

doi:10.3390/polym11040743

Pluronic F127-folate coated super paramagenic iron oxide nanoparticles as contrast agent for cancer diagnosis in magnetic resonance imaging

Hieu Vu-Quang^*, Mads Sloth Vinding, Thomas Nielsen, Marcus Görge Ullisch, Niels Chr Nielsen, Dinh Truong Nguyen, Jørgen Kjems

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Contrast agents have been widely used in medicine to enhance contrast in magnetic resonance imaging (MRI). Among them, super paramagnetic iron oxide nanoparticles (SPION) have been reported to have low risk in clinical use. In our study, F127-Folate coated SPION was fabricated in order to efficiently target tumors and provide imaging contrast in MRI. SPION alone have an average core size of 15 nm. After stabilizing with Pluronic F127, the nanoparticles reached a hydrodynamic size of 180 nm and dispersed well in various kinds of media. The F127-Folate coated SPION were shown to specifically target folate receptor expressing cancer cells by flow cytometry analysis, confocal laser scanning microscope, as well as in vitro MRI. Furthermore, in vivo MRI images have shown the enhanced negative contrast from the F127-Folate coated SPION in tumor-bearing mice. In conclusion, our F127-Folate coated SPION have shown great potential as a contrast agent in MRI, as well as in the combination with drug delivery for cancer therapy.

Original language	English
Article number	743
Journal	Polymers
Volume	11
Issue	4
ISSN	2073-4360
DOIs	https://doi.org/10.3390/polym11040743
Publication status	Published - Apr 2019

Keywords

Cancer diagnosis
Contrast agent
Folate receptor
MRI
Pluronic F127
SPION

Access to Document

10.3390/polym11040743

Cite this

@article{3805ba3deac24253836b4b5bab12fa31,

title = "Pluronic F127-folate coated super paramagenic iron oxide nanoparticles as contrast agent for cancer diagnosis in magnetic resonance imaging",

abstract = "Contrast agents have been widely used in medicine to enhance contrast in magnetic resonance imaging (MRI). Among them, super paramagnetic iron oxide nanoparticles (SPION) have been reported to have low risk in clinical use. In our study, F127-Folate coated SPION was fabricated in order to efficiently target tumors and provide imaging contrast in MRI. SPION alone have an average core size of 15 nm. After stabilizing with Pluronic F127, the nanoparticles reached a hydrodynamic size of 180 nm and dispersed well in various kinds of media. The F127-Folate coated SPION were shown to specifically target folate receptor expressing cancer cells by flow cytometry analysis, confocal laser scanning microscope, as well as in vitro MRI. Furthermore, in vivo MRI images have shown the enhanced negative contrast from the F127-Folate coated SPION in tumor-bearing mice. In conclusion, our F127-Folate coated SPION have shown great potential as a contrast agent in MRI, as well as in the combination with drug delivery for cancer therapy.",

keywords = "Cancer diagnosis, Contrast agent, Folate receptor, MRI, Pluronic F127, SPION",

author = "Hieu Vu-Quang and Vinding, {Mads Sloth} and Thomas Nielsen and Ullisch, {Marcus G{\"o}rge} and Nielsen, {Niels Chr} and Nguyen, {Dinh Truong} and J{\o}rgen Kjems",

year = "2019",

month = apr,

doi = "10.3390/polym11040743",

language = "English",

volume = "11",

journal = "Polymers",

issn = "2073-4360",

publisher = "M D P I AG",

number = "4",

}

Pluronic F127-folate coated super paramagenic iron oxide nanoparticles as contrast agent for cancer diagnosis in magnetic resonance imaging. / Vu-Quang, Hieu; Vinding, Mads Sloth ; Nielsen, Thomas et al.
In: Polymers, Vol. 11, No. 4, 743, 04.2019.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Pluronic F127-folate coated super paramagenic iron oxide nanoparticles as contrast agent for cancer diagnosis in magnetic resonance imaging

AU - Vu-Quang, Hieu

AU - Vinding, Mads Sloth

AU - Nielsen, Thomas

AU - Ullisch, Marcus Görge

AU - Nielsen, Niels Chr

AU - Nguyen, Dinh Truong

AU - Kjems, Jørgen

PY - 2019/4

Y1 - 2019/4

N2 - Contrast agents have been widely used in medicine to enhance contrast in magnetic resonance imaging (MRI). Among them, super paramagnetic iron oxide nanoparticles (SPION) have been reported to have low risk in clinical use. In our study, F127-Folate coated SPION was fabricated in order to efficiently target tumors and provide imaging contrast in MRI. SPION alone have an average core size of 15 nm. After stabilizing with Pluronic F127, the nanoparticles reached a hydrodynamic size of 180 nm and dispersed well in various kinds of media. The F127-Folate coated SPION were shown to specifically target folate receptor expressing cancer cells by flow cytometry analysis, confocal laser scanning microscope, as well as in vitro MRI. Furthermore, in vivo MRI images have shown the enhanced negative contrast from the F127-Folate coated SPION in tumor-bearing mice. In conclusion, our F127-Folate coated SPION have shown great potential as a contrast agent in MRI, as well as in the combination with drug delivery for cancer therapy.

AB - Contrast agents have been widely used in medicine to enhance contrast in magnetic resonance imaging (MRI). Among them, super paramagnetic iron oxide nanoparticles (SPION) have been reported to have low risk in clinical use. In our study, F127-Folate coated SPION was fabricated in order to efficiently target tumors and provide imaging contrast in MRI. SPION alone have an average core size of 15 nm. After stabilizing with Pluronic F127, the nanoparticles reached a hydrodynamic size of 180 nm and dispersed well in various kinds of media. The F127-Folate coated SPION were shown to specifically target folate receptor expressing cancer cells by flow cytometry analysis, confocal laser scanning microscope, as well as in vitro MRI. Furthermore, in vivo MRI images have shown the enhanced negative contrast from the F127-Folate coated SPION in tumor-bearing mice. In conclusion, our F127-Folate coated SPION have shown great potential as a contrast agent in MRI, as well as in the combination with drug delivery for cancer therapy.

KW - Cancer diagnosis

KW - Contrast agent

KW - Folate receptor

KW - MRI

KW - Pluronic F127

KW - SPION

UR - http://www.scopus.com/inward/record.url?scp=85065911333&partnerID=8YFLogxK

U2 - 10.3390/polym11040743

DO - 10.3390/polym11040743

M3 - Journal article

C2 - 31027171

AN - SCOPUS:85065911333

SN - 2073-4360

VL - 11

JO - Polymers

JF - Polymers

IS - 4

M1 - 743

ER -

Pluronic F127-folate coated super paramagenic iron oxide nanoparticles as contrast agent for cancer diagnosis in magnetic resonance imaging

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this