Platformsforsøg

Anders Perner; Maj Brit N. Kjær; Hans Christian Thorsen-Meyer; Benjamin S. Kaas-Hansen; Marie W. Munch; Marie O. Collet; Camilla Rl Bruun; Aksel Kg Jensen; Theis Lange; Trine Albertsen; Claus Duedal Pedersen; Lone M. Poulsen; Ole Mathiesen; Anne C. Brøchner; Thomas Strøm; Lars W. Andersen; Steffen Christensen; Bodil S. Rasmussen; Olav L. Schjørring; Mathias Maagaard; Morten Hylander Møller; Anders Granholm

Platformsforsøg

Translated title of the contribution: Platform trials

Anders Perner, Maj Brit N. Kjær, Hans Christian Thorsen-Meyer, Benjamin S. Kaas-Hansen, Marie W. Munch, Marie O. Collet, Camilla Rl Bruun, Aksel Kg Jensen, Theis Lange, Trine Albertsen, Claus Duedal Pedersen, Lone M. Poulsen, Ole Mathiesen, Anne C. Brøchner, Thomas Strøm, Lars W. Andersen, Steffen Christensen, Bodil S. Rasmussen, Olav L. Schjørring, Mathias MaagaardMorten Hylander Møller, Anders Granholm

Department of Clinical Medicine - Anaesthesiology and Operation, Intensive care

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Abstract

Platform trials focus on the perpetual testing of many interventions in a disease or a setting. These trials have lasting organizational, administrative, data, analytic, and operational frameworks making them highly efficient. The use of adaptation often increases the probabilities of allocating participants to better interventions and obtaining conclusive results. The COVID-19 pandemic showed the potential of platform trials as a fast and valid way to improved treatments. This review gives an overview of key concepts and elements using the Intensive Care Platform Trial (INCEPT) as an example.

Translated title of the contribution	Platform trials
Original language	Danish
Article number	V04230237
Journal	Ugeskrift for Læger
Volume	185
Issue	41
Number of pages	10
ISSN	0041-5782
Publication status	Published - 9 Oct 2023

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Perner, A., Kjær, M. B. N., Thorsen-Meyer, H. C., Kaas-Hansen, B. S., Munch, M. W., Collet, M. O., Bruun, C. R., Jensen, A. K., Lange, T., Albertsen, T., Pedersen, C. D., Poulsen, L. M., Mathiesen, O., Brøchner, A. C., Strøm, T., Andersen, L. W., Christensen, S., Rasmussen, B. S., Schjørring, O. L., ... Granholm, A. (2023). Platformsforsøg. Ugeskrift for Læger, 185(41), Article V04230237.

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abstract = "Platform trials focus on the perpetual testing of many interventions in a disease or a setting. These trials have lasting organizational, administrative, data, analytic, and operational frameworks making them highly efficient. The use of adaptation often increases the probabilities of allocating participants to better interventions and obtaining conclusive results. The COVID-19 pandemic showed the potential of platform trials as a fast and valid way to improved treatments. This review gives an overview of key concepts and elements using the Intensive Care Platform Trial (INCEPT) as an example.",

keywords = "Humans, Pandemics, COVID-19/epidemiology, Adaptive Clinical Trials as Topic",

author = "Anders Perner and Kj{\ae}r, {Maj Brit N.} and Thorsen-Meyer, {Hans Christian} and Kaas-Hansen, {Benjamin S.} and Munch, {Marie W.} and Collet, {Marie O.} and Bruun, {Camilla Rl} and Jensen, {Aksel Kg} and Theis Lange and Trine Albertsen and Pedersen, {Claus Duedal} and Poulsen, {Lone M.} and Ole Mathiesen and Br{\o}chner, {Anne C.} and Thomas Str{\o}m and Andersen, {Lars W.} and Steffen Christensen and Rasmussen, {Bodil S.} and Schj{\o}rring, {Olav L.} and Mathias Maagaard and M{\o}ller, {Morten Hylander} and Anders Granholm",

note = "Publisher Copyright: Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.",

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Perner, A, Kjær, MBN, Thorsen-Meyer, HC, Kaas-Hansen, BS, Munch, MW, Collet, MO, Bruun, CR, Jensen, AK, Lange, T, Albertsen, T, Pedersen, CD, Poulsen, LM, Mathiesen, O, Brøchner, AC, Strøm, T, Andersen, LW , Christensen, S, Rasmussen, BS, Schjørring, OL, Maagaard, M, Møller, MH & Granholm, A 2023, 'Platformsforsøg', Ugeskrift for Læger, vol. 185, no. 41, V04230237.

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T1 - Platformsforsøg

AU - Perner, Anders

AU - Kjær, Maj Brit N.

AU - Thorsen-Meyer, Hans Christian

AU - Kaas-Hansen, Benjamin S.

AU - Munch, Marie W.

AU - Collet, Marie O.

AU - Bruun, Camilla Rl

AU - Jensen, Aksel Kg

AU - Lange, Theis

AU - Albertsen, Trine

AU - Pedersen, Claus Duedal

AU - Poulsen, Lone M.

AU - Mathiesen, Ole

AU - Brøchner, Anne C.

AU - Strøm, Thomas

AU - Andersen, Lars W.

AU - Christensen, Steffen

AU - Rasmussen, Bodil S.

AU - Schjørring, Olav L.

AU - Maagaard, Mathias

AU - Møller, Morten Hylander

AU - Granholm, Anders

N1 - Publisher Copyright: Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

PY - 2023/10/9

Y1 - 2023/10/9

N2 - Platform trials focus on the perpetual testing of many interventions in a disease or a setting. These trials have lasting organizational, administrative, data, analytic, and operational frameworks making them highly efficient. The use of adaptation often increases the probabilities of allocating participants to better interventions and obtaining conclusive results. The COVID-19 pandemic showed the potential of platform trials as a fast and valid way to improved treatments. This review gives an overview of key concepts and elements using the Intensive Care Platform Trial (INCEPT) as an example.

AB - Platform trials focus on the perpetual testing of many interventions in a disease or a setting. These trials have lasting organizational, administrative, data, analytic, and operational frameworks making them highly efficient. The use of adaptation often increases the probabilities of allocating participants to better interventions and obtaining conclusive results. The COVID-19 pandemic showed the potential of platform trials as a fast and valid way to improved treatments. This review gives an overview of key concepts and elements using the Intensive Care Platform Trial (INCEPT) as an example.

KW - Humans

KW - Pandemics

KW - COVID-19/epidemiology

KW - Adaptive Clinical Trials as Topic

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JO - Ugeskrift for Læger

JF - Ugeskrift for Læger

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M1 - V04230237

ER -

Platformsforsøg

Abstract

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