Platelet 3H‐imipramine binding and sulphotransferase activity in primary headache

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Platelet 3H‐imipramine binding and sulphotransferase activity in primary headache. / Marazziti, D.; Bonuccelli, U.; Nuti, A.; Toni, C.; Pedri, S.; Palego, L.; Pavese, N.; Lucetti, C.; Muratorio, A.; Cassano, GB.

In: Cephalalgia, Vol. 14, No. 3, 01.01.1994, p. 210-214.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Marazziti, D, Bonuccelli, U, Nuti, A, Toni, C, Pedri, S, Palego, L, Pavese, N, Lucetti, C, Muratorio, A & Cassano, GB 1994, 'Platelet 3H‐imipramine binding and sulphotransferase activity in primary headache', Cephalalgia, vol. 14, no. 3, pp. 210-214. https://doi.org/10.1046/j.1468-2982.1994.014003210.x

APA

Marazziti, D., Bonuccelli, U., Nuti, A., Toni, C., Pedri, S., Palego, L., Pavese, N., Lucetti, C., Muratorio, A., & Cassano, GB. (1994). Platelet 3H‐imipramine binding and sulphotransferase activity in primary headache. Cephalalgia, 14(3), 210-214. https://doi.org/10.1046/j.1468-2982.1994.014003210.x

CBE

Marazziti D, Bonuccelli U, Nuti A, Toni C, Pedri S, Palego L, Pavese N, Lucetti C, Muratorio A, Cassano GB. 1994. Platelet 3H‐imipramine binding and sulphotransferase activity in primary headache. Cephalalgia. 14(3):210-214. https://doi.org/10.1046/j.1468-2982.1994.014003210.x

MLA

Vancouver

Marazziti D, Bonuccelli U, Nuti A, Toni C, Pedri S, Palego L et al. Platelet 3H‐imipramine binding and sulphotransferase activity in primary headache. Cephalalgia. 1994 Jan 1;14(3):210-214. https://doi.org/10.1046/j.1468-2982.1994.014003210.x

Author

Marazziti, D. ; Bonuccelli, U. ; Nuti, A. ; Toni, C. ; Pedri, S. ; Palego, L. ; Pavese, N. ; Lucetti, C. ; Muratorio, A. ; Cassano, GB. / Platelet 3H‐imipramine binding and sulphotransferase activity in primary headache. In: Cephalalgia. 1994 ; Vol. 14, No. 3. pp. 210-214.

Bibtex

@article{60775bcc09d643e2be09bc82cf2392ee,
title = "Platelet 3H‐imipramine binding and sulphotransferase activity in primary headache",
abstract = "We investigated platelet 3H‐imipramine (3H‐IMI) binding, a putative peripheral serotonergic marker, and the activity of sulphotransferase (ST), an enzyme involved in the catabolism of catecholamines and phenolic compounds, in 14 patients suffering from migraine without aura (MWoA) and in 10 with tension‐type headache (TH), as compared with a group of controls. The possible relationships between the biological parameters and clinical features were also examined. The results showed that the two groups of patients had a lower number of 3H‐IMI binding sites and a lower activity of the thermolabile form of ST, which acts preferentially on monoamine substrates, than the healthy controls, with no intergroup differences. Significant correlations between psychopathological rating scales and characteristics of the illness were observed in the patients with TH. The decreased number of platelet 3H‐IMI binding sites is suggestive of a presynaptic serotonergic dysfunction and confirms the involvement of 5HT in primary headaches. The reduced ST activity might produce changes in the level of sulphated biogenic amines, including dopamine and tyramine, which might have an additional role in the pathophysiology of some aspects of primary headache.",
keywords = "H‐imipramine binding, Migraine, platelets, tension‐type headache",
author = "D. Marazziti and U. Bonuccelli and A. Nuti and C. Toni and S. Pedri and L. Palego and N. Pavese and C. Lucetti and A. Muratorio and GB Cassano",
year = "1994",
month = jan,
day = "1",
doi = "10.1046/j.1468-2982.1994.014003210.x",
language = "English",
volume = "14",
pages = "210--214",
journal = "Cephalalgia : an international journal of headache",
issn = "0333-1024",
number = "3",

}

RIS

TY - JOUR

T1 - Platelet 3H‐imipramine binding and sulphotransferase activity in primary headache

AU - Marazziti, D.

AU - Bonuccelli, U.

AU - Nuti, A.

AU - Toni, C.

AU - Pedri, S.

AU - Palego, L.

AU - Pavese, N.

AU - Lucetti, C.

AU - Muratorio, A.

AU - Cassano, GB

PY - 1994/1/1

Y1 - 1994/1/1

N2 - We investigated platelet 3H‐imipramine (3H‐IMI) binding, a putative peripheral serotonergic marker, and the activity of sulphotransferase (ST), an enzyme involved in the catabolism of catecholamines and phenolic compounds, in 14 patients suffering from migraine without aura (MWoA) and in 10 with tension‐type headache (TH), as compared with a group of controls. The possible relationships between the biological parameters and clinical features were also examined. The results showed that the two groups of patients had a lower number of 3H‐IMI binding sites and a lower activity of the thermolabile form of ST, which acts preferentially on monoamine substrates, than the healthy controls, with no intergroup differences. Significant correlations between psychopathological rating scales and characteristics of the illness were observed in the patients with TH. The decreased number of platelet 3H‐IMI binding sites is suggestive of a presynaptic serotonergic dysfunction and confirms the involvement of 5HT in primary headaches. The reduced ST activity might produce changes in the level of sulphated biogenic amines, including dopamine and tyramine, which might have an additional role in the pathophysiology of some aspects of primary headache.

AB - We investigated platelet 3H‐imipramine (3H‐IMI) binding, a putative peripheral serotonergic marker, and the activity of sulphotransferase (ST), an enzyme involved in the catabolism of catecholamines and phenolic compounds, in 14 patients suffering from migraine without aura (MWoA) and in 10 with tension‐type headache (TH), as compared with a group of controls. The possible relationships between the biological parameters and clinical features were also examined. The results showed that the two groups of patients had a lower number of 3H‐IMI binding sites and a lower activity of the thermolabile form of ST, which acts preferentially on monoamine substrates, than the healthy controls, with no intergroup differences. Significant correlations between psychopathological rating scales and characteristics of the illness were observed in the patients with TH. The decreased number of platelet 3H‐IMI binding sites is suggestive of a presynaptic serotonergic dysfunction and confirms the involvement of 5HT in primary headaches. The reduced ST activity might produce changes in the level of sulphated biogenic amines, including dopamine and tyramine, which might have an additional role in the pathophysiology of some aspects of primary headache.

KW - H‐imipramine binding

KW - Migraine

KW - platelets

KW - tension‐type headache

UR - http://www.scopus.com/inward/record.url?scp=0028183141&partnerID=8YFLogxK

U2 - 10.1046/j.1468-2982.1994.014003210.x

DO - 10.1046/j.1468-2982.1994.014003210.x

M3 - Journal article

C2 - 7954741

AN - SCOPUS:0028183141

VL - 14

SP - 210

EP - 214

JO - Cephalalgia : an international journal of headache

JF - Cephalalgia : an international journal of headache

SN - 0333-1024

IS - 3

ER -