Placental vascular responses are dependent on surrounding tissue: Moderkagens vaskulære regulering er afhængig af det omkringliggende væv

Research output: Contribution to conferencePosterResearchpeer-review

Abstract

Background.
The placenta is the base for the exchange of nutrients, oxygen and waste products for the fetus.The placental vessels hold a crucial role in regulation the blood flow, and a compromised placental function leads to serious complications such as fetal death or growth retardation.
Materials and methods.
From fresh born placentas, stem villi arteries were carefully dissected. The artery branches were divided. The surrounding tissue was removed from one end and was left untouched in the other end.Then, using wire myography, they were investigated in terms of contractility and sensitivity to physiological relevant human-like agonists.
Results.
Sensitivity to PGF2α, Tx-analog, 5-HT and endothelin-1 was significantly lower in arteries with intact surrounding tissue compared to arteries stripped of the tissue.
The maximal force development was also significantly lower in arteries with surrounding tissue when they were depolarized high extracellular [K+] or stimulated with PGF2α or endotheline-1.
Conclusion.
The perivascular tissue significantly alters stem villi arteries' sensitivity and force development in a suppressive way.
This implicates a new aspect of blood flow regulation in the placenta.


Original languageDanish
Publication date11 Jan 2013
Number of pages1
Publication statusPublished - 11 Jan 2013
EventAarhus University Graduate School of Health, PhD Day 2013: Future Talent - Future Challenge - Aarhus, Denmark
Duration: 11 Jan 201311 Jan 2013

Conference

ConferenceAarhus University Graduate School of Health, PhD Day 2013
Country/TerritoryDenmark
CityAarhus
Period11/01/201311/01/2013

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