Placental transfer of pesticides studied in human placental perfusion

Line Mathiesen; Thit Aarøe Mørck; Marie Sønnegaard Poulsen; Jeanette Kolstrup Søgaard Nielsen; Tina Mose; Manhai Long; Eva Bonefeld-Jørgensen; Rossana Bossi; Lisbeth E Knudsen

doi:10.1111/bcpt.13456

Placental transfer of pesticides studied in human placental perfusion

Line Mathiesen^*, Thit Aarøe Mørck, Marie Sønnegaard Poulsen, Jeanette Kolstrup Søgaard Nielsen, Tina Mose, Manhai Long, Eva Bonefeld-Jørgensen, Rossana Bossi, Lisbeth E Knudsen

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Abstract

To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin, and the fungicide azoles propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the selection criteria: use in Denmark, significant treated areas, and knowledge on hormone-disrupting effects. Propiconazole and bitertanol showed rapid transfer and adsorbance to the system in both placental perfusion and BeWo cell system, whereas cypermethrin had a slower transport across the placental cell layers in the two models. There was no difference between data of the single pesticides and their mixture in either placental perfusion or BeWo cell transfer model. Both the placental perfusion model and the BeWo cell model metabolized the pesticides and released metabolites into both foetal and maternal circulation. Using human exposure models, this study shows the potential exposure of the human foetus to pesticides cypermethrin, propiconazole and bitertanol and their metabolites.

Original language	English
Journal	Basic & Clinical Pharmacology & Toxicology
Volume	127
Issue	6
Pages (from-to)	505-515
Number of pages	11
ISSN	1742-7843
DOIs	https://doi.org/10.1111/bcpt.13456
Publication status	Published - Dec 2020

Keywords

BeWo cell model
bitertanol
cypermethrin
foetal exposure
pesticides
placental transport
propiconazole

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title = "Placental transfer of pesticides studied in human placental perfusion",

abstract = "To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin, and the fungicide azoles propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the selection criteria: use in Denmark, significant treated areas, and knowledge on hormone-disrupting effects. Propiconazole and bitertanol showed rapid transfer and adsorbance to the system in both placental perfusion and BeWo cell system, whereas cypermethrin had a slower transport across the placental cell layers in the two models. There was no difference between data of the single pesticides and their mixture in either placental perfusion or BeWo cell transfer model. Both the placental perfusion model and the BeWo cell model metabolized the pesticides and released metabolites into both foetal and maternal circulation. Using human exposure models, this study shows the potential exposure of the human foetus to pesticides cypermethrin, propiconazole and bitertanol and their metabolites.",

keywords = "BeWo cell model, bitertanol, cypermethrin, foetal exposure, pesticides, placental transport, propiconazole",

author = "Line Mathiesen and M{\o}rck, {Thit Aar{\o}e} and Poulsen, {Marie S{\o}nnegaard} and Nielsen, {Jeanette Kolstrup S{\o}gaard} and Tina Mose and Manhai Long and Eva Bonefeld-J{\o}rgensen and Rossana Bossi and Knudsen, {Lisbeth E}",

year = "2020",

month = dec,

doi = "10.1111/bcpt.13456",

language = "English",

volume = "127",

pages = "505--515",

journal = "Basic & Clinical Pharmacology & Toxicology",

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Placental transfer of pesticides studied in human placental perfusion. / Mathiesen, Line; Mørck, Thit Aarøe; Poulsen, Marie Sønnegaard et al.
In: Basic & Clinical Pharmacology & Toxicology, Vol. 127, No. 6, 12.2020, p. 505-515.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Placental transfer of pesticides studied in human placental perfusion

AU - Mathiesen, Line

AU - Mørck, Thit Aarøe

AU - Poulsen, Marie Sønnegaard

AU - Nielsen, Jeanette Kolstrup Søgaard

AU - Mose, Tina

AU - Long, Manhai

AU - Bonefeld-Jørgensen, Eva

AU - Bossi, Rossana

AU - Knudsen, Lisbeth E

PY - 2020/12

Y1 - 2020/12

N2 - To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin, and the fungicide azoles propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the selection criteria: use in Denmark, significant treated areas, and knowledge on hormone-disrupting effects. Propiconazole and bitertanol showed rapid transfer and adsorbance to the system in both placental perfusion and BeWo cell system, whereas cypermethrin had a slower transport across the placental cell layers in the two models. There was no difference between data of the single pesticides and their mixture in either placental perfusion or BeWo cell transfer model. Both the placental perfusion model and the BeWo cell model metabolized the pesticides and released metabolites into both foetal and maternal circulation. Using human exposure models, this study shows the potential exposure of the human foetus to pesticides cypermethrin, propiconazole and bitertanol and their metabolites.

AB - To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin, and the fungicide azoles propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the selection criteria: use in Denmark, significant treated areas, and knowledge on hormone-disrupting effects. Propiconazole and bitertanol showed rapid transfer and adsorbance to the system in both placental perfusion and BeWo cell system, whereas cypermethrin had a slower transport across the placental cell layers in the two models. There was no difference between data of the single pesticides and their mixture in either placental perfusion or BeWo cell transfer model. Both the placental perfusion model and the BeWo cell model metabolized the pesticides and released metabolites into both foetal and maternal circulation. Using human exposure models, this study shows the potential exposure of the human foetus to pesticides cypermethrin, propiconazole and bitertanol and their metabolites.

KW - BeWo cell model

KW - bitertanol

KW - cypermethrin

KW - foetal exposure

KW - pesticides

KW - placental transport

KW - propiconazole

U2 - 10.1111/bcpt.13456

DO - 10.1111/bcpt.13456

M3 - Journal article

C2 - 32558230

SN - 1742-7843

VL - 127

SP - 505

EP - 515

JO - Basic & Clinical Pharmacology & Toxicology

JF - Basic & Clinical Pharmacology & Toxicology

IS - 6

ER -

Placental transfer of pesticides studied in human placental perfusion

Abstract

Keywords

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