Photothermal conversion-coordinated Fenton-like and photocatalytic reactions of Cu2-xSe-Au Janus nanoparticles for tri-combination antitumor therapy

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  • Yuanlin Wang, Harbin Institute of Technology
  • ,
  • Zhenglin Li, School of Chemistry and Chemical Engineering, Harbin Institute of Technology
  • ,
  • Ying Hu, Harbin Institute of Technology
  • ,
  • Jing Liu, National Center for Nanoscience and Technology
  • ,
  • Mengyu Guo, National Center for Nanoscience and Technology
  • ,
  • Hengxiang Wei, Harbin Institute of Technology
  • ,
  • Shanliang Zheng, Harbin Institute of Technology
  • ,
  • Tingting Jiang, Harbin Institute of Technology
  • ,
  • Xiang Sun, Harbin Institute of Technology
  • ,
  • Zhuo Ma, Harbin Institute of Technology
  • ,
  • Ye Sun, Condensed Matter Science and Technology Institute and Department of Physics, Harbin Institute of Technology
  • ,
  • Flemming Besenbacher
  • Chunying Chen, National Center for Nanoscience and Technology
  • ,
  • Miao Yu, School of Chemistry and Chemical Engineering, Harbin Institute of Technology

In vivo chemical reactions activated by the tumor microenvironment (TME) are particularly promising for antitumor treatments. Herein, employing Cu2-xSe-Au Janus nanoparticles (NPs), photothermal conversion-coordinated Fenton-like and photocatalytic reactions are demonstrated in vitro/vivo. The amorphous form of Cu2-xSe and the catalytic effect of Au benefit the [rad]OH generation, and the photo-induced electron‒hole separation of the Janus NPs produces additional [rad]OH. The plasmonic electrons of Au facilitate the conversion from Cu2+ to Cu+. Both Cu2-xSe and Au contributes to the efficient photothermal conversion, further promoting the reactions. As a result, the H2O2 utilization rate is largely increased, and remarkable generation of reactive oxygen species is achieved by cell endogenous H2O2 in vitro/vivo. A competent tumor inhibition effect is afforded, with high-contrast multimodal imaging. This work opens up the route synergistically integrating photothermal therapy with chemodynamic therapy and photocatalytic therapy into tri-combination antitumor therapy, simply by heterojunction of semiconductor and noble metal.

Original languageEnglish
Article number120167
JournalBiomaterials
Volume255
ISSN0142-9612
DOIs
Publication statusPublished - Oct 2020

    Research areas

  • Chemodynamic therapy, In vivo chemical Reaction, Multimodal imaging, Photocatalytic therapy, Photothermal therapy

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