Pharmacokinetics of the phosphatidylserine tracers 99mTc-lactadherin and 99mTc-annexin V in pigs

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Abstract

Phosphatidylserine (PS) is a phospholipid normally located in the inner leaflet of the cell membrane. PS is translocated from the inner to the outer leaflet of the plasma membrane during the early stages of apoptosis and in necrosis. In cell and animal studies, reversible PS externalisation to the outer membrane leaflet has been observed in viable cells. Hence, PS markers have been proposed as markers of both reversibly and irreversibly damaged cells. The purpose of this experimental study in pigs was to investigate the kinetics of the newly introduced PS marker technetium-99m-labelled lactadherin (99mTc-lactadherin) in comparison with the well-known PS tracer 99mTc-annexin V with special reference to the renal handling of the tracers. The effective dose for humans was estimated from the biodistribution in 24 mice.

Original languageEnglish
JournalEJNMMI research
Volume3
Issue15
Number of pages9
ISSN2191-219X
DOIs
Publication statusPublished - 9 Mar 2013

Keywords

  • 99mTc-lactadherin
  • Lactadherin
  • 99mTc-annexin V
  • Annexin V
  • Kinetics
  • Distribution
  • Clearance
  • Phosphatidylserine
  • Dosimetry

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